What is he best known for?
The fields of study he is best known for:
His primary areas of study are DNA mismatch repair, MutS-1, Genetics, DNA repair and DNA.
His research in DNA mismatch repair intersects with topics in Heteroduplex, DNA damage, Mutation, Base pair and Cell biology.
His work deals with themes such as MutS DNA Mismatch-Binding Protein, Nucleotide excision repair and MutL Proteins, which intersect with MutS-1.
His Genetics research is multidisciplinary, incorporating elements of Computational biology and Tumor cells.
He combines subjects such as Molecular biology and Genetic recombination with his study of DNA repair.
In his research on the topic of DNA, Cytotoxic T cell is strongly related with Transversion.
His most cited work include:
- Mismatch repair in replication fidelity, genetic recombination, and cancer biology. (1327 citations)
- Hypermutability and mismatch repair deficiency in RER+ tumor cells (909 citations)
- Mechanisms and biological effects of mismatch repair. (778 citations)
What are the main themes of his work throughout his whole career to date?
Paul Modrich mainly focuses on DNA mismatch repair, DNA, Molecular biology, Biochemistry and DNA repair.
He works in the field of DNA mismatch repair, focusing on MutS-1 in particular.
His research investigates the connection with MutS-1 and areas like MutL Proteins which intersect with concerns in MLH3.
His DNA research includes elements of Biophysics and Computational biology.
His biological study spans a wide range of topics, including DNA clamp, Proliferating cell nuclear antigen, Mutant, Escherichia coli and DNA polymerase.
His research integrates issues of DNA damage and Genome instability in his study of DNA repair.
He most often published in these fields:
- DNA mismatch repair (71.79%)
- DNA (47.86%)
- Molecular biology (47.86%)
What were the highlights of his more recent work (between 2008-2020)?
- DNA mismatch repair (71.79%)
- DNA repair (34.62%)
- DNA (47.86%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in DNA mismatch repair, DNA repair, DNA, Molecular biology and Endonuclease.
His studies in DNA mismatch repair integrate themes in fields like Replication protein A, Nucleotide excision repair and Proliferating cell nuclear antigen.
The various areas that he examines in his DNA repair study include Base pair and Cell biology.
His DNA study incorporates themes from Biophysics, Computational biology and Function.
His study focuses on the intersection of Molecular biology and fields such as Cell with connections in the field of Null allele and Protein subunit.
His Endonuclease study integrates concerns from other disciplines, such as PMS2, MutL Proteins, Genome instability and Binding site.
Between 2008 and 2020, his most popular works were:
- BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair (484 citations)
- PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair (197 citations)
- Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family (115 citations)
In his most recent research, the most cited papers focused on:
Paul Modrich focuses on DNA mismatch repair, DNA repair, DNA, Replication protein A and Proliferating cell nuclear antigen.
The concepts of his DNA mismatch repair study are interwoven with issues in Nucleotide excision repair and Endonuclease.
His Endonuclease study improves the overall literature in Genetics.
The subject of his DNA repair research is within the realm of Biochemistry.
His Biochemistry research integrates issues from Biophysics and Chromatin immunoprecipitation.
His research in Proliferating cell nuclear antigen tackles topics such as Molecular biology which are related to areas like Exonuclease 1, Cell biology and Replication factor C.
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