His primary areas of investigation include Reprogramming, Cell biology, Induced pluripotent stem cell, Cellular differentiation and Embryonic stem cell. He usually deals with Reprogramming and limits it to topics linked to Transcription factor and Cell. His Cell biology research includes elements of SOX2, Molecular biology and Somatic cell.
His research integrates issues of Endothelial stem cell, Stem cell transplantation for articular cartilage repair, Amniotic epithelial cells, Adult stem cell and Progenitor cell in his study of SOX2. Jose M. Polo focuses mostly in the field of Somatic cell, narrowing it down to matters related to DNA methylation and, in some cases, Endoderm and Mesoderm. His biological study spans a wide range of topics, including Epithelial–mesenchymal transition and Proteome.
Cell biology, Reprogramming, Induced pluripotent stem cell, Embryonic stem cell and Transcription factor are his primary areas of study. His biological study focuses on Stem cell. His study in the field of Progenitor cell and Haematopoiesis is also linked to topics like Population and Trophoblast.
The various areas that Jose M. Polo examines in his Reprogramming study include Nuclear reprogramming, Computational biology and Cell type. The study incorporates disciplines such as SOX2, Molecular biology, Cellular differentiation and Somatic cell in addition to Induced pluripotent stem cell. His study on Transcription factor also encompasses disciplines like
Jose M. Polo mainly investigates Cell biology, Stem cell, Induced pluripotent stem cell, Transcriptome and Reprogramming. His Cell biology study also includes
His Induced pluripotent stem cell research is multidisciplinary, relying on both Neuroscience and Blood–brain barrier. Chromatin remodeling is closely connected to Wnt signaling pathway in his research, which is encompassed under the umbrella topic of Transcriptome. His Reprogramming study incorporates themes from Blastocyst and Somatic cell.
Jose M. Polo spends much of his time researching Cell biology, Stem cell, Trophoblast, Reprogramming and Induced pluripotent stem cell. The concepts of his Cell biology study are interwoven with issues in Oxidative stress and Olfactory system. His Stem cell research is multidisciplinary, incorporating perspectives in Epidermal growth factor, Regeneration, Protein kinase B and Organoid.
His Trophoblast research spans across into fields like Epiblast, Embryogenesis, Gene mutation, Cell and Blastocyst. His work deals with themes such as Chromatin, Transcriptome and Somatic cell, which intersect with Induced pluripotent stem cell.
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Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Jose M. Polo;Susanna Liu;Maria Eugenia Figueroa;Warakorn Kulalert.
Nature Biotechnology (2010)
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
Jochen Utikal;Jose M. Polo;Matthias Stadtfeld;Nimet Maherali.
A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Jose M. Polo;Endre Anderssen;Endre Anderssen;Ryan M. Walsh;Benjamin A. Schwarz.
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice
Katrin Arnold;Abby Sarkar;Abby Sarkar;Mary Anna Yram;Mary Anna Yram;Jose M. Polo;Jose M. Polo.
Cell Stem Cell (2011)
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
Yuki Ohi;Han Qin;Chibo Hong;Laure Blouin.
Nature Cell Biology (2011)
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Eliana Mariño;James L Richards;Keiran H McLeod;Dragana Stanley.
Nature Immunology (2017)
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.
Alexandra Grubman;Alexandra Grubman;Alexandra Grubman;Gabriel Chew;John F Ouyang;Guizhi Sun;Guizhi Sun;Guizhi Sun.
Nature Neuroscience (2019)
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.
Jose M Polo;Tania Dell'Oso;Stella Maris Ranuncolo;Leandro Cerchietti.
Nature Medicine (2004)
A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.
Leandro C. Cerchietti;Alexandru F. Ghetu;Xiao-Han Zhu;Gustavo F. Da Silva.
Cancer Cell (2010)
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
Stella Maris Ranuncolo;Jose M Polo;Jamil Dierov;Michael Singer.
Nature Immunology (2007)
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