Guo Min Li

What is he best known for?

The fields of study he is best known for:

• Gene
• DNA
• Mutation

Guo Min Li spends much of his time researching DNA mismatch repair, Genetics, DNA repair, Molecular biology and Nucleotide excision repair. His DNA mismatch repair research includes elements of DNA damage, DNA replication and Cell biology. His DNA replication research is multidisciplinary, relying on both Histone code, Chromatin, Histone H2A, Epigenomics and Cancer epigenetics.

His work on Colorectal cancer, Histone, Wild type and Allele is typically connected to Promoter as part of general Genetics study, connecting several disciplines of science. His Molecular biology course of study focuses on Mutation and Cancer research, Cell culture, DNA and Alzheimer's disease. His Nucleotide excision repair research incorporates elements of Processivity and Replication protein A.

His most cited work include:

• Hypermutability and mismatch repair deficiency in RER+ tumor cells (909 citations)
• Mechanisms and functions of DNA mismatch repair (794 citations)
• Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers (589 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include DNA mismatch repair, Genetics, Molecular biology, Cell biology and DNA repair. His DNA mismatch repair study combines topics in areas such as Cancer research, Nucleotide excision repair, DNA damage and DNA replication. He has researched DNA damage in several fields, including Apoptosis and Mutagenesis.

His work in DNA replication addresses subjects such as Trinucleotide repeat expansion, which are connected to disciplines such as Somatic cell. In Molecular biology, Guo Min Li works on issues like Replication protein A, which are connected to Control of chromosome duplication, DNA clamp and Eukaryotic DNA replication. His Cell biology research integrates issues from Chromatin, Nuclease and Proliferating cell nuclear antigen.

He most often published in these fields:

• DNA mismatch repair (86.96%)
• Genetics (42.03%)
• Molecular biology (34.78%)

What were the highlights of his more recent work (between 2017-2021)?

• DNA mismatch repair (86.96%)
• Cell biology (35.51%)
• Cancer research (25.36%)

In recent papers he was focusing on the following fields of study:

Guo Min Li focuses on DNA mismatch repair, Cell biology, Cancer research, Chromatin and DNA. His DNA mismatch repair study combines topics from a wide range of disciplines, such as Carcinogenesis and Microsatellite instability. His Cell biology study combines topics in areas such as Proliferating cell nuclear antigen, DNA synthesis and Nuclease.

His Cancer research research includes elements of Immune checkpoint, Cancer, Immunotherapy, MSH2 and Proteostasis. In his work, Genome instability, Methylation, Histone methyltransferase and Molecular biology is strongly intertwined with Histone methylation, which is a subfield of Chromatin. His DNA replication study introduces a deeper knowledge of Genetics.

Between 2017 and 2021, his most popular works were:

• ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade (149 citations)
• Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction. (35 citations)
• H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation (31 citations)

In his most recent research, the most cited papers focused on:

• Gene
• DNA
• Mutation

His primary areas of study are DNA mismatch repair, Gene, Cancer research, Chromatin and Histone H3. His DNA mismatch repair research includes themes of Histone, DNA replication, Mutation frequency and Cell biology. His work carried out in the field of DNA replication brings together such families of science as Protein kinase B, Signal transduction, Phosphorylation, DNA synthesis and Proliferating cell nuclear antigen.

His Mutation frequency study contributes to a more complete understanding of Genetics. He has included themes like RAD51, DNA, DNA repair and Exonuclease 1 in his Cancer research study. The various areas that Guo Min Li examines in his Chromatin study include Carcinogenesis, Methylation, Histone methylation and Genome instability.