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Darell D. Bigner

Darell D. Bigner

D-Index & Metrics

Medicine

D-Index
159
Citations
142407
World Ranking
798
National Ranking
451

Overview

Darell D. Bigner is affiliated with Duke University in the United States. Their research activity spans multiple fields, including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these broader areas, Darell's work features subfields such as Immunology, Oncology, Molecular Biology, Genetics, and Cancer Research.

The main topics covered in Darell's research portfolio include:

  • CAR-T cell therapy research
  • Glioma Diagnosis and Treatment
  • Immunotherapy and Immune Responses
  • Cancer Research and Treatments
  • Virus-based gene therapy research
  • Interferon and immune responses
  • Immune cells in cancer

Darell has published extensively in scientific journals, with a number of recent papers demonstrating their research focus and collaborative work. Notable papers include:

  • Pan-cancer analysis of whole genomes, 2020, published in Nature
  • Divergent mutational processes distinguish hypoxic and normoxic tumours, 2020, Nature Communications
  • Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy, 2021, Nature Communications
  • Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma, 2021, Journal for ImmunoTherapy of Cancer
  • Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition, 2022, Cancer Cell

The scientist frequently publishes in several venues, highlighting their active engagement in specific research communities. These venues include:

  • Neuro-Oncology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal for ImmunoTherapy of Cancer
  • UNC Libraries

Darell collaborates regularly with a number of coauthors, reflecting a network of academic partnerships. Frequent coauthors include:

  • David M. Ashley
  • Matthias Gromeier
  • Annick Desjardins
  • Michael C. Brown
  • James E. Herndon

The breadth of Darell D. Bigner's research contributions combines clinical and molecular insights, particularly in cancer, immunology, and gene therapy areas. Their work involves both experimental and translational approaches aimed at understanding tumors, immune response mechanisms, and therapeutic strategies.

Best Publications

  • Mutations of the BRAF gene in human cancer

    Helen Davies;Graham R. Bignell;Charles Cox;Philip Stephens

  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

    Shideng Bao;Qiulian Wu;Roger E McLendon;Yueling Hao

  • An Integrated Genomic Analysis of Human Glioblastoma Multiforme

    D. Williams Parsons;Siân Jones;Xiaosong Zhang;Jimmy Cheng-Ho Lin

  • IDH1 and IDH2 Mutations in Gliomas

    Hai Yan;D. Williams Parsons;Genglin Jin;Roger McLendon

  • The Somatic Genomic Landscape of Glioblastoma

    Cameron W. Brennan;Roel G W Verhaak;Aaron McKenna;Benito Campos

  • The Immune Landscape of Cancer

    Vésteinn Thorsson;David L Gibbs;Scott D Brown;Denise Wolf

  • Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

    Daniel J. Brat;Roel G.W. Verhaak;Kenneth D. Aldape;W. K.Alfred Yung

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas

    Francisco Sanchez-Vega;Marco Mina;Joshua Armenia;Walid K. Chatila

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Bevacizumab Plus Irinotecan in Recurrent Glioblastoma Multiforme

    James J. Vredenburgh;Annick Desjardins;James E. Herndon;Jennifer Marcello

  • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

    Shideng Bao;Qiulian Wu;Sith Sathornsumetee;Yueling Hao

  • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

    Patrick J. Killela;Zachary J. Reitman;Yuchen Jiao;Chetan Bettegowda

  • Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma

    James J. Vredenburgh;Annick Desjardins;James E. Herndon;Jeannette M. Dowell

  • Altered Telomeres in Tumors with ATRX and DAXX Mutations

    Christopher M. Heaphy;Roeland F. de Wilde;Yuchen Jiao;Alison P. Klein

  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy

    Alison M. Taylor;Alison M. Taylor;Juliann Shih;Gavin Ha;Gavin Ha;Galen F. Gao

  • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

    Albert J. Wong;Sandra H. Bigner;Darell D. Bigner;Kenneth W. Kinzler

  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Paul A. Northcott;Paul A. Northcott;David J.H. Shih;John Peacock;Livia Garzia

  • TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL

    Hai Yan;P.J. Killela;Z.J. Reitman;Y. Jiao

  • The somatic genomic landscape of glioblastoma

    Cameron W. Brennan;Roel G. W. Verhaak;Aaron Mckenna;Benito Campos

Frequent Co-Authors

Henry S. Friedman
Henry S. Friedman Duke University
Roger E. McLendon
Roger E. McLendon Duke University
John H. Sampson
John H. Sampson Duke University
Allan H. Friedman
Allan H. Friedman Duke University
James E. Herndon
James E. Herndon Duke University
Michael R. Zalutsky
Michael R. Zalutsky Duke University
Gary E. Archer
Gary E. Archer Duke University
David A. Reardon
David A. Reardon Harvard University
Jeremy N. Rich
Jeremy N. Rich University of Pittsburgh
Bert Vogelstein
Bert Vogelstein Johns Hopkins University

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