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Medicine

D-Index
146
Citations
92498
World Ranking
1327
National Ranking
768

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David B. Solit is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research contributions span multiple areas within medicine, biochemistry, genetics, and molecular biology, with a focused emphasis on cancer research and oncology.

Their work covers several prominent subfields, including surgery, molecular biology, cancer research, pulmonary and respiratory medicine, and oncology. The main topics explored in their publications include cancer genomics and diagnostics, bladder and urothelial cancer treatments, epigenetics and DNA methylation, urinary and genital oncology studies, genetic factors in colorectal cancer, cancer immunotherapy and biomarkers, and lung cancer treatments and mutations.

Some of their recent papers highlight significant studies in cancer biology and clinical applications. These include:

  • "Cancer therapy shapes the fitness landscape of clonal hematopoiesis" (2020, Nature Genetics)
  • "Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients" (2022, Cell)
  • "First-line pembrolizumab and trastuzumab in HER2-positive oesophageal, gastric, or gastro-oesophageal junction cancer: an open-label, single-arm, phase 2 trial" (2020, The Lancet Oncology)
  • "Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer" (2023, Cancer Discovery)
  • "HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers" (2020, Cancer Discovery)

Frequent frequent coauthors collaborating with David B. Solit include:

  • Michael F. Berger
  • Hikmat Al-Ahmadie
  • Nikolaus Schultz
  • Eugene J. Pietzak
  • Gopa Iyer

Their research has been published extensively in venues such as:

  • Journal of Clinical Oncology (53 publications)
  • Cancer Research (51 publications)
  • Clinical Cancer Research (30 publications)
  • The Journal of Urology (29 publications)
  • Nature Communications (12 publications)

Best Publications

  • Comprehensive molecular characterization of human colon and rectal cancer

    Donna M. Muzny;Matthew N. Bainbridge;Kyle Chang;Huyen H. Dinh

  • Tumor mutational load predicts survival after immunotherapy across multiple cancer types.

    Robert M Samstein;Chung-Han Lee;Chung-Han Lee;Alexander N Shoushtari;Alexander N Shoushtari;Matthew D Hellmann;Matthew D Hellmann

  • Comprehensive molecular characterization of urothelial bladder carcinoma

    John N Weinstein;Rehan Akbani;Bradley McIntosh Broom;Wenyi Wang

  • Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

    Ahmet Zehir;Ryma Benayed;Ronak H Shah;Aijazuddin Syed

  • mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

    Kathryn E. O'Reilly;Fredi Rojo;Qing Bai She;David Solit

  • OncoKB: A Precision Oncology Knowledge Base.

    Debyani Chakravarty;Jianjiong Gao;Sarah Phillips;Ritika Kundra

  • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

    Sandra Misale;Rona Yaeger;Sebastijan Hobor;Elisa Scala

  • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

    Ravid Straussman;Teppei Morikawa;Kevin Shee;Michal Barzily-Rokni

  • AACR project genie: Powering precision medicine through an international consortium

    S. M. Sweeney;E. Cerami;A. Baras;T. J. Pugh

  • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

    Poulikos I. Poulikakos;Yogindra Persaud;Manickam Janakiraman;Xiangju Kong

  • Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

    Colin C. Pritchard;Joaquin Mateo;Michael F. Walsh;Navonil De Sarkar

  • BRAF mutation predicts sensitivity to MEK inhibition

    David B. Solit;Levi A. Garraway;Levi A. Garraway;Christine A. Pratilas;Ayana Sawai

  • Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.

    Hira Rizvi;Francisco Sanchez-Vega;Konnor La;Walid Chatila

  • Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

    Diego Chowell;Luc G. T. Morris;Claud M. Grigg;Jeffrey K. Weber

  • The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.

    Pedram Razavi;Matthew T. Chang;Guotai Xu;Chaitanya Bandlamudi

  • Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

    Andrea D. Basso;Andrea D. Basso;David B. Solit;Gabriela Chiosis;Banabihari Giri

  • Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

    Matthew T Chang;Saurabh Asthana;Sizhi Paul Gao;Byron H Lee

  • Genome Sequencing Identifies a Basis for Everolimus Sensitivity

    Gopa Iyer;Gopa Iyer;Aphrothiti J. Hanrahan;Matthew Ivan Milowsky;Matthew Ivan Milowsky;Hikmat Al-Ahmadie

  • Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

    Rona Yaeger;Walid K. Chatila;Marla D. Lipsyc;Jaclyn F. Hechtman

  • HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

    David M. Hyman;Sarina A. Piha-Paul;Helen Won;Jordi Rodon

Frequent Co-Authors

Michael F. Berger
Michael F. Berger Memorial Sloan Kettering Cancer Center
Dean F. Bajorin
Dean F. Bajorin Memorial Sloan Kettering Cancer Center
David M. Hyman
David M. Hyman Memorial Sloan Kettering Cancer Center
Hikmat Al-Ahmadie
Hikmat Al-Ahmadie Memorial Sloan Kettering Cancer Center
Jonathan E. Rosenberg
Jonathan E. Rosenberg Memorial Sloan Kettering Cancer Center
Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
Nikolaus Schultz
Nikolaus Schultz Memorial Sloan Kettering Cancer Center
Barry S. Taylor
Barry S. Taylor Memorial Sloan Kettering Cancer Center
Bernard H. Bochner
Bernard H. Bochner Memorial Sloan Kettering Cancer Center
Ahmet Zehir
Ahmet Zehir Natera (United States)

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