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Gerhard Christofori

Gerhard Christofori

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
37385
World Ranking
2516
National Ranking
55

Overview

Gerhard Christofori is affiliated with the University of Basel in Switzerland. Their research spans key areas in biochemistry, genetics, molecular biology, and medicine, with focused contributions to molecular biology, oncology, cell biology, cancer research, and pathology and forensic medicine.

The main topics in Christofori's work include:

  • Cancer Cells and Metastasis
  • Hippo pathway signaling and YAP/TAZ
  • Wnt/β-catenin signaling in development and cancer
  • Cancer Genomics and Diagnostics
  • Cancer-related gene regulation
  • Ubiquitin and proteasome pathways
  • Cancer-related Molecular Pathways

Christofori has published extensively, with notable recent papers including:

  • "Guidelines and definitions for research on epithelial-mesenchymal transition," 2020, Nature Reviews Molecular Cell Biology
  • "YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis," 2021, EMBO Molecular Medicine
  • "Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression," 2021, British Journal of Cancer
  • "Distinct contributions of partial and full EMT to breast cancer malignancy," 2021, Developmental Cell
  • "USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis," 2021, Oncogenesis

The publication venues where Christofori frequently publishes include:

  • Oncogene
  • Nature Reviews Molecular Cell Biology
  • STAR Protocols
  • EMBO Molecular Medicine
  • British Journal of Cancer

Among frequent co-authors are:

  • Ravi Kiran Reddy Kalathur
  • Fengyuan Tang
  • Fabiana Lüönd
  • Meera Saxena
  • Mairene Coto-Llerena

Christofori's interdisciplinary work bridges fundamental molecular mechanisms and clinical oncology. Their research addresses diverse molecular pathways and cellular processes linked to cancer progression, resistance mechanisms, and tumor heterogeneity.

Best Publications

  • EMT, the cytoskeleton, and cancer cell invasion

    Mahmut Yilmaz;Gerhard Christofori

  • A causal role for E-cadherin in the transition from adenoma to carcinoma

    Anne-Karina Perl;Petra Wilgenbus;Ulf Dahl;Henrik Semb

  • Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

    Ugo Cavallaro;Gerhard Christofori

  • Guidelines and definitions for research on epithelial–mesenchymal transition

    Jing Yang;Parker Antin;Geert Berx;Cédric Blanpain

  • Vascular endothelial growth factor‐C‐mediated lymphangiogenesis promotes tumour metastasis

    Stefano J. Mandriota;Lotta Jussila;Michael Jeltsch;Amelia Compagni

  • New signals from the invasive front

    Gerhard Christofori

  • The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

    Gerhard Christofori;Henrik Semb

  • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

    Tuomas Tammela;Georgia Zarkada;Elisabet Wallgard;Aino Murtomäki

  • Angiopoietins in angiogenesis.

    Ernesta Fagiani;Gerhard Christofori

  • Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton

    Andreas Wicki;François Lehembre;Nikolaus Wick;Brigitte Hantusch

  • The angiogenic switch in carcinogenesis

    Vanessa Baeriswyl;Gerhard Christofori

  • Mechanisms of motility in metastasizing cells.

    Mahmut Yilmaz;Gerhard Christofori

  • EMT as the ultimate survival mechanism of cancer cells.

    Neha Tiwari;Alexander Gheldof;Marianthi Tatari;Gerhard Christofori

  • A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

    Gerhard Christofori;Paul Naik;Douglas Hanahan

  • Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe?

    Maren Diepenbruck;Gerhard Christofori

  • Sox4 is a master regulator of epithelial-mesenchymal transition by controlling ezh2 expression and epigenetic reprogramming

    Neha Tiwari;Vijay K. Tiwari;Lorenz Waldmeier;Piotr J. Balwierz

  • Antiangiogenic therapy of transgenic mice impairs de novo tumor growth

    Sareh Parangi;Michael O'Reilly;Gerhard Christofori;Gerhard Christofori;Lars Holmgren;Lars Holmgren

  • Hepatocyte growth factor induces cell scattering through MAPK/Egr‐1‐mediated upregulation of Snail

    Stefan Grotegut;Dietrich von Schweinitz;Gerhard Christofori;François Lehembre

  • Mouse models of breast cancer metastasis

    Anna Fantozzi;Gerhard Christofori

  • Molecular networks that regulate cancer metastasis.

    Daniela Spano;Chantal Heck;Pasqualino De Antonellis;Gerhard Christofori

Frequent Co-Authors

Kari Alitalo
Kari Alitalo University of Helsinki
Curzio Rüegg
Curzio Rüegg University of Fribourg
Salvatore Piscuoglio
Salvatore Piscuoglio Humanitas University
Charlotte K.Y. Ng
Charlotte K.Y. Ng Humanitas University
Herbert Levine
Herbert Levine Northeastern University
Alain Puisieux
Alain Puisieux Claude Bernard University Lyon 1
Geert Berx
Geert Berx Ghent University
Walter Keller
Walter Keller University of Basel
Erik van Nimwegen
Erik van Nimwegen University of Basel

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