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Francis Ali-Osman

Francis Ali-Osman

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
11056
World Ranking
12686
National Ranking
5407

Overview

Francis Ali-Osman is affiliated with Duke University in the United States. Their research spans multiple areas within medicine, with a particular emphasis on surgery and genetics, as well as cancer research and hematology. The scientist's work intersects with emergency medicine and involves detailed studies in trauma management and diagnosis, spinal fractures and fixation techniques, and glioma diagnosis and treatment.

Francis Ali-Osman has authored several papers published in notable venues, including:

  • Outcome after surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures and moderate to severe traumatic brain injury (2020), published in The Journal of Trauma: Injury, Infection, and Critical Care
  • European genetic ancestry associated with risk of childhood ependymoma (2020), published in Neuro-Oncology
  • Surgical stabilization versus nonoperative treatment for flail and non-flail rib fracture patterns in patients with traumatic brain injury (2022), published in European Journal of Trauma and Emergency Surgery
  • A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-kit-positive Acute Myeloid Leukemia (2020), published in Clinical Lymphoma Myeloma & Leukemia
  • Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development (2020), published in UNC Libraries

The scientist frequently collaborates with peers such as Jonne T.H. Prins, Esther M.M. Van Lieshout, Zachary M. Bauman, Eva-Corina Caragounis, and Jeff Choi. These co-authorships reflect an active engagement in multidisciplinary research teams.

Francis Ali-Osman's primary fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

The subfields of their research cover:

  • Surgery
  • Genetics
  • Cancer Research
  • Hematology
  • Emergency Medicine

The main topics that characterize Francis Ali-Osman's work are:

  • Trauma Management and Diagnosis
  • Spinal Fractures and Fixation Techniques
  • Glioma Diagnosis and Treatment
  • Trauma and Emergency Care Studies
  • Genetics and Neurodevelopmental Disorders
  • MicroRNA in disease regulation
  • Traumatic Ocular and Foreign Body Injuries

Best Publications

  • Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants EVIDENCE FOR DIFFERENTIAL CATALYTIC ACTIVITY OF THE ENCODED PROTEINS

    Francis Ali-Osman;Olanike Akande;Gamil Antoun;Jia-Xi Mao

  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells : molecular characterization of glutathione-platinum complex and its biological significance

    T Ishikawa;F Ali-Osman

  • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis.

    Tongxin Xie;Daoyan Wei;Mingguang Liu;Allen C. Gao

  • Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

    Beatrice S Melin;Jill S Barnholtz-Sloan;Margaret R Wrensch;Christoffer Johansen

  • Ubiquitination-Dependent Proteolysis of O6-Methylguanine-DNA Methyltransferase in Human and Murine Tumor Cells following Inactivation with O6-Benzylguanine or 1,3-Bis(2-chloroethyl)-1-nitrosourea†

    Kalkunte S. Srivenugopal;Xiao-Hua Yuan;Henry S. Friedman;Francis Ali-Osman

  • Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance

    Hui-Wen Lo;Francis Ali-Osman

  • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators.

    Hui-Wen Lo;Xinyu Cao;Hu Zhu;Francis Ali-Osman

  • Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes

    Hui-Wen Lo;Xinyu Cao;Hu Zhu;Francis Ali-Osman

  • Germline mutations in shelterin complex genes are associated with familial glioma.

    Matthew N. Bainbridge;Georgina N. Armstrong;M. Monica Gramatges;Alison A. Bertuch

  • Selective Suppression of Matrix Metalloproteinase-9 in Human Glioblastoma Cells by Antisense Gene Transfer Impairs Glioblastoma Cell Invasion

    Sudha Kondraganti;Sanjeeva Mohanam;Shravan K. Chintala;Yoshiaki Kin

  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.

    Jiang Shou;Francis Ali-Osman;Asha S Multani;Sen Pathak

  • Modulation of in Vitro Invasion of Human Glioblastoma Cells by Urokinase-type Plasminogen Activator Receptor Antibody

    Sanjeeva Mohanam;Raymond E Sawaya;Ian E McCutcheon;Francis Ali-Osman

  • A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

    Hui-Wen Lo;Hu Zhu;Xinyu Cao;Amy Aldrich

  • Methylator Resistance Mediated by Mismatch Repair Deficiency in a Glioblastoma Multiforme Xenograft

    Henry S. Friedman;Stewart P. Johnson;Qing Dong;S. Clifford Schold

  • Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft

    C. Lynn Cheng;Stewart P. Johnson;Stephen T. Keir;Jennifer A. Quinn

  • Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas.

    Francis Ali-Osman;Janet M. Brunner;Tetzer M. Kutluk;Kenneth Hess

  • Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage

    Ameya Paranjpe;Ruiwen Zhang;Francis Ali-Osman;George C. Bobustuc

  • Glutathione Content and Glutathione-S-transferase Expression in 1,3-Bis(2-chloroethyl)-1-nitrosourea-resistant Human Malignant Astrocytoma Cell Lines

    Francis Ali-Osman;Donna E. Stein;Alexander Renwick

  • Genomic and Molecular Profiling Predicts Response to Temozolomide in Melanoma

    Christina K. Augustine;Jin Soo Yoo;Anil Potti;Yasunori Yoshimoto

  • Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study.

    E. Susan Amirian;Renke Zhou;Margaret R. Wrensch;Sara H. Olson

Frequent Co-Authors

Henry S. Friedman
Henry S. Friedman Duke University
Darell D. Bigner
Darell D. Bigner Duke University
Margaret R. Wrensch
Margaret R. Wrensch University of California, San Francisco
Melissa L. Bondy
Melissa L. Bondy Stanford University
Jill S. Barnholtz-Sloan
Jill S. Barnholtz-Sloan Case Western Reserve University
Raymond Sawaya
Raymond Sawaya The University of Texas MD Anderson Cancer Center
Joellen M. Schildkraut
Joellen M. Schildkraut University of Virginia
Christopher I. Amos
Christopher I. Amos Baylor College of Medicine
Richard S. Houlston
Richard S. Houlston Institute of Cancer Research

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