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Immunology

D-Index
66
Citations
21681
World Ranking
2723
National Ranking
20

Overview

Taija Makinen is affiliated with Uppsala University in Sweden. The research focus centers primarily on medicine, with substantial contributions in biochemistry, genetics, and molecular biology. The scientist's work intersects several subfields including oncology, molecular biology, surgery, neurology, and infectious diseases.

The research topics covered by Taija Makinen involve various aspects of vascular and lymphatic biology and pathology. The main topics include:

  • Lymphatic System and Diseases
  • Vascular Malformations and Hemangiomas
  • Vascular Tumors and Angiosarcomas
  • Planarian Biology and Electrostimulation
  • Hippo pathway signaling and YAP/TAZ
  • Angiogenesis and VEGF in Cancer
  • Neonatal Respiratory Health Research

Recent papers authored by or co-authored with Taija Makinen showcase research contributions mainly in vascular biology and lymphatic diseases:

  • "Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies," 2021, published in Circulation Research
  • "Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 - implications for microvascular inflammation and hypercoagulopathy in COVID-19," 2020, published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Molecular anatomy of adult mouse leptomeninges," 2023, published in Neuron
  • "Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation," 2020, published in Nature Communications
  • "Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression," 2022, published in Journal of Clinical Investigation

Taija Makinen frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cardiovascular Research
  • Journal of Clinical Investigation
  • The Journal of Experimental Medicine
  • JCI Insight

Collaboration and co-authorship are notable aspects of Taija Makinen's research practice. Frequent co-authors include:

  • Henrik Ortsäter
  • Hans Schoofs
  • Simon Stritt
  • Inés Martínez-Corral
  • Kari Alitalo

Best Publications

  • Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

    Marc G. Achen;Michael Jeltsch;Eola Kukk;Taija Mäkinen

  • Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

    Yingdi Wang;Masanori Nakayama;Mara E. Pitulescu;Tim S. Schmidt

  • Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3

    Taija Mäkinen;Tanja Veikkola;Satu Mustjoki;Terhi Karpanen

  • Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

    Taija Mäkinen;Lotta Jussila;Tanja Veikkola;Terhi Karpanen

  • Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice

    Tanja Maaret Veikkola;Lotta Jussila;Taija Marianna Mäkinen;Terhi Hannele Kärpänen

  • Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

    Tatiana V. Petrova;Taija Mäkinen;Tomi P. Mäkelä;Janna Saarela

  • Vascular heterogeneity and specialization in development and disease.

    Michael Potente;Taija Mäkinen

  • PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature

    Taija Mäkinen;Ralf H. Adams;John Bailey;Qiang Lu

  • Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)

    Pia Ostergaard;Michael A Simpson;Fiona C Connell;Colin G Steward

  • Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma

    Hsei-Wei Wang;Matthew W B Trotter;Dimitrios Lagos;Dimitra Bourboulia

  • Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

    Eleni Bazigou;Sherry Xie;Chun Chen;Anne Weston

  • Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea

    Hajime Kubo;Renhai Cao;Ebba Bräkenhielm;Taija Mäkinen

  • Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation

    Amélie Sabine;Amélie Sabine;Yan Agalarov;Yan Agalarov;Hélène Maby-El Hajjami;Hélène Maby-El Hajjami;Muriel Jaquet;Muriel Jaquet

  • Signaling via Vascular Endothelial Growth Factor Receptors

    Tatiana V. Petrova;Taija Makinen;Kari Alitalo

  • Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites

    Johan Dixelius;Taija Mäkinen;Maria Wirzenius;Marika J. Karkkainen

  • Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1

    Taija Makinen;Birgitta Olofsson;Terhi Karpanen;Ulf Hellman

  • VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

    Tuomas Tammela;Georgia Zarkada;Harri Nurmi;Lars Jakobsson

  • Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.

    Lyn M. Wise;Tanja Veikkola;Andrew A. Mercer;Loreen J. Savory

  • Lymphatic System in Cardiovascular Medicine

    Aleksanteri Aspelund;Marius R. Robciuc;Sinem Karaman;Taija Makinen

  • Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

    Eleni Bazigou;Oliver T.A. Lyons;Alberto Smith;Graham E. Venn

  • Lymphatic endothelium: a new frontier of metastasis research.

    Marika J Karkkainen;Taija Mäkinen;Kari Alitalo

  • Nonvenous Origin of Dermal Lymphatic Vasculature

    Ines Martinez-Corral;Maria H. Ulvmar;Lukas Stanczuk;Florence Tatin

Frequent Co-Authors

Kari Alitalo
Kari Alitalo University of Helsinki
Tatiana V. Petrova
Tatiana V. Petrova University of Lausanne
Peter S. Mortimer
Peter S. Mortimer St George's, University of London
Ralf H. Adams
Ralf H. Adams Max Planck Society
Friedemann Kiefer
Friedemann Kiefer University of Münster
Christer Betsholtz
Christer Betsholtz Uppsala University
Steven A. Stacker
Steven A. Stacker Peter MacCallum Cancer Centre
Marc G. Achen
Marc G. Achen St Vincents Institute of Medical Research
Sagrario Ortega
Sagrario Ortega Spanish National Research Council
Sahar Mansour
Sahar Mansour St George's, University of London

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