2026 Paul Modrich: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	106	428	390	244	218	204	40159

Research.com Recognitions

2016 - Fellow, National Academy of Inventors
2015 - Nobel Prize for mechanistic studies of DNA repair
2004 - Fellow of the American Academy of Arts and Sciences
2003 - Member of the National Academy of Medicine (NAM)
1998 - Fellow of the American Association for the Advancement of Science (AAAS)
1998 - Robert J. and Claire Pasarow Foundation Medical Research Award
1996 - Charles S. Mott Prize, General Motors Cancer Research Foundation
1993 - Member of the National Academy of Sciences

Overview

Paul Modrich is affiliated with Duke University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, pathology and forensic medicine, genetics, cellular and molecular neuroscience, and geriatrics and gerontology.

Their work spans a range of topics including genetic factors in colorectal cancer, DNA repair mechanisms, genomics and chromatin dynamics, RNA and protein synthesis mechanisms, DNA and nucleic acid chemistry, genetic neurodegenerative diseases, and genomic variations and chromosomal abnormalities.

Frequent coauthors collaborating with Paul Modrich include Aziz Sancar, Farid A. Kadyrov, Elizabeth J. Sacho, Dorothy A. Erie, and Laura A. Lindsey-Boltz.

Modrich has published multiple papers in several venues, with a notable presence in UNC Libraries and Proceedings of the National Academy of Sciences. Some recent papers are:

Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion (2020), Proceedings of the National Academy of Sciences
MutL traps MutS at a DNA mismatch (2020), UNC Libraries
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System (2020), UNC Libraries
Direct Visualization of Asymmetric Adenine Nucleotide-Induced Conformational Changes in MutLα (2020), UNC Libraries
MutS mediates heteroduplex loop formation by a translocation mechanism (2020), UNC Libraries

Throughout their career, Paul Modrich has been recognized with several awards and memberships, including:

Nobel Prize in 2015 for mechanistic studies of DNA repair
Fellow, National Academy of Inventors (2016)
Fellow of the American Academy of Arts and Sciences (2004)
Member of the National Academy of Medicine (NAM) (2003)
Fellow of the American Association for the Advancement of Science (AAAS) (1998)
Robert J. and Claire Pasarow Foundation Medical Research Award (1998)
Charles S. Mott Prize, General Motors Cancer Research Foundation (1996)
Member of the National Academy of Sciences (1993)

Best Publications

Mismatch repair in replication fidelity, genetic recombination, and cancer biology.

Paul Modrich;Robert Lahue

1961
Citations
Hypermutability and mismatch repair deficiency in RER+ tumor cells

Ramon Parsons;Guo Min Li;Matthew J. Longley;Woei horng Fang;Woei horng Fang

1368
Citations
Mechanisms and biological effects of mismatch repair.

Paul Modrich

1328
Citations
DNA mismatch repair: functions and mechanisms.

Ravi R Iyer;Anna Pluciennik;Vickers Burdett;Paul L Modrich

1153
Citations
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

Martina L. Veigl;Lakshmi Kasturi;Joseph Olechnowicz;Aihong Ma

831
Citations
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair

Amitabh V. Nimonkar;Jochen Genschel;Eri Kinoshita;Piotr Polaczek

799
Citations
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells

James T. Drummond;Guo Min Li;Matthew J. Longley;Paul Modrich

779
Citations
DNA mismatch correction in a defined system.

RS Lahue;KG Au;P Modrich

779
Citations
Endonucleolytic Function of MutLα in Human Mismatch Repair

Farid A. Kadyrov;Leonid Dzantiev;Nicoleta Constantin;Paul Modrich;Paul Modrich

753
Citations
Mismatch repair, genetic stability, and cancer

Paul Modrich

635
Citations
Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha

Jochen Genschel;Susan J. Littman;James T. Drummond;Paul Modrich

589
Citations
Mechanisms in eukaryotic mismatch repair.

Paul Modrich

586
Citations
HUMAN MUTSALPHA RECOGNIZES DAMAGED DNA BASE PAIRS CONTAINING O6-METHYLGUANINE, O4-METHYLTHYMINE, OR THE CISPLATIN-D(GPG) ADDUCT

Derek R. Duckett;James T. Drummond;Alastair I. H. Murchie;Joyce T. Reardon

581
Citations
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

Alexandra Kat;William G. Thilly;Woei Horng Fang;Matthew J. Longley

561
Citations
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

Guo Min Li;Paul Modrich

535
Citations
DNA Mismatch Correction

Paul Modrich

535
Citations
Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

Jude Holmes;Susanna Clark;Paul Modrich

510
Citations
DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

HS Friedman;RE McLendon;T Kerby;M Dugan

507
Citations
Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

Shin-San Su;Paul Modrich

489
Citations
Methyl-directed repair of DNA base-pair mismatches in vitro

A L Lu;S Clark;P Modrich

479
Citations

Frequent Co-Authors

Guo Min Li The University of Texas Southwestern Medical Center

Darell D. Bigner Duke University

Henry S. Friedman Duke University

I. R. Lehman Stanford University

Aziz Sancar University of North Carolina at Chapel Hill

Lorena S. Beese Duke University

Francis Ali-Osman Duke University

Mike O'Donnell Rockefeller University

Bert Vogelstein Johns Hopkins University

Thomas Thundat University at Buffalo, State University of New York

External Links

Wikipedia of Paul Modrich Personal website of Paul Modrich

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