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Medicine

D-Index
116
Citations
46210
World Ranking
4379
National Ranking
2393

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Paul S. Mischel is affiliated with Stanford University in the United States and specializes primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research contributions focus extensively on molecular biology, cancer research, and genetics, with additional work in pathology, forensic medicine, and surgery.

The areas of study Paul S. Mischel has concentrated on include:

  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Glioma Diagnosis and Treatment
  • Genomics and Chromatin Dynamics
  • CRISPR and Genetic Engineering
  • Single-cell and spatial transcriptomics

Among the notable recent papers authored by Paul S. Mischel are:

  • Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers, 2020, Nature Genetics
  • ecDNA hubs drive cooperative intermolecular oncogene expression, 2021, Nature
  • Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus, 2023, Nature
  • The evolutionary dynamics of extrachromosomal DNA in human cancers, 2022, Nature Genetics
  • Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA, 2022, Nature

Paul S. Mischel has published extensively in several venues, with the most frequent being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature
  • Nature Communications
  • Nature Genetics

They have collaborated frequently with several researchers, including:

  • Vineet Bafna
  • Jens Luebeck
  • Howard Y. Chang
  • Ivy Tsz-Lo Wong
  • Sihan Wu

Their scholarly output is predominantly concentrated in molecular biology and cancer research, reflecting significant engagement with genetics and diagnostic methods in oncology.

Paul S. Mischel has received recognition in the form of awards such as being named Fellow of the American Association for the Advancement of Science (AAAS) in 2015 and membership in the Association of American Physicians.

Best Publications

  • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

    Ingo K. Mellinghoff;Maria Y. Wang;Igor Vivanco;Daphne A. Haas-Kogan

  • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

    Andrew T Parsa;James S Waldron;Amith Panner;Courtney A Crane

  • Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

    Rameen Beroukhim;Gad Getz;Leia Nghiemphu;Jordi Barretina

  • High-throughput oncogene mutation profiling in human cancer

    Roman K. Thomas;Alissa C. Baker;Ralph M. DeBiasi;Ralph M. DeBiasi;Wendy Winckler;Wendy Winckler

  • Gene Expression Profiling of Gliomas Strongly Predicts Survival

    William A. Freije;F. Edmundo Castro-Vargas;Zixing Fang;Steve Horvath

  • Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

    S. Horvath;B. Zhang;M. Carlson;K. V. Lu

  • Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

    Tim F Cloughesy;Koji Yoshimoto;Phioanh Leia Nghiemphu;Kevin Brown

  • Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

    Kristen M. Turner;Viraj Deshpande;Doruk Beyter;Tomoyuki Koga

  • LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

    David B. Shackelford;David B. Shackelford;Evan Abt;Laurie Gerken;Debbie S. Vasquez

  • Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment

    Linda M. Liau;Robert M. Prins;Sylvia M. Kiertscher;Sylvia K. Odesa

  • Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.

    David A. Nathanson;Beatrice Gini;Jack Mottahedeh;Koppany Visnyei

  • Glioblastoma: From Molecular Pathology to Targeted Treatment

    Timothy F. Cloughesy;Webster K. Cavenee;Paul S. Mischel

  • Analysis of the Phosphatidylinositol 3′-Kinase Signaling Pathway in Glioblastoma Patients in Vivo

    Gheeyoung Choe;Steve Horvath;Timothy F. Cloughesy;Katherine Crosby

  • Metabolic state of glioma stem cells and nontumorigenic cells

    Erina Vlashi;Chann Lagadec;Laurent Vergnes;Tomoo Matsutani

  • Cerebral Cortical Dysplasia Associated with Pediatric Epilepsy. Review of Neuropathologic Features and Proposal for a Grading System

    Paul S. Mischel;Loan P. Nguyen;Harry V. Vinters

  • Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme

    Albert Lai;Anh Tran;Phioanh L. Nghiemphu;Whitney B. Pope

  • Imaging Proliferation in Brain Tumors with 18F-FLT PET: Comparison with 18F-FDG

    Wei Chen;Timothy Cloughesy;Nirav Kamdar;Nagichettiar Satyamurthy

  • Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

    Albert Lai;Samir Kharbanda;Whitney B. Pope;Anh Tran

  • MR imaging correlates of survival in patients with high-grade gliomas

    Whitney B. Pope;James Sayre;Alla Perlina;J. Pablo Villablanca

  • Single-cell analysis tools for drug discovery and development

    James R. Heath;Antoni Ribas;Paul S. Mischel

Frequent Co-Authors

Timothy F. Cloughesy
Timothy F. Cloughesy University of California, Los Angeles
Linda M. Liau
Linda M. Liau University of California, Los Angeles
Webster K. Cavenee
Webster K. Cavenee University of California, San Diego
Frank B. Furnari
Frank B. Furnari University of California, San Diego
Ingo K. Mellinghoff
Ingo K. Mellinghoff Memorial Sloan Kettering Cancer Center
Stanley F. Nelson
Stanley F. Nelson University of California, Los Angeles
Albert Lai
Albert Lai University of Washington
Vineet Bafna
Vineet Bafna University of California, San Diego
Harry V. Vinters
Harry V. Vinters University of California, Los Angeles
Steve Horvath
Steve Horvath University of California, Los Angeles

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