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D-Index & Metrics

Molecular Biology

D-Index
47
Citations
15468
World Ranking
2709
National Ranking
1312

Overview

Thomas F. Westbrook is affiliated with Baylor College of Medicine in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine. Within these broader areas, the scientist has contributed extensively to subfields including Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Cell Biology, and Cancer Research.

The topics frequently addressed in Westbrook's work include RNA modifications and cancer, Epigenetics and DNA Methylation, Ubiquitin and proteasome pathways, Microtubule and mitosis dynamics, Cancer-related gene regulation, Protein Degradation and Inhibitors, and Cancer-related Molecular Pathways.

Westbrook's recent scholarly output features multiple publications across highly regarded journals. Selected papers include:

  • Energy-stress-mediated AMPK activation inhibits ferroptosis (2020) published in Nature Cell Biology
  • Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy (2020) published in Cell
  • Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer (2021) published in Cell
  • Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer (2021) published in Molecular Cell
  • ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma (2021) published in Cancer Discovery

Frequent coauthors collaborating with Westbrook include Siddhartha Tyagi, Wesley L. Cai, Don X. Nguyen, Jitendra K. Meena, and Elizabeth A. Bowling. These partnerships have contributed to multiple projects and publications in cancer biology and molecular research.

The scientist has published frequently in major venues such as Cell, Cancer Discovery, Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), and Nature Cell Biology. These outlets reflect the interdisciplinary nature and high impact orientation of the research.

Best Publications

  • A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

    Ji Luo;Michael J. Emanuele;Danan Li;Chad J. Creighton

  • A resource for large-scale RNA-interference-based screens in mammals

    Patrick J. Paddison;Jose M. Silva;Douglas S. Conklin;Douglas S. Conklin;Mike Schlabach;Mike Schlabach

  • Energy-stress-mediated AMPK activation inhibits ferroptosis.

    Hyemin Lee;Fereshteh Zandkarimi;Yilei Zhang;Jitendra Kumar Meena

  • Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

    David J. Clark;Saravana M. Dhanasekaran;Francesca Petralia;Jianbo Pan

  • The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

    Kristen L. Meerbrey;Guang Hu;Jessica D. Kessler;Kevin Roarty

  • A Genetic Screen for Candidate Tumor Suppressors Identifies REST

    Thomas F. Westbrook;Eric S. Martin;Michael R. Schlabach;Yumei Leng

  • A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

    Yiqun Zhang;Patrick Kwok-Shing Ng;Melanie Kucherlapati;Fengju Chen

  • The spliceosome is a therapeutic vulnerability in MYC-driven cancer

    Tiffany Y.T. Hsu;Lukas M. Simon;Nicholas J. Neill;Richard Marcotte

  • A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.

    Jessica D. Kessler;Kristopher T. Kahle;Kristopher T. Kahle;Tingting Sun;Kristen L. Meerbrey

  • Cancer Proliferation Gene Discovery Through Functional Genomics

    Michael R. Schlabach;Ji Luo;Nicole L. Solimini;Guang Hu

  • MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

    Atsushi Terunuma;Nagireddy Putluri;Prachi Mishra;Ewy A. Mathé

  • The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.

    Hai Wang;Cuijuan Yu;Xia Gao;Thomas Welte

  • Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy.

    Karsten Krug;Eric J. Jaehnig;Shankha Satpathy;Lili Blumenberg

  • An animal model of MYC-driven medulloblastoma.

    Yanxin Pei;Colin E. Moore;Jun Wang;Alok K. Tewari

  • Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

    Chen Huang;Lijun Chen;Sara R. Savage;Rodrigo Vargas Eguez

  • SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.

    Thomas F. Westbrook;Thomas F. Westbrook;Guang Hu;Xiaolu L. Ang;Peter Mulligan

  • Proteogenomic Characterization of Endometrial Carcinoma.

    Yongchao Dou;Emily A. Kawaler;Daniel Cui Zhou;Marina A. Gritsenko

  • Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.

    Ik Sun Kim;Yang Gao;Thomas Welte;Hai Wang

  • Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.

    Tingting Sun;Nicola Aceto;Kristen L. Meerbrey;Jessica D. Kessler

  • Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.

    Rhamy Zeid;Matthew A. Lawlor;Evon Poon;Jaime M. Reyes

Frequent Co-Authors

Stephen J. Elledge
Stephen J. Elledge Harvard University
Chad A. Shaw
Chad A. Shaw Baylor College of Medicine
Rachel Schiff
Rachel Schiff Baylor College of Medicine
Chad J. Creighton
Chad J. Creighton Baylor College of Medicine
Jeffrey M. Rosen
Jeffrey M. Rosen Baylor College of Medicine
Juan Botas
Juan Botas Baylor College of Medicine
Michael T. Lewis
Michael T. Lewis Baylor College of Medicine
Susan G. Hilsenbeck
Susan G. Hilsenbeck Baylor College of Medicine
C. Kent Osborne
C. Kent Osborne Baylor College of Medicine
Maciej Wiznerowicz
Maciej Wiznerowicz Poznan University of Medical Sciences

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