World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
62
Citations
14496
World Ranking
2970
National Ranking
1297

Overview

Donald C. Rio is affiliated with the University of California, Berkeley in the United States. Their research primarily lies at the intersection of Biochemistry, Genetics, and Molecular Biology, with a total of 28 publications in these fields. Medicine is another key domain of their work, represented in 11 publications.

The scientist's subfields of study include Molecular Biology, Neurology, Genetics, Plant Science, and Cancer Research. These subfields cover various aspects of cellular and molecular mechanisms, with Molecular Biology featuring most prominently across 27 publications. Neurology and Genetics are also significant, with contributions to the understanding of neurological and genetic processes.

Donald C. Rio's main topics of interest cover diverse aspects of RNA and genetic research. These include:

  • RNA Research and Splicing
  • CRISPR and Genetic Engineering
  • Amyotrophic Lateral Sclerosis Research
  • Neurogenetic and Muscular Disorders Research
  • RNA regulation and disease
  • Advanced biosensing and bioanalysis techniques
  • RNA modifications and cancer

Their recent publications reflect active engagement in these topics. Selected papers include:

  • "Highly efficient generation of isogenic pluripotent stem cell models using prime editing," 2022, eLife
  • "Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains," 2020, Genome Research
  • "Mechanism and regulation of P element transposition," 2020, Open Biology
  • "A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks," 2024, Genes & Development
  • "Splicing accuracy varies across human introns, tissues and age," 2023, bioRxiv (Cold Spring Harbor Laboratory)

BioRxiv (Cold Spring Harbor Laboratory) is one of the frequent publication venues for Donald C. Rio, with 8 publications appearing there. Other venues include Zenodo (CERN European Organization for Nuclear Research), eLife, Genome Research, and Open Biology.

Collaboration is a notable aspect of their scientific activity. Frequent co-authors include Oriol Busquets, Khaja Mohieddin Syed, Dirk Hockemeyer, Frank Soldner, and Hanqin Li. These collaborators have coauthored at least nine to ten papers each with Rio, indicating ongoing partnerships in diverse research projects.

Best Publications

  • Purification of RNA using TRIzol (TRI reagent).

    Donald C. Rio;Manuel Ares;Gregory J. Hannon;Timothy W. Nilsen

  • Mechanisms and Regulation of Alternative Pre-mRNA Splicing

    Yeon Lee;Donald C. Rio

  • Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing

    Frank A. Laski;Donald C. Rio;Gerald M. Rubin

  • Identification and immunochemical analysis of biologically active drosophila P element transposase

    Donald C. Rio;Frank A. Laski;Gerald M. Rubin

  • Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage.

    Michael H. Brodsky;Brian T. Weinert;Garson Tsang;Garson Tsang;Yikang S. Rong

  • SV40 gene expression is modulated by the cooperative binding of T antigen to DNA

    Richard M. Myers;Donald C. Rio;Alan K. Robbins;Robert Tjian

  • Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen.

    Donald Rio;Alan Robbins;Richard Myers;Robert Tjian

  • The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

    Eun Joo Song;Shannon L. Werner;Jakob Neubauer;Frank Stegmeier;Frank Stegmeier

  • Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome.

    Shalini Sharma;Lori A Kohlstaedt;Andrey Damianov;Donald C Rio

  • Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes.

    Richard E. Green;Benjamin P. Lewis;Benjamin P. Lewis;R. Tyler Hillman;Marco Blanchette

  • P element transposition in vitro proceeds by a cut-and-paste mechanism and uses GTP as a cofactor

    Paul D. Kaufman;Donald C. Rio

  • Biochemistry and regulation of pre-mRNA splicing

    Melissa D Adams;David Z Rudner;Donald C Rio

  • Regulated splicing of the Drosophila P transposable element third intron in vitro: somatic repression.

    Christian W. Siebel;Donald C. Rio

  • The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.

    Christian W. Siebel;Lucille D. Fresco;Donald C. Rio

  • Drosophila P element transposase recognizes internal P element DNA sequences.

    Paul D. Kaufman;Rhonda F. Doll;Donald C. Rio

  • Drosophila IRBP/Ku p70 corresponds to the mutagen-sensitive mus309 gene and is involved in P-element excision in vivo.

    Eileen L. Beall;Donald C. Rio

  • SV40 T antigen binding site mutations that affect autoregulation.

    Donald C. Rio;Robert Tjian

  • Drosophila P-element transposase is a novel site-specific endonuclease

    Eileen L. Beall;Donald C. Rio

  • Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing.

    C W Siebel;A Admon;D C Rio

  • Cis-acting DNA sequence requirements for P-element transposition

    Mary C. Mullins;Donald C. Rio;Gerald M. Rubin

Frequent Co-Authors

David Z. Rudner
David Z. Rudner Harvard University
Richard E. Green
Richard E. Green University of California, Santa Cruz
Steven E. Brenner
Steven E. Brenner University of California, Berkeley
Gerald M. Rubin
Gerald M. Rubin Howard Hughes Medical Institute
Robert Tjian
Robert Tjian University of California, Berkeley
David E. Wemmer
David E. Wemmer University of California, Berkeley
Michael Rosbash
Michael Rosbash Brandeis University
Eva Nogales
Eva Nogales University of California, Berkeley
Carlos Bustamante
Carlos Bustamante Stanford University
Stephen J. Elledge
Stephen J. Elledge Harvard University

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