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Medicine

D-Index
108
Citations
51961
World Ranking
5925
National Ranking
3173

Overview

W. K. Alfred Yung is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily focuses on medicine, with significant contributions to biochemistry, genetics, and molecular biology. The scientist's work spans various subfields including genetics, pulmonary and respiratory medicine, molecular biology, oncology, and cancer research.

The main topics addressed by their publications include:

  • Glioma Diagnosis and Treatment
  • Brain Metastases and Treatment
  • Cancer Genomics and Diagnostics
  • Immune cells in cancer
  • DNA Repair Mechanisms
  • Health Systems, Economic Evaluations, Quality of Life
  • COVID-19 and healthcare impacts

Yung has an extensive publication record with frequent contributions to journals, particularly Neuro-Oncology, where they have published 14 papers. Other notable venues include the Journal of Clinical Oncology with 4 papers, Neuro-Oncology Advances with 2 papers, and individual publications in Nature Genetics and Nature Communications.

Selected recent publications include:

  • Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma (2023, Journal of Clinical Oncology)
  • The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location (2022, Nature Genetics)
  • PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma (2021, Neuro-Oncology)
  • Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation (2021, Nature Communications)
  • A Bayesian adaptive randomized phase II multicenter trial of bevacizumab with or without vorinostat in adults with recurrent glioblastoma (2020, Neuro-Oncology)

The scientist collaborates frequently with several co-authors. Among them are Patrick Y. Wen, John de Groot, Vinay K. Puduvalli, Shiao-Pei Weathers, and Timothy F. Cloughesy, each having co-authored multiple papers alongside Yung.

Best Publications

  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways

    Roger McLendon;Allan Friedman;Darrell Bigner;Erwin G. Van Meir

  • Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

    Daniel J. Brat;Roel G.W. Verhaak;Kenneth D. Aldape;W. K.Alfred Yung

  • Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

    Henry S. Friedman;Michael D. Prados;Patrick Y. Wen;Tom Mikkelsen

  • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.

    Michele Ceccarelli;Floris P Barthel;Tathiane M Malta;Thais S Sabedot

  • A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

    W K A Yung;R E Albright;J Olson;R Fredericks

  • Outcomes and Prognostic Factors in Recurrent Glioma Patients Enrolled Onto Phase II Clinical Trials

    Eric T. Wong;Kenneth R. Hess;Mary Jo Gleason;Kurt A. Jaeckle

  • A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

    Juan Fueyo;Candelaria Gomez-Manzano;Ramon Alemany;Polly S.Y. Lee

  • Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse

    W. K.Alfred Yung;Michael D. Prados;Ricardo Yaya-Tur;Steven S. Rosenfeld

  • PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

    Weiwei Yang;Yan Xia;David Hawke;Xinjian Li

  • Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials

    Benjamin M. Ellingson;Martin Bendszus;Martin Bendszus;Jerrold Boxerman;Daniel Barboriak

  • MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

    David H.F. Teng;Rong Hu;Huai Lin;Thaylon Davis

  • FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

    Nu Zhang;Nu Zhang;Ping Wei;Ping Wei;Aihua Gong;Wen Tai Chiu

  • Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.

    Frederick F Lang;Charles Conrad;Candelaria Gomez-Manzano;W K Alfred Yung

  • Phase II Trial of the Antiangiogenic Agent Thalidomide in Patients With Recurrent High-Grade Gliomas

    Howard A. Fine;William D. Figg;Kurt Jaeckle;Patrick Y. Wen

  • Phase I/II Study of Imatinib Mesylate for Recurrent Malignant Gliomas: North American Brain Tumor Consortium Study 99-08

    Patrick Y. Wen;W. K Alfred Yung;Kathleen R. Lamborn;Patricia L. Dahia

  • Phase I Trial of Adenovirus-Mediated p53 Gene Therapy for Recurrent Glioma: Biological and Clinical Results

    Frederick F. Lang;Janet M. Bruner;Gregory N. Fuller;Kenneth Aldape

  • Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas.

    Kathleen R. Lamborn;W. K.Alfred Yung;Susan M. Chang;Patrick Y. Wen

  • Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.

    Tetsuro Sano;Huai Lin;Xiashan Chen;Lauren A. Langford

  • Longitudinal molecular trajectories of diffuse glioma in adults

    Floris P. Barthel;Kevin C. Johnson;Frederick S. Varn;Anzhela D. Moskalik

  • Regulation of Akt/PKB Activity, Cellular Growth, and Apoptosis in Prostate Carcinoma Cells by MMAC/PTEN

    Michael A. Davies;Dimpy Koul;Haninder Dhesi;Russell Berman

Frequent Co-Authors

Mark R. Gilbert
Mark R. Gilbert National Institutes of Health
Michael D. Prados
Michael D. Prados University of California, San Francisco
Patrick Y. Wen
Patrick Y. Wen Harvard University
Kenneth R. Hess
Kenneth R. Hess The University of Texas MD Anderson Cancer Center
Timothy F. Cloughesy
Timothy F. Cloughesy University of California, Los Angeles
Victor A. Levin
Victor A. Levin The University of Texas MD Anderson Cancer Center
Susan M. Chang
Susan M. Chang University of California, San Francisco
Minesh P. Mehta
Minesh P. Mehta University of Maryland, Baltimore
Lisa M. DeAngelis
Lisa M. DeAngelis Memorial Sloan Kettering Cancer Center
Raymond Sawaya
Raymond Sawaya The University of Texas MD Anderson Cancer Center

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