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Molecular Biology
Switzerland
2023

D-Index & Metrics

Molecular Biology

D-Index
87
Citations
25930
World Ranking
802
National Ranking
13

Research.com Recognitions

  • 2023 - Research.com Molecular Biology in Switzerland Leader Award
  • 2000 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Josef Jiricny is affiliated with the University of Zurich in Switzerland and contributes extensively to the fields of biochemistry, genetics, and molecular biology. Their research mainly focuses on molecular biology, pathology and forensic medicine, plant science, cancer research, and oncology.

The scientist has a significant publication record with numerous papers appearing in key venues such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Science Advances, Molecular and Cellular Biology, and Nucleic Acids Research.

Key recent publications include the following:

  • Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair, 2022, Nature Communications
  • FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats, 2021, Science Advances
  • Prime Editing Efficiency and Fidelity are Enhanced in the Absence of Mismatch Repair, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts, 2020, Nature Communications
  • FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair, 2021, Molecular and Cellular Biology

Their research covers several main topics, including:

  • DNA Repair Mechanisms
  • Genetic factors in colorectal cancer
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • Chromosomal and Genetic Variations
  • Cancer Genomics and Diagnostics
  • Fungal and yeast genetics research

Frequent collaborators include Serena Nik-Zainal, Gene Ching Chiek Koh, Xueqing Zou, Joana Ferreira da Silva, and Gonçalo P. Oliveira.

Josef Jiricny has been recognized by membership in scientific organizations such as the Academia Europaea since 2000 and the European Molecular Biology Organization (EMBO).

Best Publications

  • The multifaceted mismatch-repair system

    Josef Jiricny

  • The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

    Brian Hendrich;Ulrike Hardeland;Huck-Hui Ng;Josef Jiricny

  • GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

    Fabio Palombo;Paola Gallinari;Ingram Iaccarino;Teresa Lettieri

  • Mutations of GTBP in genetically unstable cells.

    Nickolas Papadopoulos;Nicholas C. Nicolaides;Bo Liu;Ramon Parsons

  • Transcriptome Profile of Human Colorectal Adenomas

    Jacob Sabates-Bellver;Laurens G Van der Flier;Mariagrazia de Palo;Elisa Cattaneo

  • Mismatch repair and DNA damage signalling.

    Lovorka Stojic;Richard Brun;Josef Jiricny

  • hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

    Fabio Palombo;Ingram Iaccarino;Eiitsu Nakajima;Miyoko Ikejima

  • Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

    Daniel Cortázar;Christophe Kunz;Jim Selfridge;Teresa Lettieri;Teresa Lettieri

  • Mismatch repair defects in cancer.

    Josef Jiricny;Minna Nyström-Lahti

  • Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

    M Höller;G Westin;J Jiricny;W Schaffner

  • Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

    Ulrike Hardeland;Roland Steinacher;Josef Jiricny;Primo Schär

  • Postreplicative Mismatch Repair

    Josef Jiricny

  • Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

    Katja Kratz;Barbara Schöpf;Svenja Kaden;Ataman Sendoel

  • Recent progress in the biology, chemistry and structural biology of DNA glycosylases.

    Orlando D. Schärer;Josef Jiricny

  • Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1

    Timothy R. Waters;Paola Gallinari;Josef Jiricny;Peter F. Swann

  • Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.

    Karin Wiebauer;Josef Jiricny

  • Conversion of diploidy to haploidy

    Hai Yan;Nickolas Papadopoulos;Giancarlo Marra;Claudia Perrera

  • Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase: Mismatch Recognition by Complementary-Strand Interactions

    Tracey E Barrett;Renos Savva;George Panayotou;Tom Barlow

  • Cloning and Expression of Human G/T Mismatch-specific Thymine-DNA Glycosylase

    Petra Neddermann;Paola Gallinari;Teresa Lettieri;Daniel Schmid

  • hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci.

    Hanna E. Kleczkowska;Giancarlo Marra;Teresa Lettieri;Teresa Lettieri;Josef Jiricny

Frequent Co-Authors

Giancarlo Marra
Giancarlo Marra University of Zurich
Serena Nik-Zainal
Serena Nik-Zainal University of Cambridge
Orlando D. Schärer
Orlando D. Schärer Institute for Basic Science
Laurence H. Pearl
Laurence H. Pearl University of Sussex
J. Justin Hsuan
J. Justin Hsuan University College London
Enzo Bonmassar
Enzo Bonmassar University of Rome Tor Vergata
Jean Benhattar
Jean Benhattar University of Lausanne
Stefano Ferrari
Stefano Ferrari Veneto Eye Bank Foundation
Päivi Peltomäki
Päivi Peltomäki University of Helsinki
Bert Vogelstein
Bert Vogelstein Johns Hopkins University

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