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Biology and Biochemistry

D-Index
63
Citations
44851
World Ranking
9944
National Ranking
4351

Overview

Jesse S. Boehm is affiliated with the Broad Institute in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a significant focus on Molecular Biology and Cancer Research. The subfields of their study include Genetics, Oncology, and Infectious Diseases.

The scientist's work covers main topics such as Cancer Genomics and Diagnostics, CRISPR and Genetic Engineering, Single-cell and Spatial Transcriptomics, Evolution and Genetic Dynamics, Renal and related cancers, Cancer Cells and Metastasis, and Cell Image Analysis Techniques.

Jesse S. Boehm has contributed to numerous publications, with frequent appearances in the following venues:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Nature Cancer
  • Genome biology

Their recent papers include:

  • Discovering the anticancer potential of non-oncology drugs by systematic viability profiling, 2020, Nature Cancer
  • Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects, 2021, Genome biology
  • An expanded universe of cancer targets, 2021, Cell
  • A first-generation pediatric cancer dependency map, 2021, Nature Genetics
  • Global computational alignment of tumor and cell line transcriptional profiles, 2021, Nature Communications

Jesse S. Boehm frequently collaborates with a group of co-authors, including William C. Hahn, Francisca Vázquez, James M. McFarland, David E. Root, and Aviad Tsherniak. These collaborations reflect ongoing research efforts within cancer biology and genetic engineering disciplines.

Best Publications

  • The landscape of somatic copy-number alteration across human cancers

    Rameen Beroukhim;Craig H. Mermel;Craig H. Mermel;Dale Porter;Guo Wei

  • A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

    Aravind Subramanian;Rajiv Narayan;Steven M. Corsello;Steven M. Corsello;David D. Peck

  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

    David A. Barbie;Pablo Tamayo;Jesse S. Boehm;So Young Kim

  • Next-generation characterization of the Cancer Cell Line Encyclopedia

    Mahmoud Ghandi;Franklin W. Huang;Franklin W. Huang;Franklin W. Huang;Judit Jané-Valbuena;Judit Jané-Valbuena;Gregory V. Kryukov

  • Defining a Cancer Dependency Map

    Aviad Tsherniak;Francisca Vazquez;Francisca Vazquez;Phil G. Montgomery;Barbara A. Weir;Barbara A. Weir

  • Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

    Robin M Meyers;Jordan G Bryan;James M McFarland;Barbara A Weir

  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Cory M Johannessen;Jesse S. Boehm;So Young Kim;Sapana R. Thomas;Sapana R. Thomas

  • Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

    Vasanthi S. Viswanathan;Matthew J. Ryan;Harshil D. Dhruv;Shubhroz Gill

  • Organoid Modeling of the Tumor Immune Microenvironment.

    James T. Neal;Xingnan Li;Junjie Zhu;Valeria Giangarra

  • Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

    Viktor A. Adalsteinsson;Viktor A. Adalsteinsson;Gavin Ha;Gavin Ha;Samuel S. Freeman;Samuel S. Freeman;Atish D. Choudhury

  • CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

    Ron Firestein;Adam Bass;So Young Kim;Ian Frederick Dunn

  • Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

    Jesse S. Boehm;Jean J. Zhao;Jun Yao;So Young Kim

  • Patient-derived xenografts undergo mouse-specific tumor evolution.

    Uri Ben-David;Gavin Ha;Gavin Ha;Yuen-Yi Tseng;Noah F Greenwald;Noah F Greenwald;Noah F Greenwald

  • A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

    Yilong Zou;Yilong Zou;Michael J. Palte;Amy A. Deik;Haoxin Li;Haoxin Li

  • Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.

    Steven M. Corsello;Steven M. Corsello;Rohith T. Nagari;Ryan D. Spangler;Jordan Rossen

  • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

    Claudia Scholl;Stefan Fröhling;Ian F. Dunn;Anna C. Schinzel

  • Highly parallel identification of essential genes in cancer cells

    Biao Luo;Hiu Wing Cheung;Aravind Subramanian;Tanaz Sharifnia

  • AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

    Krishna M. Vasudevan;David A. Barbie;David A. Barbie;Michael A. Davies;Rosalia Rabinovsky

  • A public genome-scale lentiviral expression library of human ORFs

    Xiaoping Yang;Jesse S Boehm;Xinping Yang;Kourosh Salehi-Ashtiani

  • Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

    Eliezer M Van Allen;Kent W. Mouw;Philip Kim;Gopa Iyer

Frequent Co-Authors

William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Todd R. Golub
Todd R. Golub Harvard University
David E. Root
David E. Root Broad Institute
Francisca Vazquez
Francisca Vazquez Broad Institute
Aviad Tsherniak
Aviad Tsherniak Broad Institute
Levi A. Garraway
Levi A. Garraway Roche (United States)
Matthew Meyerson
Matthew Meyerson Harvard University
Barbara A. Weir
Barbara A. Weir Janssen (United States)
Gad Getz
Gad Getz Broad Institute
Pablo Tamayo
Pablo Tamayo University of California, San Diego

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