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Biology and Biochemistry
Spain
2026
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Biology and Biochemistry
Germany
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
130
Citations
79485
World Ranking
396
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Spain Leader Award
  • 2025 - Research.com Biology and Biochemistry in Spain Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Mariano Barbacid is affiliated with the Spanish National Cancer Research Centre in Spain. Their research focuses primarily on biochemistry, genetics, and molecular biology, with a substantial body of work in medicine. The scientist's main subfields span molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and immunology.

The research topics covered by Mariano Barbacid include melanoma and MAPK pathways, protein kinase regulation and GTPase signaling, lung cancer treatments and mutations, cancer-related molecular pathways, protein tyrosine phosphatases, ubiquitin and proteasome pathways, and cancer genomics and diagnostics.

Frequent coauthors collaborating with Mariano Barbacid are:

  • Carmen Guerra
  • Matthias Drosten
  • Mónica Musteanu
  • Carmen G. Lechuga
  • Eduardo Caleiras

The scientist regularly publishes in several renowned venues. The most frequent publication outlets include:

  • Cancer Research
  • Proceedings of the National Academy of Sciences
  • Pancreatology
  • Molecular Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)

Some representative recent papers authored or coauthored by Mariano Barbacid are:

  • "Targeting the MAPK Pathway in KRAS-Driven Tumors," 2020, Cancer Cell
  • "Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma," 2020, JCI Insight
  • "Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation," 2022, Molecular Cell
  • "Targeting KRAS mutant lung cancer: light at the end of the tunnel," 2021, Molecular Oncology
  • "Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas," 2023, Journal of Clinical Investigation

Best Publications

  • Cell cycle, CDKs and cancer: a changing paradigm

    Marcos Malumbres;Mariano Barbacid

  • RAS oncogenes: the first 30 years

    Marcos Malumbres;Mariano Barbacid

  • Tumour biology: Senescence in premalignant tumours

    Manuel Collado;Jesús Gil;Alejo Efeyan;Carmen Guerra

  • To cycle or not to cycle: a critical decision in cancer.

    Marcos Malumbres;Mariano Barbacid

  • A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

    E. Premkumar Reddy;Roberta K. Reynolds;Eugenio Santos;Mariano Barbacid

  • The trk proto-oncogene encodes a receptor for nerve growth factor.

    Rüdiger Klein;Shugian Jing;Venkata Nanduri;Edward O'Rourke

  • The Trk family of neurotrophin receptors.

    Mariano Barbacid

  • Mammalian cyclin-dependent kinases

    Marcos Malumbres;Mariano Barbacid

  • Renal agenesis and the absence of enteric neurons in mice lacking GDNF

    Marina P. Sánchez;Inmaculada Silos-Santiago;Jonas Frisén;Bin He

  • trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.

    Fabienne Lamballe;Rüdiger Klein;Mariano Barbacid

  • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.

    Carmen Guerra;Alberto J. Schuhmacher;Marta Cañamero;Paul J. Grippo

  • Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

    Richard J. Smeyne;Rüdiger Klein;Andreas Schnapp;Linda K. Long

  • The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

    Rüdiger Klein;Venkata Nanduri;Shuqian Jing;Fabienne Lamballe

  • Cdk1 is sufficient to drive the mammalian cell cycle

    David Santamaría;Cédric Barrière;Cédric Barrière;Antonio Cerqueira;Sarah Hunt

  • Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

    Z Songyang;S E Shoelson;J McGlade;P Olivier

  • A Pericyte Origin of Spinal Cord Scar Tissue

    Christian Göritz;David O. Dias;Nikolay Tomilin;Mariano Barbacid

  • Cyclin D-dependent kinases, INK4 inhibitors and cancer.

    Sagrario Ortega;Marcos Malumbres;Mariano Barbacid

  • Direct mutagenesis of Ha- ras -1 oncogenes by N -nitroso- N -methylurea during initiation of mammary carcinogenesis in rats

    Helmut Zarbl;Saraswati Sukumar;Anne V. Arthur;Dionisio Martin-Zanca

  • A Human Oncogene Formed by the Fusion of Truncated Tropomyosin and Protein Tyrosine Kinase Sequences

    Dionisio Martin-Zanca;Stephen H. Hughes;Mariano Barbacid

  • Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

    Sagrario Ortega;Ignacio Prieto;Junko Odajima;Alberto Martín

Frequent Co-Authors

Marcos Malumbres
Marcos Malumbres Instituto de Salud Carlos III
Stuart A. Aaronson
Stuart A. Aaronson Icahn School of Medicine at Mount Sinai
Sagrario Ortega
Sagrario Ortega Spanish National Research Council
Pierre Dubus
Pierre Dubus University of Bordeaux
Xosé R. Bustelo
Xosé R. Bustelo University of Salamanca
Rüdiger Klein
Rüdiger Klein Max Planck Society
Christian Trautwein
Christian Trautwein RWTH Aachen University
Piotr Sicinski
Piotr Sicinski Harvard University
Saraswati Sukumar
Saraswati Sukumar Johns Hopkins University School of Medicine
Richard J. Smeyne
Richard J. Smeyne Thomas Jefferson University

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