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Genetics

D-Index
42
Citations
9463
World Ranking
4309
National Ranking
1861

Overview

Paula E. Cohen is affiliated with Cornell University in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with additional work in medicine. Their research primarily focuses on molecular biology, cancer research, reproductive medicine, radiology, nuclear medicine and imaging, and ophthalmology.

The topics covered by Cohen's work include:

  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Carcinogens and Genotoxicity Assessment
  • CRISPR and Genetic Engineering
  • Sperm and Testicular Function
  • Microtubule and Mitosis Dynamics

They have published frequently in a range of academic venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • eLife
  • Nature Communications
  • Nucleic Acids Research

Some of Cohen's recent publications include:

  • "A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis" (2023), Nature Communications
  • "Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial" (2021), Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring
  • "Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection" (2021), Nucleic Acids Research
  • "Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner" (2020), Cell Reports
  • "Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats" (2023), Nature Communications

Frequent collaborators include:

  • Marcus B. Smolka
  • Jennie R. Sims
  • Raimundo Freire
  • Robert S. Weiss
  • Stephen Gray

Best Publications

  • Meiotic Pachytene Arrest in MLH1-Deficient Mice

    Winfried Edelmann;Paula E Cohen;Michael Kane;Kirkland Lau

  • The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.

    Peter B. Moens;Nadine K. Kolas;Madalena Tarsounas;Edyta Marcon

  • MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice

    Burkhard Kneitz;Paula E. Cohen;Elena Avdievich;Liyin Zhu

  • Mammalian MutS homologue 5 is required for chromosome pairing in meiosis

    Winfried Edelmann;Paula E. Cohen;Burkhard Kneitz;Nena Winand

  • Meiotic arrest and aneuploidy in MLH3-deficient mice.

    Steven M Lipkin;Steven M Lipkin;Peter B Moens;Victoria Wang;Michelle Lenzi

  • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

    Winfried Edelmann;Kan Yang;Asad Umar;Joerg Heyer

  • Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

    Kaichun Wei;Alan B. Clark;Edmund Wong;Michael F. Kane

  • Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation

    Stephen Gray;Paula E. Cohen

  • RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis

    April Reynolds;Huanyu Qiao;Ye Yang;Jefferson K Chen

  • Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

    Ricardo Mouro Pinto;Ella Dragileva;Andrew Kirby;Andrew Kirby;Alejandro Lloret

  • Genetic recombination is targeted towards gene promoter regions in dogs.

    Adam Auton;Ying Rui Li;Jeffrey Kidd;Kyle Oliveira

  • Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.

    Michael A. Crackower;Nadine K. Kolas;Junko Noguchi;Renu Sarao

  • Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis.

    Meisha A Morelli;Paula E Cohen

  • MUS81 Generates a Subset of MLH1-MLH3–Independent Crossovers in Mammalian Meiosis

    J. Kim Holloway;James Booth;Winfried Edelmann;Clare H. McGowan

  • Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination

    Huanyu Qiao;H B D Prasada Rao;Ye Yang;Jared H Fong

  • Genetic Analysis of Chromosome Pairing, Recombination, and Cell Cycle Control during First Meiotic Prophase in Mammals

    P. E. Cohen;S. E. Pollack;J. W. Pollard

  • Extreme Heterogeneity in the Molecular Events Leading to the Establishment of Chiasmata during Meiosis I in Human Oocytes

    Michelle L. Lenzi;Jenetta Smith;Timothy Snowden;Mimi Kim

  • Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

    Nadine K. Kolas;Anton Svetlanov;Michelle L. Lenzi;Frank P. Macaluso

  • Macrophages: important accessory cells for reproductive function

    Paula E. Cohen;Kayoko Nishimura;Liyin Zhu;Jeffrey W. Pollard

  • Focus on Meiosis Not all germ cells are created equal: Aspects of sexual dimorphism in mammalian meiosis

    Meisha A Morelli;Paula E Cohen

Frequent Co-Authors

Jeffrey W. Pollard
Jeffrey W. Pollard University of Edinburgh
Winfried Edelmann
Winfried Edelmann Albert Einstein College of Medicine
Stephen K. Gray
Stephen K. Gray Victoria University
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego
Raju Kucherlapati
Raju Kucherlapati Harvard University
Peter B. Moens
Peter B. Moens York University
Steven M. Lipkin
Steven M. Lipkin Weill Cornell Medicine
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Matthew D. Scharff
Matthew D. Scharff Albert Einstein College of Medicine
Eric Alani
Eric Alani Cornell University

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