2016 - Fellow, National Academy of Inventors
2015 - Nobel Prize for mechanistic studies of DNA repair
2004 - Fellow of the American Academy of Arts and Sciences
2003 - Member of the National Academy of Medicine (NAM)
1998 - Fellow of the American Association for the Advancement of Science (AAAS)
1998 - Robert J. and Claire Pasarow Foundation Medical Research Award
1996 - Charles S. Mott Prize, General Motors Cancer Research Foundation
1993 - Member of the National Academy of Sciences
His primary areas of study are DNA mismatch repair, MutS-1, Genetics, DNA repair and DNA. His research in DNA mismatch repair intersects with topics in Heteroduplex, DNA damage, Mutation, Base pair and Cell biology. His work deals with themes such as MutS DNA Mismatch-Binding Protein, Nucleotide excision repair and MutL Proteins, which intersect with MutS-1.
His Genetics research is multidisciplinary, incorporating elements of Computational biology and Tumor cells. He combines subjects such as Molecular biology and Genetic recombination with his study of DNA repair. In his research on the topic of DNA, Cytotoxic T cell is strongly related with Transversion.
Paul Modrich mainly focuses on DNA mismatch repair, DNA, Molecular biology, Biochemistry and DNA repair. He works in the field of DNA mismatch repair, focusing on MutS-1 in particular. His research investigates the connection with MutS-1 and areas like MutL Proteins which intersect with concerns in MLH3.
His DNA research includes elements of Biophysics and Computational biology. His biological study spans a wide range of topics, including DNA clamp, Proliferating cell nuclear antigen, Mutant, Escherichia coli and DNA polymerase. His research integrates issues of DNA damage and Genome instability in his study of DNA repair.
His scientific interests lie mostly in DNA mismatch repair, DNA repair, DNA, Molecular biology and Endonuclease. His studies in DNA mismatch repair integrate themes in fields like Replication protein A, Nucleotide excision repair and Proliferating cell nuclear antigen. The various areas that he examines in his DNA repair study include Base pair and Cell biology.
His DNA study incorporates themes from Biophysics, Computational biology and Function. His study focuses on the intersection of Molecular biology and fields such as Cell with connections in the field of Null allele and Protein subunit. His Endonuclease study integrates concerns from other disciplines, such as PMS2, MutL Proteins, Genome instability and Binding site.
Paul Modrich focuses on DNA mismatch repair, DNA repair, DNA, Replication protein A and Proliferating cell nuclear antigen. The concepts of his DNA mismatch repair study are interwoven with issues in Nucleotide excision repair and Endonuclease. His Endonuclease study improves the overall literature in Genetics.
The subject of his DNA repair research is within the realm of Biochemistry. His Biochemistry research integrates issues from Biophysics and Chromatin immunoprecipitation. His research in Proliferating cell nuclear antigen tackles topics such as Molecular biology which are related to areas like Exonuclease 1, Cell biology and Replication factor C.
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Mismatch repair in replication fidelity, genetic recombination, and cancer biology.
Paul Modrich;Robert Lahue.
Annual Review of Biochemistry (1996)
Hypermutability and mismatch repair deficiency in RER+ tumor cells
Ramon Parsons;Guo Min Li;Matthew J. Longley;Woei horng Fang;Woei horng Fang.
Mechanisms and biological effects of mismatch repair.
Annual Review of Genetics (1991)
DNA mismatch repair: functions and mechanisms.
Ravi R Iyer;Anna Pluciennik;Vickers Burdett;Paul L Modrich.
Chemical Reviews (2006)
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
Martina L. Veigl;Lakshmi Kasturi;Joseph Olechnowicz;Aihong Ma.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
James T. Drummond;Guo Min Li;Matthew J. Longley;Paul Modrich.
DNA mismatch correction in a defined system.
RS Lahue;KG Au;P Modrich.
Endonucleolytic Function of MutLα in Human Mismatch Repair
Farid A. Kadyrov;Leonid Dzantiev;Nicoleta Constantin;Paul Modrich;Paul Modrich.
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair
Amitabh V. Nimonkar;Jochen Genschel;Eri Kinoshita;Piotr Polaczek.
Genes & Development (2011)
Mismatch repair, genetic stability, and cancer
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