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Biology and Biochemistry

D-Index
61
Citations
13750
World Ranking
11318
National Ranking
870

Overview

Trevor A. Graham is a researcher affiliated with the Institute of Cancer Research in the United Kingdom. Their work principally spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on Molecular Biology, Cancer Research, Oncology, Pathology and Forensic Medicine, and Genetics.

Their research topics include:

  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • Single-cell and spatial transcriptomics
  • Molecular Biology Techniques and Applications
  • Inflammatory Bowel Disease
  • Evolution and Genetic Dynamics
  • Epigenetics and DNA Methylation

Recent significant publications by Graham demonstrate a concentration on cancer biology and genetic evolution within tumors. Key papers include:

  • "Cancer associated fibroblast FAK regulates malignant cell metabolism" (2020, Nature Communications)
  • "Phenotypic plasticity and genetic control in colorectal cancer evolution" (2022, Nature)
  • "Subclonal reconstruction of tumors by using machine learning and population genetics" (2020, Nature Genetics)
  • "Evolutionary dynamics of neoantigens in growing tumors" (2020, Nature Genetics)
  • "The co-evolution of the genome and epigenome in colorectal cancer" (2022, Nature)

Graham collaborates frequently with several researchers, including:

  • Ann-Marie Baker
  • Andrea Sottoriva
  • Eszter Lakatos
  • Jacob Househam
  • Christopher Kimberley

Their work is commonly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Communications
  • Nature

Best Publications

  • A Big Bang model of human colorectal tumor growth

    Andrea Sottoriva;Haeyoun Kang;Zhicheng Ma;Trevor A Graham

  • Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

    Noemi Andor;Trevor A Graham;Marnix Jansen;Li C Xia

  • Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

    Daniel L. Worthley;Michael Churchill;Jocelyn T. Compton;Yagnesh Tailor

  • Identification of neutral tumor evolution across cancer types.

    Marc J Williams;Benjamin Werner;Chris P Barnes;Trevor A Graham

  • Resolving genetic heterogeneity in cancer.

    Samra Turajlic;Samra Turajlic;Andrea Sottoriva;Trevor Graham;Charles Swanton;Charles Swanton

  • Classifying the evolutionary and ecological features of neoplasms

    Carlo C. Maley;Athena Aktipis;Trevor A. Graham;Andrea Sottoriva

  • An evolutionary perspective on field cancerization.

    Kit Curtius;Nicholas A Wright;Trevor A Graham

  • Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview

    Chang-Ho Ryan Choi;Matthew D Rutter;Alan Askari;Gui Han Lee

  • Quantification of subclonal selection in cancer from bulk sequencing data.

    Marc J Williams;Marc J Williams;Benjamin Werner;Timon Heide;Christina Curtis

  • Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

    Ann-Marie Baker;Biancastella Cereser;Samuel Melton;Alexander G. Fletcher

  • Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.

    Simon J. Leedham;Trevor A. Graham;Dahmane Oukrif;Stuart A.C. McDonald

  • Krt19(+)/Lgr5(−) cells are radioresistant cancer initiating stem cells in the colon and intestine

    Samuel Asfaha;Samuel Asfaha;Yoku Hayakawa;Ashlesha Muley;Sarah Stokes

  • Detecting repeated cancer evolution from multi-region tumor sequencing data

    Giulio Caravagna;Ylenia Giarratano;Daniele Ramazzotti;Ian Tomlinson

  • Stem cells and their implications for colorectal cancer.

    Sebastian S. Zeki;Trevor A. Graham;Nicholas A. Wright

  • Clonal evolution of colorectal cancer in IBD

    Chang-Ho R. Choi;Ibrahim Al Bakir;Ailsa L. Hart;Trevor A. Graham

  • Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas

    Christina Thirlwell;Olivia C.C. Will;E. Domingo;Trevor A. Graham

  • Between-region genetic divergence reflects the mode and tempo of tumor evolution

    Ruping Sun;Zheng Hu;Andrea Sottoriva;Trevor A Graham

  • Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study.

    Chang-Ho Ryan Choi;Ibrahim Al Bakir;Nik-Sheng John Ding;Gui-Han Lee

  • Low-Grade Dysplasia in Ulcerative Colitis: Risk Factors for Developing High-Grade Dysplasia or Colorectal Cancer

    Chang-ho Ryan Choi;Ana Ignjatovic-Wilson;Alan Askari;Gui Han Lee

  • Measuring cancer evolution from the genome

    Trevor A Graham;Andrea Sottoriva

Frequent Co-Authors

Nicholas A. Wright
Nicholas A. Wright Queen Mary University of London
Ailsa Hart
Ailsa Hart Imperial College London
Ian Tomlinson
Ian Tomlinson University of Oxford
Carlo C. Maley
Carlo C. Maley Arizona State University
Alexander R. A. Anderson
Alexander R. A. Anderson Moffitt Cancer Center
Richard Poulsom
Richard Poulsom Queen Mary University of London
Janusz Jankowski
Janusz Jankowski University College of Osteopathy
Charles Swanton
Charles Swanton The Francis Crick Institute
Guido Sanguinetti
Guido Sanguinetti International School for Advanced Studies
Benjamin D. Simons
Benjamin D. Simons University of Cambridge

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