World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
57
Citations
16386
World Ranking
13602
National Ranking
378

Overview

Jose M. Polo is affiliated with Monash University in Australia and has a research portfolio centered on biochemistry, genetics, and molecular biology, with significant contributions in medicine. Their work spans various subfields, including molecular biology, immunology, infectious diseases, cancer research, and neurology.

The scientist's research interests encompass pluripotent stem cells, CRISPR and genetic engineering technologies, single-cell and spatial transcriptomics, RNA research and splicing, renal and related cancers, neuroinflammation, neurodegeneration mechanisms, and genomics and chromatin dynamics.

They have contributed to several recent publications, among which are:

  • Transcriptional signature in microglia associated with Aβ plaque phagocytosis, 2021, Nature Communications
  • Modelling human blastocysts by reprogramming fibroblasts into iBlastoids, 2021, Nature
  • Reprogramming roadmap reveals route to human induced trophoblast stem cells, 2020, Nature
  • Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution, 2022, Cell
  • Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium, 2020, Cell stem cell

Jose M. Polo frequently collaborates with several researchers, including:

  • Joseph Chen
  • Christian M. Nefzger
  • Guizhi Sun
  • Xiaodong Liu
  • Yu Sun

Their research has been published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Stem Cell Reports, Nature Cell Biology, and Nature.

Best Publications

  • Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

    Jose M. Polo;Susanna Liu;Maria Eugenia Figueroa;Warakorn Kulalert

  • Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

    Jochen Utikal;Jose M. Polo;Matthias Stadtfeld;Nimet Maherali

  • A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

    Jose M. Polo;Endre Anderssen;Endre Anderssen;Ryan M. Walsh;Benjamin A. Schwarz

  • Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice

    Katrin Arnold;Abby Sarkar;Abby Sarkar;Mary Anna Yram;Mary Anna Yram;Jose M. Polo;Jose M. Polo

  • A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.

    Alexandra Grubman;Alexandra Grubman;Alexandra Grubman;Gabriel Chew;John F Ouyang;Guizhi Sun;Guizhi Sun;Guizhi Sun

  • Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

    Eliana Mariño;James L Richards;Keiran H McLeod;Dragana Stanley

  • Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

    Yuki Ohi;Han Qin;Chibo Hong;Laure Blouin

  • Class-switch recombination occurs infrequently in germinal centers

    Jonathan A. Roco;Luka Mesin;Sebastian C. Binder;Christian Nefzger

  • Transcriptional signature in microglia associated with Aβ plaque phagocytosis.

    Alexandra Grubman;Alexandra Grubman;Alexandra Grubman;Xin Yi Choo;Gabriel Chew;John F Ouyang

  • Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

    Jose M Polo;Tania Dell'Oso;Stella Maris Ranuncolo;Leandro Cerchietti

  • A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

    Leandro C. Cerchietti;Alexandru F. Ghetu;Xiao-Han Zhu;Gustavo F. Da Silva

  • Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR

    Stella Maris Ranuncolo;Jose M Polo;Jamil Dierov;Michael Singer

  • A predictive computational framework for direct reprogramming between human cell types.

    Owen J L Rackham;Jaber Firas;Hai Fang;Matt E Oates

  • A Murine ESC-like State Facilitates Transgenesis and Homologous Recombination in Human Pluripotent Stem Cells

    Christa Buecker;Hsu Hsin Chen;Jose Maria Polo;Laurence Daheron

  • Highly Coordinated Proteome Dynamics during Reprogramming of Somatic Cells to Pluripotency

    Jenny Hansson;Mahmoud Reza Rafiee;Sonja Reiland;Jose Maria Polo

  • Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

    Xiaodong Liu;Xiaodong Liu;Xiaodong Liu;Jia Ping Tan;Jia Ping Tan;Jia Ping Tan;Jan Schröder;Jan Schröder;Jan Schröder;Asma Aberkane

  • The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL

    Weimin Ci;Jose M. Polo;Leandro Cerchietti;Rita Shaknovich

  • Genome-wide Chromatin Interactions of the Nanog Locus in Pluripotency, Differentiation, and Reprogramming

    Effie Apostolou;Francesco Ferrari;Ryan M Walsh;Ryan M Walsh;Ori Bar-Nur;Ori Bar-Nur

  • A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

    Leandro C. Cerchietti;Shao Ning Yang;Rita Shaknovich;Katerina Hatzi

  • A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

    Katerina Hatzi;Yanwen Jiang;Chuanxin Huang;Francine Garrett-Bakelman

Frequent Co-Authors

Ari Melnick
Ari Melnick Cornell University
Ryan Lister
Ryan Lister University of Western Australia
Konrad Hochedlinger
Konrad Hochedlinger Harvard University
Susan K. Nilsson
Susan K. Nilsson Commonwealth Scientific and Industrial Research Organisation
Enrico Petretto
Enrico Petretto Duke NUS Graduate Medical School
Gilbert G. Privé
Gilbert G. Privé University of Toronto
Catriona McLean
Catriona McLean The Alfred Hospital
Margaret A. Shipp
Margaret A. Shipp Harvard University
Jody J. Haigh
Jody J. Haigh University of Manitoba
Susan J. Clark
Susan J. Clark Garvan Institute of Medical Research

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