World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
77
Citations
33607
World Ranking
1739
National Ranking
62

Overview

Jason Moffat is affiliated with the University of Toronto in Canada. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with 186 publications, and Medicine, with 82 publications.

The scientist's subfields of focus include Molecular Biology, Oncology, Genetics, Immunology, and Cancer Research, reflecting a broad engagement with life sciences, especially related to cancer biology and immunology.

The main topics covered in their work are:

  • CRISPR and Genetic Engineering
  • Glioma Diagnosis and Treatment
  • CAR-T cell therapy research
  • Single-cell and spatial transcriptomics
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer

Jason Moffat has contributed to research articles in several publication venues, frequently publishing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology Advances
  • Cancer Research
  • Neuro-Oncology
  • Cancer Immunology Research

The scientist has collaborated extensively with colleagues, coauthoring the most publications with Kevin R. Brown, Sheila K. Singh, Chitra Venugopal, Katherine Chan, and Chirayu Chokshi.

Recent notable papers include:

  • "High-content CRISPR screening" (2022) published in Nature Reviews Methods Primers
  • "Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy" (2021) published in Cell
  • "Functional genomic landscape of cancer-intrinsic evasion of killing by T cells" (2020) published in Nature
  • "High-content CRISPR screening" (2022) published in Nature Reviews Methods Primers
  • "The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma" (2020) published in Cell Stem Cell

Best Publications

  • CellProfiler: image analysis software for identifying and quantifying cell phenotypes

    Anne E Carpenter;Thouis R Jones;Michael R Lamprecht;Colin Clarke

  • A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

    Jason Moffat;Dorre A. Grueneberg;Xiaoping Yang;So Young Kim;So Young Kim

  • Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

    David A. Guertin;David A. Guertin;Deanna M. Stevens;Carson C. Thoreen;Aurora A. Burds

  • High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

    Traver Hart;Megha Chandrashekhar;Michael Aregger;Zachary Steinhart

  • MECHANISM OF INHIBITION OF PROTEIN-TYROSINE PHOSPHATASES BY VANADATE AND PERVANADATE

    Gregory Huyer;Susana Liu;John Kelly;Jason Moffat

  • Exploration of essential gene functions via titratable promoter alleles

    Sanie Mnaimneh;Armaity P Davierwala;Jennifer Haynes;Jason Moffat

  • Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Marko Škrtić;Shrivani Sriskanthadevan;Bozhena Jhas;Marinella Gebbia

  • The Shieldin complex mediates 53BP1-dependent DNA repair

    Sylvie M. Noordermeer;Sylvie M. Noordermeer;Salomé Adam;Dheva Setiaputra;Marco Barazas

  • Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

    Johnny M. Tkach;Askar Yimit;Anna Y. Lee;Michael Riffle

  • A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

    Gagan D. Gupta;Étienne Coyaud;João Gonçalves;Bahareh A. Mojarad

  • Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

    Traver Hart;Amy Hin Yan Tong;Katie Chan;Jolanda Van Leeuwen

  • Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

    Thouis R. Jones;Thouis R. Jones;Anne E. Carpenter;Anne E. Carpenter;Michael R. Lamprecht;Jason Moffat

  • Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.

    Richard Marcotte;Azin Sayad;Kevin R. Brown;Felix Sanchez-Garcia

  • CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

    Michal Zimmermann;Olga Murina;Martin A. M. Reijns;Angelo Agathanggelou

  • Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

    Traver Hart;Kevin R Brown;Fabrice Sircoulomb;Robert Rottapel;Robert Rottapel;Robert Rottapel

  • MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

    Hong Han;Manuel Irimia;P. Joel Ross;Hoon Ki Sung

  • Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

    Richard Marcotte;Kevin R. Brown;Fernando Suarez;Azin Sayad

  • Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma

    M.A. Qazi;P. Vora;C. Venugopal;S.S. Sidhu

  • Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

    Sumaiyah K. Rehman;Jennifer Haynes;Evelyne Collignon;Kevin R. Brown

  • Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Alicia Cole;Zezhou Wang;Etienne Coyaud;Veronique Voisin

Frequent Co-Authors

Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
Brenda J. Andrews
Brenda J. Andrews University of Toronto
Stephane Angers
Stephane Angers University of Toronto
Amy Hin Yan Tong
Amy Hin Yan Tong University of Toronto
Daniel Durocher
Daniel Durocher Lunenfeld-Tanenbaum Research Institute
Charles Boone
Charles Boone University of Toronto
Alessandro Datti
Alessandro Datti University of Perugia
Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
David L. Kaplan
David L. Kaplan Tufts University

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