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Best Scientists
2025
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Genetics and Molecular Biology
Canada
2024

D-Index & Metrics

Best Scientists

D-Index
183
Citations
124350
World Ranking
551
National Ranking
13

Molecular Biology

D-Index
182
Citations
124475
World Ranking
32
National Ranking
3

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2024 - Research.com Genetics and Molecular Biology in Canada Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Canada Leader Award
  • 2023 - Research.com Molecular Biology in Canada Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Canada Leader Award
  • 2004 - Louisa Gross Horwitz Prize, Columbia University
  • 2004 - Member of the National Academy of Sciences

Overview

Tony Pawson was affiliated with the University of Toronto in Canada and contributed to multiple areas in biochemistry, genetics, and molecular biology, with emphasis also in medicine. Their research covered subfields including molecular biology, immunology and allergy, cell biology, nephrology, and biotechnology.

The studies led or co-authored by Pawson addressed a range of scientific topics, primarily centered on cell adhesion molecules research, protein kinase regulation and GTPase signaling, cellular mechanics and interactions, as well as renal diseases, glomerulopathies, and related cancers. Cancer research and treatments were another significant aspect of their work.

They published in several well-regarded scientific venues, including:

  • Nature Cell Biology
  • Journal of Cell Science
  • Nature

Among the recent papers associated with Pawson were:

  • Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions (2020, Nature Cell Biology)
  • Multivalent nephrin-Nck interactions define a threshold for clustering and tyrosine-dependent nephrin endocytosis (2020, Journal of Cell Science)
  • Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring (2021, Nature)

Pawson frequently collaborated with other researchers such as Paul Markus Müller, Juliane Rademacher, Richard D. Bagshaw, Celina Wortmann, and Carolin Barth.

They received recognition in the form of awards including becoming a Member of the National Academy of Sciences in 2004 and being awarded the Louisa Gross Horwitz Prize from Columbia University in the same year.

Best Publications

  • Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

    Yuen Ho;Albrecht Gruhler;Adrian Heilbut;Gary D Bader;Gary D Bader

  • Protein modules and signalling networks

    Tony Pawson

  • SH2 domains recognize specific phosphopeptide sequences

    Songyang Zhou;Songyang Zhou;Steven E. Shoelson;Manas Chaudhuri;Gerald Gish

  • Signaling Through Scaffold, Anchoring, and Adaptor Proteins

    Tony Pawson;John D. Scott

  • Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation

    Neil A. Farrow;Ranjith Muhandiram;Alex U. Singer;Steven M. Pascal

  • SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

    CA Koch;D Anderson;MF Moran;C Ellis

  • The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

    Dattatreya Mellacheruvu;Zachary Wright;Amber L. Couzens;Jean Philippe Lambert

  • Assembly of cell regulatory systems through protein interaction domains.

    Tony Pawson;Tony Pawson;Piers Nash;Piers Nash

  • Histone recognition and large-scale structural analysis of the human bromodomain family.

    Panagis Filippakopoulos;Sarah Picaud;Maria Mangos;Tracy Keates

  • A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

    Giuliana Pelicci;Luisa Lanfrancone;Francesco Grignani;Jane McGlade

  • Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

    Timothy J. Nott;Timothy J. Nott;Evangelia Petsalaki;Patrick Farber;Dylan Jervis

  • BIND: the Biomolecular Interaction Network Database

    Gary D. Bader;Doron Betel;Christopher W. V. Hogue

  • SH2 and SH3 domains: From structure to function

    Tony Pawson;Gerald D. Gish

  • β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB

    Eduard Batlle;Jeffrey T. Henderson;Harry Beghtel;Maaike M.W. van den Born

  • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

    Maria Rozakis-Adcock;Ross Fernley;John Wade;Tony Pawson;Tony Pawson

  • Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.

    M. Rozakis-Adcock;J. McGlade;G. Mbamalu;G. Pelicci

  • Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

    Z Songyang;S E Shoelson;J McGlade;P Olivier

  • Specificity in Signal Transduction: From Phosphotyrosine-SH2 Domain Interactions to Complex Cellular Systems

    Tony Pawson

  • The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

    Wolfgang Vogel;Gerald D Gish;Frauke Alves;Tony Pawson;Tony Pawson

  • Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

    Nicholas W Gale;Sacha J Holland;David M Valenzuela;Ann Flenniken

Frequent Co-Authors

Gerald D. Gish
Gerald D. Gish Lunenfeld-Tanenbaum Research Institute
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Frank Sicheri
Frank Sicheri Lunenfeld-Tanenbaum Research Institute
Jeffrey L. Wrana
Jeffrey L. Wrana Lunenfeld-Tanenbaum Research Institute
Mark Henkemeyer
Mark Henkemeyer The University of Texas Southwestern Medical Center
Mike Tyers
Mike Tyers University of Montreal
Susan E. Quaggin
Susan E. Quaggin Northwestern University
Alan Bernstein
Alan Bernstein Canadian Institute for Advanced Research
Lewis E. Kay
Lewis E. Kay University of Toronto
Julie D. Forman-Kay
Julie D. Forman-Kay University of Toronto

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Best Scientists Citing Tony Pawson