D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 104 Citations 37,399 175 World Ranking 372 National Ranking 218

Research.com Recognitions

Awards & Achievements

2016 - Fellow, National Academy of Inventors

2015 - Nobel Prize for mechanistic studies of DNA repair

2004 - Fellow of the American Academy of Arts and Sciences

2003 - Member of the National Academy of Medicine (NAM)

1998 - Fellow of the American Association for the Advancement of Science (AAAS)

1998 - Robert J. and Claire Pasarow Foundation Medical Research Award

1996 - Charles S. Mott Prize, General Motors Cancer Research Foundation

1993 - Member of the National Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • DNA
  • Gene
  • Enzyme

His primary areas of study are DNA mismatch repair, MutS-1, Genetics, DNA repair and DNA. His research in DNA mismatch repair intersects with topics in Heteroduplex, DNA damage, Mutation, Base pair and Cell biology. His work deals with themes such as MutS DNA Mismatch-Binding Protein, Nucleotide excision repair and MutL Proteins, which intersect with MutS-1.

His Genetics research is multidisciplinary, incorporating elements of Computational biology and Tumor cells. He combines subjects such as Molecular biology and Genetic recombination with his study of DNA repair. In his research on the topic of DNA, Cytotoxic T cell is strongly related with Transversion.

His most cited work include:

  • Mismatch repair in replication fidelity, genetic recombination, and cancer biology. (1327 citations)
  • Hypermutability and mismatch repair deficiency in RER+ tumor cells (909 citations)
  • Mechanisms and biological effects of mismatch repair. (778 citations)

What are the main themes of his work throughout his whole career to date?

Paul Modrich mainly focuses on DNA mismatch repair, DNA, Molecular biology, Biochemistry and DNA repair. He works in the field of DNA mismatch repair, focusing on MutS-1 in particular. His research investigates the connection with MutS-1 and areas like MutL Proteins which intersect with concerns in MLH3.

His DNA research includes elements of Biophysics and Computational biology. His biological study spans a wide range of topics, including DNA clamp, Proliferating cell nuclear antigen, Mutant, Escherichia coli and DNA polymerase. His research integrates issues of DNA damage and Genome instability in his study of DNA repair.

He most often published in these fields:

  • DNA mismatch repair (71.79%)
  • DNA (47.86%)
  • Molecular biology (47.86%)

What were the highlights of his more recent work (between 2008-2020)?

  • DNA mismatch repair (71.79%)
  • DNA repair (34.62%)
  • DNA (47.86%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in DNA mismatch repair, DNA repair, DNA, Molecular biology and Endonuclease. His studies in DNA mismatch repair integrate themes in fields like Replication protein A, Nucleotide excision repair and Proliferating cell nuclear antigen. The various areas that he examines in his DNA repair study include Base pair and Cell biology.

His DNA study incorporates themes from Biophysics, Computational biology and Function. His study focuses on the intersection of Molecular biology and fields such as Cell with connections in the field of Null allele and Protein subunit. His Endonuclease study integrates concerns from other disciplines, such as PMS2, MutL Proteins, Genome instability and Binding site.

Between 2008 and 2020, his most popular works were:

  • BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair (484 citations)
  • PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair (197 citations)
  • Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family (115 citations)

In his most recent research, the most cited papers focused on:

  • DNA
  • Gene
  • Enzyme

Paul Modrich focuses on DNA mismatch repair, DNA repair, DNA, Replication protein A and Proliferating cell nuclear antigen. The concepts of his DNA mismatch repair study are interwoven with issues in Nucleotide excision repair and Endonuclease. His Endonuclease study improves the overall literature in Genetics.

The subject of his DNA repair research is within the realm of Biochemistry. His Biochemistry research integrates issues from Biophysics and Chromatin immunoprecipitation. His research in Proliferating cell nuclear antigen tackles topics such as Molecular biology which are related to areas like Exonuclease 1, Cell biology and Replication factor C.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Mismatch repair in replication fidelity, genetic recombination, and cancer biology.

Paul Modrich;Robert Lahue.
Annual Review of Biochemistry (1996)

1831 Citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

Ramon Parsons;Guo Min Li;Matthew J. Longley;Woei horng Fang;Woei horng Fang.
Cell (1993)

1283 Citations

Mechanisms and biological effects of mismatch repair.

Paul Modrich.
Annual Review of Genetics (1991)

1255 Citations

DNA mismatch repair: functions and mechanisms.

Ravi R Iyer;Anna Pluciennik;Vickers Burdett;Paul L Modrich.
Chemical Reviews (2006)

1009 Citations

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

Martina L. Veigl;Lakshmi Kasturi;Joseph Olechnowicz;Aihong Ma.
Proceedings of the National Academy of Sciences of the United States of America (1998)

830 Citations

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.

James T. Drummond;Guo Min Li;Matthew J. Longley;Paul Modrich.
Science (1995)

765 Citations

DNA mismatch correction in a defined system.

RS Lahue;KG Au;P Modrich.
Science (1989)

716 Citations

Endonucleolytic Function of MutLα in Human Mismatch Repair

Farid A. Kadyrov;Leonid Dzantiev;Nicoleta Constantin;Paul Modrich;Paul Modrich.
Cell (2006)

671 Citations

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair

Amitabh V. Nimonkar;Jochen Genschel;Eri Kinoshita;Piotr Polaczek.
Genes & Development (2011)

609 Citations

Mismatch repair, genetic stability, and cancer

Paul Modrich.
Science (1994)

587 Citations

If you think any of the details on this page are incorrect, let us know.

Contact us

Best Scientists Citing Paul Modrich

Richard D. Kolodner

Richard D. Kolodner

University of California, San Diego

Publications: 105

Josef Jiricny

Josef Jiricny

University of Zurich

Publications: 99

Thomas A. Kunkel

Thomas A. Kunkel

National Institutes of Health

Publications: 98

Guo Min Li

Guo Min Li

The University of Texas Southwestern Medical Center

Publications: 81

Richard Fishel

Richard Fishel

The Ohio State University

Publications: 81

Eric Alani

Eric Alani

Cornell University

Publications: 58

Winfried Edelmann

Winfried Edelmann

Albert Einstein College of Medicine

Publications: 56

Petr Cejka

Petr Cejka

Universita della Svizzera Italiana

Publications: 53

Aziz Sancar

Aziz Sancar

University of North Carolina at Chapel Hill

Publications: 49

Bert Vogelstein

Bert Vogelstein

Johns Hopkins University

Publications: 46

Martin G. Marinus

Martin G. Marinus

University of Massachusetts Medical School

Publications: 46

Päivi Peltomäki

Päivi Peltomäki

University of Helsinki

Publications: 44

Sanford D. Markowitz

Sanford D. Markowitz

Case Western Reserve University

Publications: 41

Miroslav Radman

Miroslav Radman

Université Paris Cité

Publications: 41

Giancarlo Marra

Giancarlo Marra

University of Zurich

Publications: 40

Stephen E. Halford

Stephen E. Halford

University of Bristol

Publications: 39

Trending Scientists

Tamas Linder

Tamas Linder

Queen's University

Michael F. Worboys

Michael F. Worboys

University of Greenwich

Jasbir S. Arora

Jasbir S. Arora

University of Iowa

Göran Lindbergh

Göran Lindbergh

Royal Institute of Technology

Gunnar Klemetsdal

Gunnar Klemetsdal

Norwegian University of Life Sciences

Ralph A. Giannella

Ralph A. Giannella

University of Cincinnati

Ute Hentschel

Ute Hentschel

GEOMAR Helmholtz Centre for Ocean Research Kiel

Michail V. Sitkovsky

Michail V. Sitkovsky

Northeastern University

Richard A. Depue

Richard A. Depue

Cornell University

Giovanni A. Fava

Giovanni A. Fava

State University of New York

Harold Snieder

Harold Snieder

University Medical Center Groningen

Chun-Su Yuan

Chun-Su Yuan

University of Chicago

Eric Boersma

Eric Boersma

Erasmus University Rotterdam

Eduardo Faerstein

Eduardo Faerstein

Rio de Janeiro State University

James Algina

James Algina

University of Florida

Benjamin D. Sommers

Benjamin D. Sommers

Harvard University

Something went wrong. Please try again later.