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Biology and Biochemistry
Canada
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
125
Citations
73668
World Ranking
502
National Ranking
11

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2006 - Fellow of the Royal Society of Canada Academy of Science

Overview

Jeffrey L. Wrana is affiliated with the Lunenfeld-Tanenbaum Research Institute in Canada. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine. The subfields they have contributed to include Molecular Biology, Infectious Diseases, Cell Biology, Pulmonary and Respiratory Medicine, and Oncology.

Their research topics encompass:

  • SARS-CoV-2 and COVID-19 Research
  • Hippo pathway signaling and YAP/TAZ
  • SARS-CoV-2 detection and testing
  • Cancer Cells and Metastasis
  • COVID-19 Clinical Research Studies
  • Pluripotent Stem Cells Research
  • Single-cell and spatial transcriptomics

Jeffrey L. Wrana's recent publications include:

  • Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients, 2020, Science Immunology
  • Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity, 2021, Cancer Cell
  • Enteric glial cell heterogeneity regulates intestinal stem cell niches, 2021, Cell Stem Cell
  • Functional characterization of a PROTAC directed against BRAF mutant V600E, 2020, Nature Chemical Biology
  • A scalable serology solution for profiling humoral immune responses to SARS-CoV-2 infection and vaccination, 2022, Clinical & Translational Immunology

Frequent co-authors in their work include:

  • Daniel Trcka
  • Arshad Ayyaz
  • Liliana Attisano
  • Kin Chan
  • Tony Mazzulli

Their work has been published frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Stem Cell
  • Science
  • The FASEB Journal

Jeffrey L. Wrana was awarded the title of Fellow of the Royal Society of Canada in 2006 by the Academy of Science.

Best Publications

  • Mechanism of activation of the TGF-β receptor

    Jeffrey L. Wrana;Liliana Attisano;Rotraud Wieser;Francesc Ventura

  • TGFβ signals through a heteromeric protein kinase receptor complex

    Jeffrey L. Wrana;Liliana Attisano;Juan Cárcamo;Alejandro Zentella

  • Signal Transduction by the TGF-β Superfamily

    Liliana Attisano;Jeffrey L. Wrana;Jeffrey L. Wrana

  • The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

    Hidetoshi Hayashi;Shirin Abdollah;Yubin Qiu;Jiexing Cai

  • Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

    Peter Kavsak;Richele K. Rasmussen;Carrie G. Causing;Shirin Bonni

  • Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.

    Gianni M Di Guglielmo;Christine Le Roy;Anne F Goodfellow;Jeffrey L Wrana

  • Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

    Valbona Luga;Liang Zhang;Alicia M. Viloria-Petit;Abiodun A. Ogunjimi

  • SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

    Tomoo Tsukazaki;Theodore A Chiang;Anne F Davison;Liliana Attisano

  • Betaglycan presents ligand to the TGFβ signaling receptor

    Fernando López-Casillas;Jeffrey L. Wrana;Joan Massagué

  • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.

    Haitao Zhu;Peter Kavsak;Peter Kavsak;Shirin Abdollah;Shirin Abdollah;Jeffrey L. Wrana;Jeffrey L. Wrana

  • Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

    Payman Samavarchi-Tehrani;Azadeh Golipour;Azadeh Golipour;Laurent David;Hoon Ki Sung

  • MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

    Kolja Eppert;Stephen W Scherer;Hilmi Ozcelik;Rosa Pirone

  • Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity

    Barish Ozdamar;Barish Ozdamar;Rohit Bose;Rohit Bose;Miriam Barrios-Rodiles;Hong-Rui Wang

  • Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

    Christine Le Roy;Jeffrey L. Wrana

  • MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

    Marina Macías-Silva;Shirin Abdollah;Pamela A Hoodless;Rosa Pirone

  • MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

    Pamela A Hoodless;Theo Haerry;Shirin Abdollah;Mark Stapleton

  • GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

    R Wieser;J L Wrana;J Massagué

  • High-throughput mapping of a dynamic signaling network in mammalian cells.

    Miriam Barrios-Rodiles;Kevin R. Brown;Barish Ozdamar;Barish Ozdamar;Rohit Bose;Rohit Bose

  • Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

    Liliana Attisano;Juan Cárcamo;Francesc Ventura;Frances M.B. Weis

  • Dynamic modularity in protein interaction networks predicts breast cancer outcome

    Ian W Taylor;Rune Linding;David Warde-Farley;Yongmei Liu

Frequent Co-Authors

Liliana Attisano
Liliana Attisano University of Toronto
Alessandro Datti
Alessandro Datti University of Perugia
Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
Joan Massagué
Joan Massagué Memorial Sloan Kettering Cancer Center
Frank Sicheri
Frank Sicheri Lunenfeld-Tanenbaum Research Institute
Jaro Sodek
Jaro Sodek University of Toronto
Tony Pawson
Tony Pawson University of Toronto
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Laurence Pelletier
Laurence Pelletier Lunenfeld-Tanenbaum Research Institute
Benjamin J. Blencowe
Benjamin J. Blencowe University of Toronto

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