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Medicine

D-Index
133
Citations
111755
World Ranking
2172
National Ranking
230

Research.com Recognitions

  • 2018 - Fellow of the Royal Society, United Kingdom

Overview

Charles Swanton is affiliated with The Francis Crick Institute in the United Kingdom. Their research spans multiple domains within medicine and biochemistry, genetics, and molecular biology, with a particular emphasis on oncology and cancer research.

The scientist's work frequently appears in prominent publication venues, including:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of Oncology
  • Zenodo (CERN European Organization for Nuclear Research)
  • ESMO Open

Swanton's research focuses mainly on oncology and related subfields such as molecular biology, infectious diseases, and pulmonary and respiratory medicine. Their primary topics include:

  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • SARS-CoV-2 and COVID-19 Research
  • Lung Cancer Treatments and Mutations
  • Immunotherapy and Immune Responses
  • COVID-19 Clinical Research Studies
  • RNA modifications and cancer

Among recent publications, several notable papers include:

  • "Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA" (2020, Annals of Oncology)
  • "Preexisting and de novo humoral immunity to SARS-CoV-2 in humans" (2020, Science)
  • "Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set" (2021, Annals of Oncology)
  • "Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition" (2021, Cell)
  • "Liquid Biopsy for Advanced NSCLC: A Consensus Statement From the International Association for the Study of Lung Cancer" (2021, Journal of Thoracic Oncology)

Frequent collaborators in Swanton's work include:

  • Mariam Jamal-Hanjani
  • Nicholas McGranahan
  • Kevin Litchfield
  • George Kassiotis
  • Sonia Gandhi

Swanton was awarded the distinction of Fellow of the Royal Society, United Kingdom, in 2018.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

    Marco Gerlinger;Andrew J. Rowan;Stuart Horswell;James Larkin

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    Nicholas McGranahan;Nicholas McGranahan;Andrew J. S. Furness;Rachel Rosenthal;Sofie Ramskov

  • Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

    T.A. Chan;M. Yarchoan;E. Jaffee;C. Swanton

  • The causes and consequences of genetic heterogeneity in cancer evolution.

    Rebecca A. Burrell;Nicholas McGranahan;Nicholas McGranahan;Jiri Bartek;Charles Swanton

  • Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.

    Nicholas McGranahan;Charles Swanton;Charles Swanton

  • Tracking the Evolution of Non–Small-Cell Lung Cancer

    Mariam Jamal-Hanjani;Gareth A. Wilson;Nicholas McGranahan;Nicolai Juul Birkbak

  • Renal cell carcinoma.

    James J. Hsieh;Mark P. Purdue;Sabina Signoretti;Charles Swanton

  • Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

    Christopher Abbosh;Nicolai J. Birkbak;Nicolai J. Birkbak;Gareth A. Wilson;Gareth A. Wilson;Mariam Jamal-Hanjani

  • Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

    Marco Gerlinger;Stuart Horswell;James Larkin;Andrew J Rowan

  • Artificial intelligence in cancer imaging: Clinical challenges and applications.

    Wenya Linda Bi;Ahmed Hosny;Matthew B. Schabath;Maryellen L. Giger

  • Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

    Nicholas McGranahan;Rachel Rosenthal;Crispin T. Hiley;Crispin T. Hiley;Andrew J. Rowan

  • Chromosomal instability drives metastasis through a cytosolic DNA response.

    Samuel F. Bakhoum;Samuel F. Bakhoum;Bryan Ngo;Ashley M. Laughney;Julie Ann Cavallo;Julie Ann Cavallo

  • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

    Elza C. de Bruin;Nicholas McGranahan;Nicholas McGranahan;Richard Mitter;Max Salm

  • Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

    Nicholas McGranahan;Nicholas McGranahan;Charles Swanton

  • deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

    Rachel Rosenthal;Rachel Rosenthal;Nicholas McGranahan;Nicholas McGranahan;Javier Herrero;Barry S. Taylor

  • Cancer heterogeneity: implications for targeted therapeutics

    R Fisher;L Pusztai;C Swanton;C Swanton

  • Intratumor heterogeneity: evolution through space and time.

    Charles Swanton

  • Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

    M C Liu;G R Oxnard;E A Klein;C Swanton

Frequent Co-Authors

Nicholas McGranahan
Nicholas McGranahan University College London
Zoltan Szallasi
Zoltan Szallasi Boston Children's Hospital
Samra Turajlic
Samra Turajlic Royal Marsden NHS Foundation Trust
James Larkin
James Larkin Royal Marsden NHS Foundation Trust
Sergio A. Quezada
Sergio A. Quezada University College London
Julian Downward
Julian Downward The Francis Crick Institute
Javier Herrero
Javier Herrero University College London
Peter Van Loo
Peter Van Loo The Francis Crick Institute
Michael Howell
Michael Howell The Francis Crick Institute
Caroline Dive
Caroline Dive University of Manchester

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