World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
105
Citations
44036
World Ranking
6733
National Ranking
3553

Overview

C. David James is affiliated with Northwestern University in the United States. Their research spans the fields of biochemistry, genetics, molecular biology, and medicine, with a focused expertise in molecular biology, genetics, immunology, oncology, and neurology.

The scientist's work covers several main topics, including:

  • Glioma diagnosis and treatment
  • Immune cells in cancer
  • Neuroinflammation and neurodegeneration mechanisms
  • Epigenetics and DNA methylation
  • CAR-T cell therapy research
  • Histone deacetylase inhibitors research
  • Cancer research and treatments

Frequent co-authors collaborating with C. David James include:

  • Craig Horbinski
  • Amy B. Heimberger
  • Maciej S. Lesniak
  • Hinda Najem
  • Atique U. Ahmed

The scientist has published extensively in several venues, with the most frequent including:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • Clinical Cancer Research
  • Cancers

Recent papers authored by C. David James demonstrate involvement in clinical and molecular cancer research, particularly related to glioblastoma and cancer resistance mechanisms. Notable publications include:

  • "A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma," 2021, Science Translational Medicine
  • "Context-Dependent Glioblastoma-Macrophage/Microglia Symbiosis and Associated Mechanisms," 2021, Trends in Immunology
  • "PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells," 2021, Molecular Cell
  • "Review of gas emissions from lithium-ion battery thermal runaway failure - Considering toxic and flammable compounds," 2024, Journal of Energy Storage
  • "De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma," 2021, Brain

Best Publications

  • Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

    Roel G. W. Verhaak;Katherine A. Hoadley;Elizabeth Purdom;Victoria Wang

  • miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.

    Joachim Silber;Daniel A Lim;Claudia Petritsch;Anders I Persson

  • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

    Lori Frederick;Xiao Yang Wang;Greg Eley;C. David James

  • PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

    Justin S. Smith;Issei Tachibana;Sandra M. Passe;Brenda K. Huntley

  • Sporadic Medulloblastomas Contain PTCH Mutations

    Corey Raffel;Robert B. Jenkins;Lori Frederick;Deanne Hebrink

  • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

    Kui Ming Chan;Dong Fang;Haiyun Gan;Rintaro Hashizume

  • A hierarchy of self-renewing tumor-initiating cell types in glioblastoma

    Ruihuan Chen;Merry C. Nishimura;Stephanie M. Bumbaca;Samir Kharbanda

  • Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.

    David A. Nathanson;Beatrice Gini;Jack Mottahedeh;Koppany Visnyei

  • Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

    David A. Solomon;Taeyeon Kim;Laura A. Diaz-Martinez;Joshlean Fair

  • Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

    Albert Lai;Samir Kharbanda;Whitney B. Pope;Anh Tran

  • Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

    Rintaro Hashizume;Noemi Andor;Yuichiro Ihara;Robin Lerner

  • An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

    Deliang Guo;Felicia Reinitz;Mary Youssef;Cynthia Hong

  • Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

    Andrea Piunti;Rintaro Hashizume;Marc A. Morgan;Elizabeth T. Bartom

  • Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

    Jann N. Sarkaria;Gaspar J. Kitange;C. David James;Ruth Plummer

  • An overview of meningiomas.

    Robin A Buerki;Craig M Horbinski;Timothy Kruser;Peleg M Horowitz

  • Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

    Michael D. Prados;Susan M. Chang;Nicholas Butowski;Rebecca DeBoer

  • Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

    Gaspar J. Kitange;Brett L. Carlson;Mark A. Schroeder;Patrick T. Grogan

  • Epidermal Growth Factor Receptor Variant III Status Defines Clinically Distinct Subtypes of Glioblastoma

    Christopher E. Pelloski;Karla V. Ballman;Alfred F. Furth;Li Zhang

  • Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations

    Wanguo Liu;David I. Smith;Keri J. Rechtzigel;Stephen N. Thibodeau

  • Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme.

    Caterina Giannini;Jann N. Sarkaria;Atsushi Saito;Joon H. Uhm

Frequent Co-Authors

Craig Horbinski
Craig Horbinski Northwestern University
Mitchel S. Berger
Mitchel S. Berger University of California, San Francisco
Michael D. Prados
Michael D. Prados University of California, San Francisco
Jann N. Sarkaria
Jann N. Sarkaria Mayo Clinic
Joanna J. Phillips
Joanna J. Phillips University of California, San Francisco
Atique U. Ahmed
Atique U. Ahmed Northwestern University
Nalin Gupta
Nalin Gupta University of California, San Francisco
Scott R. VandenBerg
Scott R. VandenBerg University of California, San Francisco
Shi Yuan Cheng
Shi Yuan Cheng Northwestern University

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