World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
102
Citations
77757
World Ranking
692
National Ranking
352

David E. Root publication distribution in Genetics in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Genetics in 2026. The highlighted bar marks where David E. Root sits on this spectrum.

45–54 publications: 6 scientists 55–64 publications: 10 scientists 65–74 publications: 35 scientists 75–84 publications: 84 scientists 85–94 publications: 102 scientists 95–104 publications: 151 scientists 105–114 publications: 175 scientists 115–124 publications: 203 scientists 125–134 publications: 217 scientists 135–144 publications: 205 scientists 145–154 publications: 193 scientists 155–164 publications: 188 scientists 165–174 publications: 170 scientists 175–184 publications: 178 scientists 185–194 publications: 164 scientists 195–204 publications: 173 scientists 205–214 publications: 159 scientists 215–224 publications: 134 scientists 225–234 publications: 143 scientists 235–244 publications: 105 scientists 245–254 publications: 114 scientists 255–264 publications: 92 scientists 265–274 publications: 88 scientists 275–284 publications: 87 scientists 285–294 publications: 80 scientists 295–304 publications: 62 scientists 305–314 publications: 75 scientists 315–324 publications: 67 scientists 325–334 publications: 60 scientists 335–344 publications: 52 scientists 345–354 publications: 40 scientists 355–364 publications: 48 scientists 365–374 publications: 47 scientists 375–384 publications: 46 scientists 385–394 publications: 31 scientists 395–404 publications: 27 scientists 405–414 publications: 40 scientists 415–424 publications: 30 scientists 425–434 publications: 43 scientists 435–444 publications: 29 scientists 445–454 publications: 14 scientists 455–464 publications: 28 scientists 465–474 publications: 21 scientists 475–484 publications: 21 scientists 485–494 publications: 22 scientists 495–504 publications: 17 scientists 505–514 publications: 12 scientists 515–524 publications: 11 scientists 525–534 publications: 8 scientists 535–544 publications: 8 scientists 545–554 publications: 14 scientists 555–564 publications: 4 scientists 565–574 publications: 11 scientists 575–584 publications: 5 scientists 585–594 publications: 11 scientists 595–604 publications: 12 scientists 605–614 publications: 7 scientists 615–624 publications: 6 scientists 625–634 publications: 10 scientists 635–644 publications: 9 scientists 645–654 publications: 10 scientists 655–664 publications: 6 scientists 665–674 publications: 6 scientists 675–684 publications: 6 scientists 685–694 publications: 4 scientists 695–702 publications: 6 scientists 703+ publications: 100 scientists
45 publications 703+

This scientist: 265 publications — 69th percentile

69% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 703 publications or more.

David E. Root D-index placement in Genetics in 2026

The chart shows the D-index (discipline H-index) distribution of Genetics scientists ranked by Research.com in 2026. The highlighted bar marks where David E. Root sits on this spectrum.

40–41 D-Index: 24 scientists 42–43 D-Index: 52 scientists 44–45 D-Index: 84 scientists 46–47 D-Index: 112 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 141 scientists 52–53 D-Index: 143 scientists 54–55 D-Index: 145 scientists 56–57 D-Index: 179 scientists 58–59 D-Index: 162 scientists 60–61 D-Index: 175 scientists 62–63 D-Index: 191 scientists 64–65 D-Index: 172 scientists 66–67 D-Index: 184 scientists 68–69 D-Index: 164 scientists 70–71 D-Index: 158 scientists 72–73 D-Index: 150 scientists 74–75 D-Index: 136 scientists 76–77 D-Index: 127 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 111 scientists 82–83 D-Index: 110 scientists 84–85 D-Index: 110 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 102 scientists 90–91 D-Index: 66 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 70 scientists 96–97 D-Index: 54 scientists 98–99 D-Index: 60 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 55 scientists 104–105 D-Index: 45 scientists 106–107 D-Index: 42 scientists 108–109 D-Index: 28 scientists 110–111 D-Index: 39 scientists 112–113 D-Index: 25 scientists 114–115 D-Index: 31 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 34 scientists 120–121 D-Index: 29 scientists 122–123 D-Index: 29 scientists 124–125 D-Index: 18 scientists 126–127 D-Index: 27 scientists 128–129 D-Index: 22 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 11 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 12 scientists 138–139 D-Index: 21 scientists 140–141 D-Index: 4 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 14 scientists 146–147 D-Index: 6 scientists 148–149 D-Index: 10 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 9 scientists 154–155 D-Index: 8 scientists 156–157 D-Index: 8 scientists 158–159 D-Index: 9 scientists 160+ D-Index: 96 scientists
40 D-Index 160+

This scientist: 102 D-Index — 84th percentile

84% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 160 D-Index or more.

Overview

David E. Root is a researcher affiliated with MIT in the United States with a focus on the intersection of biochemistry, genetics, molecular biology, and medicine. Their work concentrates on molecular biology, genetics, cancer research, oncology, and pulmonary and respiratory medicine.

The scientific topics covered extensively in their publications include CRISPR and genetic engineering, protein degradation and inhibitors, cancer genomics and diagnostics, ubiquitin and proteasome pathways, chromatin remodeling and cancer, glioma diagnosis and treatment, and epigenetics and DNA methylation.

David E. Root has been published prominently in several journals. The most frequent venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Nature Communications
  • Cancer Discovery

Examples of their recent scientific papers are:

  • Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects, 2021, Genome Biology
  • In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer, 2022, Nature Immunology
  • Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer, 2020, Clinical Cancer Research
  • Noncanonical open reading frames encode functional proteins essential for cancer cell survival, 2021, Nature Biotechnology
  • Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers, 2021, Nature Genetics

Frequent collaborators with David E. Root include:

  • Federica Piccioni
  • William C. Hahn
  • Amy Goodale
  • Nicole S. Persky
  • Francisca Vázquez

Best Publications

  • Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

    Ophir Shalem;Ophir Shalem;Neville E Sanjana;Neville E Sanjana;Ella Hartenian;Xi-Shun Shi

  • Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

    John G Doench;Nicolo Fusi;Meagan Sullender;Mudra Hegde

  • A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

    Aravind Subramanian;Rajiv Narayan;Steven M. Corsello;Steven M. Corsello;David D. Peck

  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

    David A. Barbie;Pablo Tamayo;Jesse S. Boehm;So Young Kim

  • Defining a Cancer Dependency Map

    Aviad Tsherniak;Francisca Vazquez;Francisca Vazquez;Phil G. Montgomery;Barbara A. Weir;Barbara A. Weir

  • lincRNAs act in the circuitry controlling pluripotency and differentiation

    Mitchell Guttman;Julie Donaghey;Bryce W. Carey;Manuel Garber

  • A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

    Jason Moffat;Dorre A. Grueneberg;Xiaoping Yang;So Young Kim;So Young Kim

  • Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

    Robin M Meyers;Jordan G Bryan;James M McFarland;Barbara A Weir

  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Cory M Johannessen;Jesse S. Boehm;So Young Kim;Sapana R. Thomas;Sapana R. Thomas

  • Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

    John G Doench;Ella Hartenian;Daniel B Graham;Zuzana Tothova

  • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

    Richard Possemato;Kevin M. Marks;Yoav D. Shaul;Michael E. Pacold

  • In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

    Robert T. Manguso;Robert T. Manguso;Hans W. Pope;Hans W. Pope;Margaret D. Zimmer;Margaret D. Zimmer;Flavian D. Brown

  • Identification of RPS14 as a 5q - syndrome gene by RNA interference screen

    Benjamin L. Ebert;Jennifer Pretz;Jocelyn Bosco;Cindy Y. Chang

  • The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

    Lauren L.C. Marotta;Vanessa Almendro;Vanessa Almendro;Andriy Marusyk;Michail Shipitsin

  • β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

    Joseph Rosenbluh;Deepak Nijhawan;Deepak Nijhawan;Deepak Nijhawan;Andrew G. Cox;Andrew G. Cox;Xingnan Li

  • Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

    Jordi Barretina;Barry S Taylor;Barry S Taylor;Shantanu Banerji;Shantanu Banerji;Alexis H Ramos;Alexis H Ramos

  • CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

    Ron Firestein;Adam Bass;So Young Kim;Ian Frederick Dunn

  • KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

    Diane D. Shao;Wen Xue;Elsa B. Krall;Elsa B. Krall;Arjun Bhutkar

  • Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Kendall R. Sanson;Ruth E. Hanna;Mudra Hegde;Katherine F. Donovan

  • (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

    Julie Aurore Losman;Ryan E. Looper;Peppi Koivunen;Sungwoo Lee

Frequent Co-Authors

William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Todd R. Golub
Todd R. Golub Harvard University
Jesse S. Boehm
Jesse S. Boehm Broad Institute
Francisca Vazquez
Francisca Vazquez Broad Institute
John G. Doench
John G. Doench Broad Institute
Aviad Tsherniak
Aviad Tsherniak Broad Institute
Levi A. Garraway
Levi A. Garraway Roche (United States)
Barbara A. Weir
Barbara A. Weir Janssen (United States)
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University

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