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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
137
Citations
102579
World Ranking
314
National Ranking
211

Medicine

D-Index
137
Citations
102596
World Ranking
1860
National Ranking
1057

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2022 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2012 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Human Genetics and Molecular Medicine
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2007 - Szent-Györgyi Prize for Progress in Cancer Research, National Foundation for Cancer Research (NFCR)
  • 2007 - Member of the National Academy of Medicine (NAM)
  • 1997 - Member of the National Academy of Sciences
  • 1990 - Charles S. Mott Prize, General Motors Cancer Research Foundation

Overview

Webster K. Cavenee is affiliated with the University of California, San Diego in the United States. Their research spans fields including biochemistry, genetics, molecular biology, and medicine, with a notable focus on molecular biology, genetics, cancer research, oncology, and statistics and probability.

Their scientific contributions are evident in their engagement with topics such as glioma diagnosis and treatment, cancer genomics and diagnostics, statistical methods in clinical trials, epigenetics and DNA methylation, histone deacetylase inhibitors research, Hippo pathway signaling and YAP/TAZ, as well as cancer, hypoxia, and metabolism.

Frequent publication venues for their work include:

  • Neuro-Oncology
  • Proceedings of the National Academy of Sciences
  • Journal of Clinical Oncology
  • UNC Libraries
  • Journal of Clinical Investigation

Collaborative research has involved multiple co-authors with repeated joint publications. Regular co-authors include:

  • Timothy F. Cloughesy
  • Patrick Y. Wen
  • Mustafa Khasraw
  • Ingo K. Mellinghoff
  • Michael Weller

Selected recent papers illustrate the range of their scientific inquiry:

  • "Tumour predisposition and cancer syndromes as models to study gene-environment interactions," 2020, Nature Reviews. Cancer
  • "Immune evasion in HPVhead and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss," 2021, Proceedings of the National Academy of Sciences
  • "Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM," 2020, Molecular Cancer Research
  • "Lumefantrine, an antimalarial drug, reverses radiation and temozolomide resistance in glioblastoma," 2020, Proceedings of the National Academy of Sciences
  • "MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis," 2020, Pharmacological Research

Throughout their career, they have received several awards including:

  • German National Academy of Sciences Leopoldina, 2012, for Human Genetics and Molecular Medicine
  • Fellow of the American Association for the Advancement of Science (AAAS), 2008
  • Member of the National Academy of Medicine (NAM), 2007
  • Szent-Györgyi Prize for Progress in Cancer Research, National Foundation for Cancer Research (NFCR), 2007
  • Member of the National Academy of Sciences, 1997
  • Charles S. Mott Prize, General Motors Cancer Research Foundation, 1990

Best Publications

  • The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

    David N. Louis;Arie Perry;Guido Reifenberger;Andreas von Deimling

  • The 2007 WHO Classification of Tumours of the Central Nervous System

    David Neil Louis;Hiroko Ohgaki;Otmar D. Wiestler;Webster K. Cavenee

  • The WHO Classification of Tumors of the Nervous System

    Paul Kleihues;David N. Louis;Bernd W. Scheithauer;Lucy B. Rorke

  • Malignant astrocytic glioma: genetics, biology, and paths to treatment.

    Frank B. Furnari;Tim Fenton;Robert M. Bachoo;Akitake Mukasa

  • Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

    W. K. Cavenee;W. K. Cavenee;T. P. Dryja;R. A. Phillips;William F Benedict

  • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

    Joseph F. Costello;Joseph F. Costello;Michael C. Frühwald;Michael C. Frühwald;Dominic J. Smiraglia;Laura J. Rush

  • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

    Ingo K. Mellinghoff;Maria Y. Wang;Igor Vivanco;Daphne A. Haas-Kogan

  • Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

    Manfred Gessler;Annemarie Poustka;Webster Cavenee;Rachael L. Neve

  • Malignant glioma: Genetics and biology of a grave matter

    Elizabeth A. Maher;Frank B. Furnari;Robert M. Bachoo;David H. Rowitch

  • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.

    William H. Biggs;Jill Meisenhelder;Tony Hunter;Webster K. Cavenee

  • Erratum: The 2007 WHO classification of tumours of the central nervous system (Acta Neuropathol (2007) vol. 114 (97-109))

    David N Louis;Hiroko Ohgaki;Otmar D Wiestler;Webster K Cavenee

  • A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

    R Nishikawa;X D Ji;R C Harmon;C S Lazar

  • Structure, Chromosomal Localization, and Expression of 12 Genes of the Mage Family

    Etienne De Plaen;Etienne De Plaen;Catia Traversari;Catia Traversari;José J.J. Gaforio;José J.J. Gaforio;Jean Pierre Szikora;Jean Pierre Szikora

  • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling.

    H.-J. Su Huang;Motoo Nagane;Candice K. Klingbeil;Hong Lin

  • Genes for Epidermal Growth Factor Receptor, Transforming Growth Factor α, and Epidermal Growth Factor and Their Expression in Human Gliomas in Vivo

    A J Ekstrand;C D James;W K Cavenee;B Seliger

  • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

    Jun Nakae;William H. Biggs;Tadahiro Kitamura;Webster K. Cavenee

  • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

    Taisuke Hosaka;William H. Biggs;David Tieu;Antonia D. Boyer

  • Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.

    A. Koufos;M. F. Hansen;B. C. Lampkin;M. L. Workman

  • A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

    Zirong Li;Sara Van Calcar;Chunxu Qu;Webster K. Cavenee

  • Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.

    Alex Koufos;Alex Koufos;Marc F. Hansen;Neal G. Copeland;Nancy A. Jenkins

Frequent Co-Authors

Frank B. Furnari
Frank B. Furnari University of California, San Diego
Paul S. Mischel
Paul S. Mischel Stanford University
Karen C. Arden
Karen C. Arden University of California, San Diego
Timothy F. Cloughesy
Timothy F. Cloughesy University of California, Los Angeles
Terrance Grant Johns
Terrance Grant Johns Telethon Kids Institute
Shi Yuan Cheng
Shi Yuan Cheng Northwestern University
Andrew M. Scott
Andrew M. Scott La Trobe University
Scott R. VandenBerg
Scott R. VandenBerg University of California, San Francisco
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
Wadih Arap
Wadih Arap Rutgers, The State University of New Jersey

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