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Alessandro Datti

Alessandro Datti

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8692
World Ranking
18022
National Ranking
577

Overview

Alessandro Datti is affiliated with the University of Perugia in Italy and contributes actively to biochemistry, genetics, and molecular biology research. Their work bridges core medical sciences and intricate molecular mechanisms, focusing primarily on genetics and molecular biology with additional contributions to immunology, oncology, and plant science.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these areas, Datti's subfields of research are:

  • Molecular Biology
  • Immunology
  • Genetics
  • Oncology
  • Plant Science

Their research spans important topics such as:

  • Thyroid Cancer Diagnosis and Treatment
  • BRCA gene mutations in cancer
  • Genetic factors in colorectal cancer
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • RNA and protein synthesis mechanisms
  • Interferon and immune responses

Datti has published multiple recent papers covering diverse scientific themes. Noteworthy publications include:

  • "Sprouts and Microgreens: Trends, Opportunities, and Horizons for Novel Research," 2020, Agronomy
  • "ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway," 2020, Nature Communications
  • "The genomic and evolutionary landscapes of anaplastic thyroid carcinoma," 2024, Cell Reports
  • "Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis," 2020, EBioMedicine
  • "A drug discovery platform to identify compounds that inhibit EGFR triple mutants," 2020, Nature Chemical Biology

The frequent publication venues where Datti's work appears include:

  • Nature Communications
  • Cell Reports
  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Plant Cell Tissue and Organ Culture (PCTOC)

Collaboration is a notable part of their academic activity. Frequent coauthors feature prominently in their work and include:

  • Jenny Wang
  • Michaël Prakesch
  • Rima Al-awar
  • Stephenie D. Prokopec
  • Nicole Pinto

Best Publications

  • Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

    Payman Samavarchi-Tehrani;Azadeh Golipour;Azadeh Golipour;Laurent David;Hoon Ki Sung

  • Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Marko Škrtić;Shrivani Sriskanthadevan;Bozhena Jhas;Marinella Gebbia

  • Systematic exploration of essential yeast gene function with temperature-sensitive mutants

    Zhijian Li;Franco J. Vizeacoumar;Sondra Bahr;Jingjing Li

  • Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

    Richard Marcotte;Kevin R. Brown;Fernando Suarez;Azin Sayad

  • Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

    Yanina Eberhard;Sean P. McDermott;Xiaoming Wang;Marcela Gronda

  • Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

    Hong Han;Ulrich Braunschweig;Thomas Gonatopoulos-Pournatzis;Robert J. Weatheritt;Robert J. Weatheritt

  • Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

    Xueqing Lun;J. Connor Wells;Natalie Grinshtein;Jennifer C King

  • Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

    Eric A. Lee;Leonard Angka;Sarah-Grace Rota;Thomas Hanlon

  • Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

    Mahadeo A. Sukhai;Swayam Prabha;Rose Hurren;Angela C. Rutledge

  • The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

    Lara O'Donnell;Stephanie Panier;Stephanie Panier;Jan Wildenhain;Johnny M. Tkach

  • High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer

    Julia Izrailit;Hal K. Berman;Hal K. Berman;Alessandro Datti;Alessandro Datti;Jeffrey L. Wrana

  • The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.

    Sumaiya Sharmeen;Marko Skrtic;Mahadeo A. Sukhai;Rose Hurren

  • A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

    Jouhyun Jeon;Satra Nim;Joan Teyra;Alessandro Datti;Alessandro Datti

  • Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

    Craig D. Simpson;Imtiaz A. Mawji;Kika Anyiwe;Moyo A. Williams

  • RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

    Robert A. Jones;Tyler J. Robinson;Jeff C. Liu;Mariusz Shrestha

  • Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

    Natalie Grinshtein;Alessandro Datti;Mayumi Fujitani;David Uehling

  • Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

    Jeff C Liu;Veronique Voisin;Sharon Wang;Sharon Wang;Dong‐Yu Wang;Dong‐Yu Wang

  • A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

    Dea Shahinas;Michael Liang;Alessandro Datti;Dylan R Pillai;Dylan R Pillai

  • Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

    Franco J. Vizeacoumar;Nydia Van Dyk;Frederick S. Vizeacoumar;Vincent Cheung

  • MicroRNA Implications across Neurodevelopment and Neuropathology

    Sabata Martino;Ilaria di Girolamo;Antonio Orlacchio;Alessandro Datti

Frequent Co-Authors

Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
Jeffrey L. Wrana
Jeffrey L. Wrana Lunenfeld-Tanenbaum Research Institute
James W. Dennis
James W. Dennis Lunenfeld-Tanenbaum Research Institute
Paul C. Boutros
Paul C. Boutros University of California, Los Angeles
Jason Moffat
Jason Moffat University of Toronto
John E. Dick
John E. Dick Princess Margaret Cancer Centre
Robert A. Batey
Robert A. Batey University of Toronto
Corey Nislow
Corey Nislow University of British Columbia
Mark D. Minden
Mark D. Minden Princess Margaret Cancer Centre
Guri Giaever
Guri Giaever University of British Columbia

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