2006 - Fellow of the Royal Society of Canada Academy of Science
His primary scientific interests are in Cell biology, Receptor, Signal transduction, SMAD and Transforming growth factor beta. The concepts of his Cell biology study are interwoven with issues in Genetics and Ubiquitin ligase. His Receptor research is multidisciplinary, relying on both Transforming growth factor and Kinase.
His biological study spans a wide range of topics, including Cancer research, Endocytosis, Internalization and Receptor complex. His SMAD study combines topics in areas such as Cell, Embryonic stem cell, Xenopus, Nucleus and Stem cell. His Transforming growth factor beta research incorporates elements of Interleukin-21 receptor and Growth factor receptor.
Jeffrey L. Wrana spends much of his time researching Cell biology, Signal transduction, Molecular biology, Receptor and SMAD. Jeffrey L. Wrana combines subjects such as Genetics and Biochemistry with his study of Cell biology. His Signal transduction research includes elements of Cancer research, Bone morphogenetic protein and Transmembrane protein.
His study in Cancer research is interdisciplinary in nature, drawing from both Stem cell and Immunology. His Molecular biology study integrates concerns from other disciplines, such as Cell culture and Osteopontin. His Ubiquitin ligase study combines topics from a wide range of disciplines, such as Plasma protein binding and RHOA.
Jeffrey L. Wrana mainly focuses on Cell biology, Signal transduction, Hippo signaling pathway, Regeneration and Stem cell. His research integrates issues of Cellular differentiation and Induced pluripotent stem cell in his study of Cell biology. His research in Signal transduction intersects with topics in Cancer research, Cell migration, Cell growth and Cell polarity.
His study in Hippo signaling pathway is interdisciplinary in nature, drawing from both Signal transducing adaptor protein, Morphogenesis, Neurogenesis, Neuroscience and Transforming growth factor. The concepts of his Stem cell study are interwoven with issues in Cancer, Wnt signaling pathway and Homeostasis. His studies in SMAD integrate themes in fields like Bone morphogenetic protein and Effector.
His primary areas of study are Cell biology, Hippo signaling pathway, Signal transduction, Regeneration and Immunology. Jeffrey L. Wrana has included themes like Morphogenesis and Cellular differentiation in his Cell biology study. As part of the same scientific family, Jeffrey L. Wrana usually focuses on Hippo signaling pathway, concentrating on SMAD and intersecting with Pathology, TGF beta signaling pathway, Renal fibrosis and Fibrosis.
His studies deal with areas such as Transport protein, Cadherin, VE-cadherin, Adherens junction and Intracellular as well as Signal transduction. His Regeneration research includes elements of PI3K/AKT/mTOR pathway and Autocrine signalling. His Immunology research is multidisciplinary, incorporating perspectives in Growth factor receptor and Saliva.
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Mechanism of activation of the TGF-β receptor
Jeffrey L. Wrana;Liliana Attisano;Rotraud Wieser;Francesc Ventura.
TGFβ signals through a heteromeric protein kinase receptor complex
Jeffrey L. Wrana;Liliana Attisano;Juan Cárcamo;Alejandro Zentella.
Signal transduction by the TGF-beta superfamily.
Liliana Attisano;Jeffrey L. Wrana;Jeffrey L. Wrana.
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling
Hidetoshi Hayashi;Shirin Abdollah;Yubin Qiu;Jiexing Cai.
Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation
Peter Kavsak;Peter Kavsak;Richele K. Rasmussen;Carrie G. Causing;Shirin Bonni.
Molecular Cell (2000)
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.
Gianni M Di Guglielmo;Christine Le Roy;Anne F Goodfellow;Jeffrey L Wrana.
Nature Cell Biology (2003)
SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor
Tomoo Tsukazaki;Theodore A Chiang;Anne F Davison;Liliana Attisano.
Betaglycan presents ligand to the TGFβ signaling receptor
Fernando López-Casillas;Jeffrey L. Wrana;Joan Massagué.
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
Haitao Zhu;Peter Kavsak;Peter Kavsak;Shirin Abdollah;Shirin Abdollah;Jeffrey L. Wrana;Jeffrey L. Wrana.
MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
Kolja Eppert;Stephen W Scherer;Hilmi Ozcelik;Rosa Pirone.
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