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Sendurai A. Mani

Sendurai A. Mani

Overview

Sendurai A. Mani is affiliated with Brown University in the United States and focuses their research on biochemistry, genetics, molecular biology, and medicine. Their work primarily addresses molecular biology, oncology, cancer research, cell biology, and pulmonary and respiratory medicine.

Their main research topics include:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation
  • FOXO transcription factor regulation
  • MicroRNA in disease regulation
  • RNA modifications and cancer
  • Skin and Cellular Biology Research

Sendurai A. Mani has published multiple papers in a range of academic venues, with a concentration of work in cancer-related journals. Some frequent publication venues include:

  • Cancer Research
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • British Journal of Cancer
  • Seminars in Cancer Biology

Recent notable papers by Mani and collaborators are:

  • "Guidelines and definitions for research on epithelial-mesenchymal transition," 2020, Nature Reviews Molecular Cell Biology
  • "A proteogenomic portrait of lung squamous cell carcinoma," 2021, Cell
  • "Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing," 2021, Proceedings of the National Academy of Sciences
  • "EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures," 2020, British Journal of Cancer
  • "Mechanisms of cancer metastasis," 2022, Seminars in Cancer Biology

Collaborations play a significant role in Mani's research. Frequent co-authors include:

  • Petra den Hollander
  • Nick A. Kuburich
  • Robiya Joseph
  • Suhas Vasaikar
  • Rama Soundararajan

The research contributions span across critical areas involving cancer biology, including the study of epithelial-mesenchymal transition (EMT), cell signaling pathways, and gene regulatory networks. Mani's studies often combine molecular and genomic approaches to understand cancer metastasis and diagnostic mechanisms.

Best Publications

  • The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

    Sendurai A. Mani;Wenjun Guo;Mai Jing Liao;Elinor Ng Eaton

  • Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

    Jing Yang;Sendurai A Mani;Joana Liu Donaher;Sridhar Ramaswamy;Sridhar Ramaswamy

  • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways.

    Tamer T. Onder;Piyush B. Gupta;Piyush B. Gupta;Sendurai A. Mani;Jing Yang

  • Guidelines and definitions for research on epithelial–mesenchymal transition

    Jing Yang;Parker Antin;Geert Berx;Cédric Blanpain

  • Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

    Joseph H. Taube;Jason I. Herschkowitz;Kakajan Komurov;Alicia Y. Zhou

  • Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

    Wenjun Guo;Zuzana Keckesova;Joana Liu Donaher;Tsukasa Shibue

  • CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

    Hui Ling;Riccardo Spizzo;Yaser Atlasi;Milena Nicoloso

  • Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

    Jia Lu;Xiangcang Ye;Fan Fan;Ling Xia

  • The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies.

    Brett G. Hollier;Kurt Evans;Sendurai A. Mani

  • Exploring a New Twist on Tumor Metastasis

    Jing Yang;Sendurai A. Mani;Robert A. Weinberg

  • Epithelial-mesenchymal Transition and Cancer Stem Cells: A Dangerously Dynamic Duo in Breast Cancer Progression

    Caitlin D May;Nathalie Sphyris;Kurt W Evans;Steven J Werden

  • Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer

    Tony Blick;Honor Hugo;Edwin Widodo;Edwin Widodo;Mark Waltham

  • A proteogenomic portrait of lung squamous cell carcinoma

    Shankha Satpathy;Karsten Krug;Pierre M. Jean Beltran;Sara R. Savage

  • Epithelial‐Mesenchymal Transition‐Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells

    Venkata Lokesh Battula;Kurt William Evans;Brett George Hollier;Yuexi Shi

  • FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer

    Brett G. Hollier;Agata A. Tinnirello;Steven J. Werden;Kurt W. Evans

  • Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis

    Venkata Lokesh Battula;Yuexi Shi;Kurt W. Evans;Rui Yu Wang

  • Cell type-specific DNA methylation patterns in the human breast

    Noga Bloushtain-Qimron;Noga Bloushtain-Qimron;Jun Yao;Eric L. Snyder;Michail Shipitsin

  • Epithelial–Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer

    Antonio Giordano;Hui Gao;Simone Anfossi;Evan Cohen

  • Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.

    Mai-Jing Liao;Cheng Cheng Zhang;Beiyan Zhou;Drazen B. Zimonjic

  • Towards elucidating the connection between epithelial-mesenchymal transitions and stemness.

    Mohit Kumar Jolly;Bin Huang;Mingyang Lu;Sendurai A. Mani

Frequent Co-Authors

Jeffrey T. Chang
Jeffrey T. Chang The University of Texas Health Science Center at Houston
Herbert Levine
Herbert Levine Northeastern University
Jeffrey M. Rosen
Jeffrey M. Rosen Baylor College of Medicine
Mohit Kumar Jolly
Mohit Kumar Jolly Indian Institute of Science
Xiang Zhang
Xiang Zhang University of Hong Kong
Eric S. Lander
Eric S. Lander Broad Institute
Pulickel M. Ajayan
Pulickel M. Ajayan Rice University
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Tharangattu N. Narayanan
Tharangattu N. Narayanan Tata Institute of Fundamental Research

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