What is he best known for?
The fields of study he is best known for:
Molecular biology, DNA mismatch repair, Biochemistry, DNA and DNA glycosylase are his primary areas of study.
His Molecular biology study combines topics from a wide range of disciplines, such as DNA damage, DNA methylation, CpG site, DNA polymerase and Nuclear protein.
His DNA mismatch repair research incorporates elements of Mutation, Cancer research and DNA replication.
His research integrates issues of Primase, RNA Helicase A and dnaB helicase in his study of Biochemistry.
His DNA research focuses on subjects like Enzyme, which are linked to Structural biology.
His biological study spans a wide range of topics, including Base excision repair and Deamination.
His most cited work include:
- The multifaceted mismatch-repair system (912 citations)
- The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites (547 citations)
- GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells (465 citations)
What are the main themes of his work throughout his whole career to date?
Josef Jiricny focuses on DNA mismatch repair, Molecular biology, DNA, Genetics and DNA repair.
His study in DNA mismatch repair is interdisciplinary in nature, drawing from both Cancer research, Mutation, Nucleotide excision repair, Cell biology and DNA replication.
His work carried out in the field of Molecular biology brings together such families of science as Methylation, Exonuclease, DNA methylation, CpG site and MSH2.
DNA is a primary field of his research addressed under Biochemistry.
Josef Jiricny interconnects Replication protein A and Genome instability in the investigation of issues within DNA repair.
While the research belongs to areas of Deamination, Josef Jiricny spends his time largely on the problem of Thymine, intersecting his research to questions surrounding Base pair.
He most often published in these fields:
- DNA mismatch repair (53.59%)
- Molecular biology (43.06%)
- DNA (40.19%)
What were the highlights of his more recent work (between 2013-2021)?
- DNA mismatch repair (53.59%)
- DNA (40.19%)
- DNA repair (32.54%)
In recent papers he was focusing on the following fields of study:
Josef Jiricny mostly deals with DNA mismatch repair, DNA, DNA repair, DNA damage and Molecular biology.
His DNA mismatch repair research is multidisciplinary, incorporating perspectives in Computational biology and DNA replication.
Base excision repair and Nucleotide excision repair are the primary areas of interest in his DNA study.
His studies deal with areas such as Spindle apparatus, Chromosome segregation and Cytokinesis as well as DNA repair.
His DNA damage research includes elements of Chromatin, Poly ADP ribose polymerase and Homologous recombination.
His Molecular biology research is multidisciplinary, incorporating elements of Exonuclease, TATA box, Enhancer, DNA demethylation and CpG site.
Between 2013 and 2021, his most popular works were:
- FANCD2-associated Nuclease 1, but Not Exonuclease 1 or Flap Endonuclease 1, Is Able to Unhook DNA Interstrand Cross-links in Vitro (26 citations)
- FANCD2-associated Nuclease 1, but Not Exonuclease 1 or Flap Endonuclease 1, Is Able to Unhook DNA Interstrand Cross-links in Vitro (26 citations)
- FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 (20 citations)
In his most recent research, the most cited papers focused on:
Josef Jiricny mainly investigates DNA repair, FAN1, Molecular biology, Exonuclease and DNA mismatch repair.
His DNA repair study combines topics in areas such as Zinc finger, Cell biology, Chromosome instability, Cell Cycle Protein and DNA replication.
The study incorporates disciplines such as Proofreading, Coding strand, Mismatch Repair Endonuclease PMS2 and MutL Proteins in addition to DNA replication.
His FAN1 study contributes to a more complete understanding of DNA.
His DNA mismatch repair study deals with the bigger picture of Genetics.
His study focuses on the intersection of MSH6 and fields such as Mismatch Repair Protein with connections in the field of Cancer research.
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