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Aviad Tsherniak

Aviad Tsherniak

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
26009
World Ranking
14141
National Ranking
5962

Overview

Aviad Tsherniak is a researcher affiliated with the Broad Institute in the United States. Their work spans multiple aspects of biomedical science, with a particular focus on genetics, molecular biology, and cancer research.

Their main fields of study include Biochemistry, Genetics and Molecular Biology, and Medicine. Subfields where the researcher has contributed include Molecular Biology, Genetics, Oncology, Hematology, and Cancer Research. Their research topics cover a diverse range of areas such as:

  • CRISPR and Genetic Engineering
  • Single-cell and spatial transcriptomics
  • Protein Degradation and Inhibitors
  • Cancer Genomics and Diagnostics
  • Multiple Myeloma Research and Treatments
  • Cell Image Analysis Techniques
  • Evolution and Genetic Dynamics

Aviad Tsherniak has published regularly in several journals, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Cancer Research
  • Nature Communications
  • Nature Genetics

Notable recent papers by Tsherniak include:

  • "Discovering the anticancer potential of non-oncology drugs by systematic viability profiling" (2020, Nature Cancer)
  • "Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity" (2020, Nature Genetics)
  • "Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects" (2021, Genome Biology)
  • "Integrated cross-study datasets of genetic dependencies in cancer" (2021, Nature Communications)
  • "An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence" (2021, Cancer Cell)

The researcher has collaborated frequently with several other scientists, including:

  • Francisca Vázquez (31 coauthored publications)
  • William C. Hahn (22 coauthored publications)
  • James M. McFarland (20 coauthored publications)
  • Jesse S. Boehm (19 coauthored publications)
  • Todd R. Golub (16 coauthored publications)

Best Publications

  • Next-generation characterization of the Cancer Cell Line Encyclopedia

    Mahmoud Ghandi;Franklin W. Huang;Franklin W. Huang;Franklin W. Huang;Judit Jané-Valbuena;Judit Jané-Valbuena;Gregory V. Kryukov

  • Defining a Cancer Dependency Map

    Aviad Tsherniak;Francisca Vazquez;Francisca Vazquez;Phil G. Montgomery;Barbara A. Weir;Barbara A. Weir

  • Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

    Robin M Meyers;Jordan G Bryan;James M McFarland;Barbara A Weir

  • β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

    Joseph Rosenbluh;Deepak Nijhawan;Deepak Nijhawan;Deepak Nijhawan;Andrew G. Cox;Andrew G. Cox;Xingnan Li

  • Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

    Yoon Jae Cho;Aviad Tsherniak;Pablo Tamayo;Sandro Santagata

  • Genetic and transcriptional evolution alters cancer cell line drug response

    Uri Ben-David;Benjamin Siranosian;Gavin Ha;Gavin Ha;Helen Tang

  • Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

    Roel G.W. Verhaak;Pablo Tamayo;Ji Yeon Yang;Diana Hubbard

  • Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.

    Steven M. Corsello;Steven M. Corsello;Rohith T. Nagari;Ryan D. Spangler;Jordan Rossen

  • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

    Andrew J Aguirre;Robin M Meyers;Barbara A. Weir;Francisca Vázquez

  • Mitochondrial metabolism promotes adaptation to proteotoxic stress.

    Peter Tsvetkov;Alexandre Detappe;Kai Cai;Heather R Keys

  • MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.

    Gregory V. Kryukov;Gregory V. Kryukov;Frederick H. Wilson;Frederick H. Wilson;Jason R. Ruth;Jason R. Ruth;Joshiawa Paulk;Joshiawa Paulk

  • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

    Hiu Wing Cheung;Glenn S. Cowley;Barbara A. Weir;Jesse S. Boehm

  • Mutational processes shape the landscape of TP53 mutations in human cancer

    Andrew O. Giacomelli;Andrew O. Giacomelli;Xiaoping Yang;Robert E. Lintner;James M. McFarland

  • Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

    Glenn S Cowley;Barbara A Weir;Barbara A Weir;Francisca Vazquez;Francisca Vazquez;Pablo Tamayo

  • The landscape of cancer cell line metabolism

    Haoxin Li;Haoxin Li;Shaoyang Ning;Mahmoud Ghandi;Gregory V. Kryukov

  • Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines

    Dempster Jm;Rossen J;Kazachkova M;Pan J

  • Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

    James M. McFarland;Zandra V. Ho;Guillaume Kugener;Joshua M. Dempster

  • High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

    Channing Yu;Aristotle M. Mannan;Griselda Metta Yvone;Kenneth N. Ross

  • WRN helicase is a synthetic lethal target in microsatellite unstable cancers.

    Edmond M Chan;Edmond M Chan;Tsukasa Shibue;James M McFarland;Benjamin Gaeta

  • Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.

    Gabriela S Kinker;Gabriela S Kinker;Alissa C Greenwald;Rotem Tal;Zhanna Orlova

Frequent Co-Authors

William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Francisca Vazquez
Francisca Vazquez Broad Institute
Todd R. Golub
Todd R. Golub Harvard University
David E. Root
David E. Root Broad Institute
Jesse S. Boehm
Jesse S. Boehm Broad Institute
Barbara A. Weir
Barbara A. Weir Janssen (United States)
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Levi A. Garraway
Levi A. Garraway Roche (United States)
Matthew Meyerson
Matthew Meyerson Harvard University
Jill P. Mesirov
Jill P. Mesirov University of California, San Diego

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