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Genetics

D-Index
102
Citations
77757
World Ranking
692
National Ranking
352

Overview

David E. Root is a researcher affiliated with MIT in the United States with a focus on the intersection of biochemistry, genetics, molecular biology, and medicine. Their work concentrates on molecular biology, genetics, cancer research, oncology, and pulmonary and respiratory medicine.

The scientific topics covered extensively in their publications include CRISPR and genetic engineering, protein degradation and inhibitors, cancer genomics and diagnostics, ubiquitin and proteasome pathways, chromatin remodeling and cancer, glioma diagnosis and treatment, and epigenetics and DNA methylation.

David E. Root has been published prominently in several journals. The most frequent venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Nature Communications
  • Cancer Discovery

Examples of their recent scientific papers are:

  • Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects, 2021, Genome Biology
  • In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer, 2022, Nature Immunology
  • Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer, 2020, Clinical Cancer Research
  • Noncanonical open reading frames encode functional proteins essential for cancer cell survival, 2021, Nature Biotechnology
  • Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers, 2021, Nature Genetics

Frequent collaborators with David E. Root include:

  • Federica Piccioni
  • William C. Hahn
  • Amy Goodale
  • Nicole S. Persky
  • Francisca Vázquez

Best Publications

  • Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

    Ophir Shalem;Ophir Shalem;Neville E Sanjana;Neville E Sanjana;Ella Hartenian;Xi-Shun Shi

  • Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

    John G Doench;Nicolo Fusi;Meagan Sullender;Mudra Hegde

  • A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

    Aravind Subramanian;Rajiv Narayan;Steven M. Corsello;Steven M. Corsello;David D. Peck

  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

    David A. Barbie;Pablo Tamayo;Jesse S. Boehm;So Young Kim

  • Defining a Cancer Dependency Map

    Aviad Tsherniak;Francisca Vazquez;Francisca Vazquez;Phil G. Montgomery;Barbara A. Weir;Barbara A. Weir

  • lincRNAs act in the circuitry controlling pluripotency and differentiation

    Mitchell Guttman;Julie Donaghey;Bryce W. Carey;Manuel Garber

  • A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

    Jason Moffat;Dorre A. Grueneberg;Xiaoping Yang;So Young Kim;So Young Kim

  • Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

    Robin M Meyers;Jordan G Bryan;James M McFarland;Barbara A Weir

  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Cory M Johannessen;Jesse S. Boehm;So Young Kim;Sapana R. Thomas;Sapana R. Thomas

  • Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

    John G Doench;Ella Hartenian;Daniel B Graham;Zuzana Tothova

  • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

    Richard Possemato;Kevin M. Marks;Yoav D. Shaul;Michael E. Pacold

  • In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

    Robert T. Manguso;Robert T. Manguso;Hans W. Pope;Hans W. Pope;Margaret D. Zimmer;Margaret D. Zimmer;Flavian D. Brown

  • Identification of RPS14 as a 5q - syndrome gene by RNA interference screen

    Benjamin L. Ebert;Jennifer Pretz;Jocelyn Bosco;Cindy Y. Chang

  • The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

    Lauren L.C. Marotta;Vanessa Almendro;Vanessa Almendro;Andriy Marusyk;Michail Shipitsin

  • β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

    Joseph Rosenbluh;Deepak Nijhawan;Deepak Nijhawan;Deepak Nijhawan;Andrew G. Cox;Andrew G. Cox;Xingnan Li

  • Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

    Jordi Barretina;Barry S Taylor;Barry S Taylor;Shantanu Banerji;Shantanu Banerji;Alexis H Ramos;Alexis H Ramos

  • CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

    Ron Firestein;Adam Bass;So Young Kim;Ian Frederick Dunn

  • KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

    Diane D. Shao;Wen Xue;Elsa B. Krall;Elsa B. Krall;Arjun Bhutkar

  • Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Kendall R. Sanson;Ruth E. Hanna;Mudra Hegde;Katherine F. Donovan

  • (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

    Julie Aurore Losman;Ryan E. Looper;Peppi Koivunen;Sungwoo Lee

Frequent Co-Authors

William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Todd R. Golub
Todd R. Golub Harvard University
Jesse S. Boehm
Jesse S. Boehm Broad Institute
Francisca Vazquez
Francisca Vazquez Broad Institute
John G. Doench
John G. Doench Broad Institute
Aviad Tsherniak
Aviad Tsherniak Broad Institute
Levi A. Garraway
Levi A. Garraway Roche (United States)
Barbara A. Weir
Barbara A. Weir Janssen (United States)
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University

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