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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
13964
World Ranking
16971
National Ranking
383

Overview

Sagrario Ortega is affiliated with the Spanish National Research Council in Spain. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. Within these broad fields, Ortega's subfields of study include molecular biology, oncology, cancer research, physiology, and cell biology.

Their research addresses several key topics in biomedical science, notably:

  • MicroRNA in disease regulation
  • Cancer-related molecular pathways
  • CRISPR and genetic engineering
  • Pluripotent stem cells research
  • Microtubule and mitosis dynamics
  • Lymphatic system and diseases
  • Genomics and chromatin dynamics

Ortega has published frequently in notable venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • The EMBO Journal
  • Nature Cell Biology
  • Nature Cancer

Among recent publications involving Ortega's work are:

  • Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis, 2021, Journal of Clinical Investigation
  • Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism, 2021, Nature Cancer
  • Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype, 2023, Nature Metabolism
  • A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics, 2020, Developmental Cell
  • HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer, 2020, The EMBO Journal

Their collaboration network includes frequent coauthors such as Osvaldo Graña-Castro, Javier Muñoz, Marcos Malumbres, Diego Megías, and Pierfrancesco Vargiu.

Best Publications

  • Cyclin D-dependent kinases, INK4 inhibitors and cancer.

    Sagrario Ortega;Marcos Malumbres;Mariano Barbacid

  • Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

    Sagrario Ortega;Ignacio Prieto;Junko Odajima;Alberto Martín

  • Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6

    Marcos Malumbres;Rocı́o Sotillo;David Santamarı́a;Javier Galán

  • Reprogramming in vivo produces teratomas and iPS cells with totipotency features

    María Abad;Lluc Mosteiro;Cristina Pantoja;Marta Cañamero

  • Hypotensive activity of fibroblast growth factor.

    Pedro Cuevas;Fernando Carceller;Sagrario Ortega;Mercedes Zazo

  • Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis

    Esther Latres;Marcos Malumbres;Marcos Malumbres;Rocío Sotillo;Rocío Sotillo;Javier Martín;Javier Martín

  • Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1

    Alberto Martín;Junko Odajima;Sarah L. Hunt;Pierre Dubus

  • Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

    Roco Sotillo;Pierre Dubus;Javier Martn;Ernesto de la Cueva

  • CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

    Michael Jeltsch;Sawan Kumar Jha;Denis Tvorogov;Andrey Anisimov

  • cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

    Lukas Stanczuk;Lukas Stanczuk;Ines Martinez-Corral;Ines Martinez-Corral;Maria H. Ulvmar;Yang Zhang

  • FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.

    Amélie Sabine;Esther Bovay;Cansaran Saygili Demir;Wataru Kimura

  • Cyclins and CDKS in development and cancer: lessons from genetically modified mice.

    David Santamaria;Sagrario Ortega

  • Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

    Verónica Miguel;Jessica Tituaña;J. Ignacio Herrero;Laura Herrero

  • Invasive melanoma in Cdk4-targeted mice

    Rocío Sotillo;Juan F. García;Sagrario Ortega;Javier Martín

  • A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.

    Akshay K. Ahuja;Karolina Jodkowska;Federico Teloni;Anna H. Bizard

  • Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.

    Javier Martín;Sarah L Hunt;Pierre Dubus;Rocío Sotillo

  • Mice thrive without Cdk4 and Cdk2

    Cédric Barrière;David Santamaría;Antonio Cerqueira;Javier Galán

  • Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

    David Olmeda;Daniela Cerezo-Wallis;Erica Riveiro-Falkenbach;Paula C. Pennacchi

  • Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth.

    María Angeles Abéngozar;Sergio de Frutos;Sergio Ferreiro;Joaquím Soriano

  • Cohesin component dynamics during meiotic prophase I in mammalian oocytes.

    Ignacio Prieto;Charles Tease;Nieves Pezzi;Jose M Buesa

Frequent Co-Authors

Marcos Malumbres
Marcos Malumbres Instituto de Salud Carlos III
Mariano Barbacid
Mariano Barbacid Spanish National Cancer Research Centre
Pierre Dubus
Pierre Dubus University of Bordeaux
Manuel Serrano
Manuel Serrano Institució Catalana de Recerca i Estudis Avançats
Javier Martín
Javier Martín Spanish National Research Council
Maria A. Blasco
Maria A. Blasco Spanish National Cancer Research Centre
Taija Makinen
Taija Makinen Jenny ja Antti Wihurin Rahasto
Babak J. Mehrara
Babak J. Mehrara Memorial Sloan Kettering Cancer Center
Oscar Fernandez-Capetillo
Oscar Fernandez-Capetillo Spanish National Cancer Research Centre
Susan J. Clark
Susan J. Clark Garvan Institute of Medical Research

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