World's Best Scientists 2026 revealed!
Stephen J. Elledge

Stephen J. Elledge

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Best Scientists
2025
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Genetics
USA
2026

D-Index & Metrics

Best Scientists

D-Index
186
Citations
161097
World Ranking
484
National Ranking
317

Genetics

D-Index
186
Citations
160503
World Ranking
41
National Ranking
25

Molecular Biology

D-Index
186
Citations
160503
World Ranking
30
National Ranking
21

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2017 - Breakthrough Prize in Life Sciences for elucidating how eukaryotic cells sense and respond to damage in their DNA and providing insights into the development and treatment of cancer.
  • 2017 - Gruber Prize in Genetics
  • 2015 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2015 - Fellow of the American Academy of Microbiology Genetics and Molecular Biology
  • 2013 - Canada Gairdner International Award
  • 2006 - Member of the National Academy of Medicine (NAM)
  • 2005 - Genetics Society of America Medal
  • 2003 - Member of the National Academy of Sciences
  • 2003 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center
  • 2003 - Fellow of the American Academy of Arts and Sciences

Overview

Stephen J. Elledge is affiliated with Harvard University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine. The subfields predominantly covered include Molecular Biology, Immunology, Oncology, Infectious Diseases, and Radiology, Nuclear Medicine and Imaging.

The scientist's research topics focus on areas such as ubiquitin and proteasome pathways, protein degradation and inhibitors, immunotherapy and immune responses, monoclonal and polyclonal antibodies research, vaccines and immunoinformatics approaches, CAR-T cell therapy research, and T-cell and B-cell immunology.

Frequent coauthors collaborating with Stephen J. Elledge include:

  • Richard T. Timms
  • Yumei Leng
  • Tomasz Kula
  • Mamie Z. Li
  • Christopher Nardone

They have published in multiple scientific venues, often appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Nature Communications
  • Science
  • Proceedings of the National Academy of Sciences

Recent notable publications include:

  • "Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis," 2022, Science
  • "Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity," 2020, Science
  • "The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning," 2020, Proceedings of the National Academy of Sciences
  • "The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation," 2021, Science
  • "Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction," 2021, Science

The scientist has been recognized with several awards and honors, including:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2018
  • Gruber Prize in Genetics, 2017
  • Breakthrough Prize in Life Sciences, 2017, for elucidating how eukaryotic cells sense and respond to DNA damage and insights into cancer development and treatment
  • Albert Lasker Award for Basic Medical Research, 2015
  • Fellow of the American Academy of Microbiology, 2015, Genetics and Molecular Biology
  • Canada Gairdner International Award, 2013
  • Member of the National Academy of Medicine (NAM), 2006
  • Genetics Society of America Medal, 2005
  • Fellow of the American Academy of Arts and Sciences, 2003
  • Member of the National Academy of Sciences, 2003
  • Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center, 2003

Best Publications

  • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

    J. Wade Harper;Guy R. Adami;Nan Wei;Khandan Keyomarsi

  • The DNA damage response: putting checkpoints in perspective

    Bin-Bing S. Zhou;Stephen J. Elledge

  • The DNA Damage Response: Making It Safe to Play with Knives

    Alberto Ciccia;Stephen J. Elledge;Stephen J. Elledge;Stephen J. Elledge

  • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

    Shuhei Matsuoka;Bryan A. Ballif;Agata Smogorzewska;Agata Smogorzewska;E. Robert McDonald

  • Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

    Lee Zou;Stephen J. Elledge

  • Cell Cycle Checkpoints: Preventing an Identity Crisis

    Stephen J. Elledge

  • Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

    Chuxia Deng;Chuxia Deng;Pumin Zhang;J. Wade Harper;Stephen J. Elledge;Stephen J. Elledge

  • Dicer is essential for mouse development.

    Emily Bernstein;Sang Yong Kim;Michelle A Carmell;Michelle A Carmell;Elizabeth P Murchison

  • The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

    Tim Durfee;Kathleen Becherer;Phang Lang Chen;Shiou Hwei Yeh

  • Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

    Ji Luo;Nicole L. Solimini;Stephen J. Elledge

  • Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint

    Qinghua Liu;Saritha Guntuku;Xian Shu Cui;Shuhei Matsuoka

  • The DNA Damage Response: Ten Years After

    J. Wade Harper;Stephen J. Elledge;Stephen J. Elledge;Stephen J. Elledge

  • Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

    Shuhei Matsuoka;Mingxia Huang;Stephen J. Elledge

  • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

    Vjekoslav Dulić;William K. Kaufmann;William K. Kaufmann;Sandra J. Wilson;Sandra J. Wilson;Thea D. Tisty;Thea D. Tisty

  • A quantitative atlas of mitotic phosphorylation.

    Noah Dephoure;Chunshui Zhou;Judit Villén;Sean A. Beausoleil

  • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25

    Yolanda Sanchez;Calvin Wong;Calvin Wong;Richard S. Thoma;Richard S. Thoma;Ron Richman;Ron Richman

  • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

    Chang Bai;Partha Sen;Kay Hofmann;Lei Ma

  • Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

    Abraham L. Brass;Derek M. Dykxhoorn;Yair Benita;Nan Yan

  • Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

    Ning Zheng;Brenda A. Schulman;Brenda A. Schulman;Langzhou Song;Julie J. Miller

  • DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

    Atsushi Hirao;Young-Yun Kong;Shuhei Matsuoka;Andrew Wakeham

Frequent Co-Authors

J. Wade Harper
J. Wade Harper Harvard Medical School
Agata Smogorzewska
Agata Smogorzewska Rockefeller University
Thomas F. Westbrook
Thomas F. Westbrook Baylor College of Medicine
Andrew E. H. Elia
Andrew E. H. Elia Harvard University
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Steven P. Gygi
Steven P. Gygi Harvard University
Ronald W. Davis
Ronald W. Davis Stanford University
David Cortez
David Cortez Vanderbilt University
Pumin Zhang
Pumin Zhang Baylor College of Medicine
Mathew E. Sowa
Mathew E. Sowa Harvard University

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