World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
15223
World Ranking
13632
National Ranking
5784

Overview

Michael T. Lewis is affiliated with Baylor College of Medicine in the United States. Their research focuses on multiple areas within biochemistry, genetics, molecular biology, and medicine, with an emphasis on oncology and cancer research.

The main fields of study of Michael T. Lewis include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of study extend into:

  • Molecular Biology
  • Cancer Research
  • Oncology
  • Radiology, Nuclear Medicine and Imaging
  • Biotechnology

The scientist's work explores a variety of important topics related to cancer and molecular biology, including:

  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Cancer, Hypoxia, and Metabolism
  • Cancer Research and Treatments
  • Epigenetics and DNA Methylation
  • Radiomics and Machine Learning in Medical Imaging
  • Cancer-related Molecular Pathways

Michael T. Lewis has contributed significantly to several peer-reviewed publications. Some of the recent papers include:

  • "A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology," 2022, Nature Cancer
  • "Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer," 2021, Cell
  • "PHGDH heterogeneity potentiates cancer cell dissemination and metastasis," 2022, Nature
  • "Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts," 2021, Nature Genetics
  • "Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer," 2022, Cancer Discovery

The scientist has frequently collaborated with various researchers across numerous studies. Frequent co-authors include:

  • Lacey E. Dobrolecki
  • Alana L. Welm
  • Jonathan T. Lei
  • Shunqiang Li
  • John D. Landua

Michael T. Lewis has published extensively in multiple venues, with notable frequent publications in:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Tomography
  • Cell Reports Medicine
  • Journal of Mammary Gland Biology and Neoplasia

Best Publications

  • Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

    Xiaoxian Li;Michael T. Lewis;Jian Huang;Carolina Gutierrez

  • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

    Chad J. Creighton;Xiaoxian Li;Melissa Landis;J. Michael Dixon

  • Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

    Lin Tian;Amit Goldstein;Hai Wang;Hin Ching Lo

  • Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

    David J. Clark;Saravana M. Dhanasekaran;Francesca Petralia;Jianbo Pan

  • A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

    Xiaomei Zhang;Sofie Claerhout;Aleix Prat;Lacey E. Dobrolecki

  • Proteogenomic Characterization of Endometrial Carcinoma.

    Yongchao Dou;Emily A. Kawaler;Daniel Cui Zhou;Marina A. Gritsenko

  • Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail

    Hyun Jung Kim;Beate C. Litzenburger;Xiaojiang Cui;David A. Delgado

  • Patient-derived xenograft models of breast cancer and their predictive power

    James R Whittle;Michael T Lewis;Geoffrey J Lindeman;Geoffrey J Lindeman;Geoffrey J Lindeman;Jane E Visvader;Jane E Visvader

  • Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

    Jun Hyoung Park;Sajna Vithayathil;Santosh Kumar;Pi Lin Sung;Pi Lin Sung

  • Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors

    Anne F. Schott;Melissa D. Landis;Gabriela Dontu;Kent A. Griffith

  • A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.

    D. Ron;M. Zannini;M. Lewis;R. B. Wickner

  • Patient-derived xenograft (PDX) models in basic and translational breast cancer research

    Lacey E. Dobrolecki;Susie D. Airhart;Denis G. Alferez;Samuel Aparicio

  • Parallel changes in puffing activity and patterns of protein synthesis in salivary glands of Drosophila.

    Michael Lewis;Pieter J. Helmsing;Michael Ashburner

  • Patterns of Resistance and Incomplete Response to Docetaxel by Gene Expression Profiling in Breast Cancer Patients

    Jenny C. Chang;Eric C. Wooten;Anna Tsimelzon;Susan G. Hilsenbeck

  • Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells

    Francesca De Amicis;Francesca De Amicis;Janagi Thirugnansampanthan;Yukun Cui;Jennifer Selever

  • Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

    Thomas Welte;Ik Sun Kim;Lin Tian;Xia Gao

  • Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia.

    Ricardo C. Moraes;Xiaomei Zhang;Nikesha Harrington;Jennifer Y. Fung

  • Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells

    Ann H. Klopp;Lara Lacerda;Lara Lacerda;Lara Lacerda;Anshul Gupta;Bisrat G. Debeb

  • Membrane-localized estrogen receptor α is required for normal organ development and function.

    Ali Pedram;Mahnaz Razandi;Michael Lewis;Stephen Hammes

  • Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1

    Michael T. Lewis;Sarajane Ross;Phyllis A. Strickland;Charles W. Sugnet

Frequent Co-Authors

Susan G. Hilsenbeck
Susan G. Hilsenbeck Baylor College of Medicine
Chad J. Creighton
Chad J. Creighton Baylor College of Medicine
Jenny C. Chang
Jenny C. Chang Houston Methodist
Jeffrey M. Rosen
Jeffrey M. Rosen Baylor College of Medicine
Alana L. Welm
Alana L. Welm University of Utah
Matthew J. Ellis
Matthew J. Ellis Baylor College of Medicine
Rachel Schiff
Rachel Schiff Baylor College of Medicine
C. Kent Osborne
C. Kent Osborne Baylor College of Medicine
Funda Meric-Bernstam
Funda Meric-Bernstam The University of Texas MD Anderson Cancer Center
Li Ding
Li Ding Washington University in St. Louis

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