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Overview

David Ames is affiliated with the University of Melbourne in Australia and has an extensive research portfolio primarily in the field of Medicine. Their work spans various subfields including Psychiatry and Mental Health, Molecular Biology, Physiology, Cardiology and Cardiovascular Medicine, and Genetics.

The main topics of David Ames's research include:

  • Dementia and Cognitive Impairment Research
  • Alzheimer's Disease Research and Treatments
  • Functional Brain Connectivity Studies
  • Nutritional Studies and Diet
  • Genetic Associations and Epidemiology
  • Metabolomics and Mass Spectrometry Studies
  • Advanced Neuroimaging Techniques and Applications

David Ames has published numerous papers in high-profile journals, with recent notable publications including:

  • Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture, 2020, Nature Communications
  • Plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross-sectional and longitudinal study in the AIBL cohort, 2022, Alzheimer's & Dementia
  • Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease, 2021, Journal of Alzheimer's Disease Reports
  • Assessment of the DTI-ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia, 2021, Journal of Neuroimaging
  • Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease, 2020, Nature Communications

The frequent co-authors who have collaborated extensively with David Ames are:

  • Colin L. Masters
  • Ralph N. Martins
  • Victor L. Villemagne
  • Christopher C. Rowe
  • Stephanie R. Rainey-Smith

David Ames's research has been published across several respected venues, with repeated contributions to:

  • Alzheimer's & Dementia
  • Nature Communications
  • Journal of Alzheimer's Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring

In addition to journal publications, David Ames has contributed to book literature, including a publication from Cambridge University Press titled Guide to the Psychiatry of Old Age published in 2022.

Best Publications

  • Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.

    Gill Livingston;Gill Livingston;Jonathan Huntley;Andrew Sommerlad;Andrew Sommerlad;David Ames

  • Dementia prevention, intervention, and care

    Gill Livingston;Gill Livingston;Andrew Sommerlad;Vasiliki Orgeta;Sergi G Costafreda;Sergi G Costafreda

  • Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study.

    Victor L. Villemagne;Samantha Burnham;Pierrick Bourgeat;Belinda M. Brown

  • Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

    Craig W Ritchie;Ashley I Bush;Andrew J Mackinnon;Steve Macfarlane

  • The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

    Kathryn A Ellis;Ashley I Bush;David Darby;Daniela De Fazio

  • Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

    Christopher C Rowe;Kathryn A Ellis;Kathryn A Ellis;Miroslava Rimajova;Pierrick Bourgeat

  • Longitudinal Assessment of Aβ and Cognition in Aging and Alzheimer Disease

    Victor L Villemagne;Kerryn E Pike;Gaël Chételat;Kathryn A Ellis

  • Common genetic variants influence human subcortical brain structures.

    Derrek P. Hibar;Jason L. Stein;Jason L. Stein;Miguel E. Renteria;Alejandro Arias-Vasquez

  • Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

    L. Evered;L. Evered;B. Silbert;B. Silbert;D.S. Knopman;D.A. Scott;D.A. Scott

  • Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

    Lars Lannfelt;Kaj Blennow;Henrik Zetterberg;Stellan Batsman

  • The genetic architecture of the human cerebral cortex

    Katrina L. Grasby;Neda Jahanshad;Jodie N. Painter;Lucía Colodro-Conde

  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

    Gail Davies;Max Lam;Sarah E. Harris;Joey W. Trampush

  • A Randomized Placebo-Controlled Trial of Risperidone for the Treatment of Aggression, Agitation, and Psychosis of Dementia

    Henry Brodaty;David Ames;John Snowdon;Michael Woodward

  • The prevalence of anxiety in older adults: Methodological issues and a review of the literature

    Christina Bryant;Henry Jackson;David Ames

  • Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.

    Gaël Chételat;Victor L. Villemagne;Pierrick Bourgeat;Kerryn E. Pike

  • Increased risk of cognitive impairment in patients with diabetes is associated with metformin

    Eileen Moore;Eileen Moore;Alastair Mander;David Ames;Mark A. Kotowicz;Mark A. Kotowicz;Mark A. Kotowicz

  • Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

    James D. Doecke;James D. Doecke;Simon M. Laws;Simon M. Laws;Noel G. Faux;Noel G. Faux;William Wilson

  • Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

    G. Davies;N. Armstrong;J. C. Bis;J. Bressler

  • Intensity of dementia through latent variable modelling (I-DeLV) in the AIBL cohort

    Samantha Burnham;Petra Graham;Bill Wilson;David Ames

  • The amyloid precursor protein of Alzheimer's disease is released by human platelets.

    A I Bush;R N Martins;B Rumble;R Moir

Frequent Co-Authors

Ralph N. Martins
Ralph N. Martins Edith Cowan University
Christopher C. Rowe
Christopher C. Rowe University of Melbourne
Victor L. Villemagne
Victor L. Villemagne University of Pittsburgh
Kathryn A. Ellis
Kathryn A. Ellis University of Melbourne
Colin L. Masters
Colin L. Masters University of Melbourne
Olivier Salvado
Olivier Salvado Commonwealth Scientific and Industrial Research Organisation
Paul Maruff
Paul Maruff University of Melbourne
Cassandra Szoeke
Cassandra Szoeke University of Melbourne
Ashley I. Bush
Ashley I. Bush Florey Institute of Neuroscience and Mental Health
Henry Brodaty
Henry Brodaty University of New South Wales

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