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Molecular Biology

D-Index
77
Citations
34191
World Ranking
1093
National Ranking
86

Research.com Recognitions

  • 2019 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Pathology and Forensic Medicine

Overview

Thomas Brabletz is affiliated with the University of Erlangen-Nuremberg in Germany. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in medicine. Their work covers several subfields including molecular biology, oncology, cancer research, immunology, and cell biology.

The main topics addressed in their research include:

  • Cancer Cells and Metastasis
  • Epigenetics and DNA Methylation
  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Immune cells in cancer
  • MicroRNA in disease regulation
  • Genetic factors in colorectal cancer

Among their frequent co-authors are Marc P. Stemmler, Simone Brabletz, Harald Schuhwerk, Ruthger van Roey, and Geert Berx, indicating collaborative work across various aspects of molecular and cancer biology.

Their publications appear mostly in venues with a strong focus on molecular and cellular biology. Notable publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • Cell Reports
  • International Journal of Molecular Sciences
  • Nature Reviews Molecular Cell Biology

Some of their recent papers include:

  • "Guidelines and definitions for research on epithelial-mesenchymal transition" (2020), published in Nature Reviews Molecular Cell Biology
  • "Dynamic EMT: a multi-tool for tumor progression" (2021), published in The EMBO Journal
  • "Targeting EMT in Cancer with Repurposed Metabolic Inhibitors" (2020), published in Trends in Cancer
  • "Ferroptosis in health and disease" (2024), published in Redox Biology
  • "Genome-wide cooperation of EMT transcription factor ZEB 1 with YAP and AP-1 in breast cancer" (2020), published in The EMBO Journal

Their research spans mechanistic and translational aspects of cancer biology, with particular interest in epithelial-mesenchymal transition (EMT), a process crucial to cancer metastasis and progression.

Thomas Brabletz was recognized by the German National Academy of Sciences Leopoldina in 2019 for contributions in pathology and forensic medicine.

Best Publications

  • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

    Unknown

  • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

    Ulrich Wellner;Jörg Schubert;Ulrike C Burk;Otto Schmalhofer

  • Guidelines and definitions for research on epithelial–mesenchymal transition

    Jing Yang;Parker Antin;Geert Berx;Cédric Blanpain

  • Oncogenic roles of EMT-inducing transcription factors.

    Alain Puisieux;Thomas Brabletz;Julie Caramel

  • Wnt/beta-catenin signaling in cancer stemness and malignant behavior.

    Riccardo Fodde;Thomas Brabletz

  • The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

    Angela M. Krebs;Julia Mitschke;María Lasierra Losada;Otto Schmalhofer

  • The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?

    Unknown

  • Wnt signalling induces maturation of Paneth cells in intestinal crypts

    Johan H. van Es;Philippe Jay;Alex Gregorieff;Marielle E. van Gijn

  • The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

    K Aigner;B Dampier;L Descovich;M Mikula

  • Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin

    Thomas Brabletz;Falk Hlubek;Simone Spaderna;Otto Schmalhofer

  • The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

    Simone Spaderna;Otto Schmalhofer;Mandy Wahlbuhl;Arno Dimmler

  • A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.

    Simone Spaderna;Otto Schmalhofer;Falk Hlubek;Geert Berx

  • Non-redundant functions of EMT transcription factors.

    Unknown

  • Dynamic EMT: a multi-tool for tumor progression.

  • L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers

    Nancy Gavert;Maralice Conacci-Sorrell;Daniela Gast;Annette Schneider

  • The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.

    Unknown

  • Nuclear Overexpression of the Oncoprotein β-Catenin in Colorectal Cancer is Localized Predominantly at the Invasion Front

    Thomas Brabletz;Andreas Jung;Kathrin Hermann;Klaus Günther

  • Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition

    Ulf D. Kahlert;Ulf D. Kahlert;Donata Maciaczyk;Soroush Doostkam;Brent A. Orr

  • Expression of the Invasion Factor Laminin γ2 in Colorectal Carcinomas Is Regulated by β-Catenin

    Falk Hlubek;Andreas Jung;Nicole Kotzor;Thomas Kirchner

  • Expression of L1-CAM and ADAM10 in Human Colon Cancer Cells Induces Metastasis

    Nancy Gavert;Michal Sheffer;Shani Raveh;Simone Spaderna

Frequent Co-Authors

Andreas Jung
Andreas Jung University of Zurich
Avri Ben-Ze'ev
Avri Ben-Ze'ev Weizmann Institute of Science
Werner Hohenberger
Werner Hohenberger University of Erlangen-Nuremberg
Oliver Schilling
Oliver Schilling University of Freiburg
Geert Berx
Geert Berx Ghent University
Eckhart G. Hahn
Eckhart G. Hahn University of Erlangen-Nuremberg
Alain Puisieux
Alain Puisieux Claude Bernard University Lyon 1
M. Angela Nieto
M. Angela Nieto Spanish National Research Council

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