David C. Wedge mainly investigates Genetics, Mutation, Cancer, Genome and Somatic evolution in cancer. His study in Genetics concentrates on Kataegis, DNA Mutational Analysis, APOBEC, Lineage and Somatic cell. David C. Wedge works mostly in the field of APOBEC, limiting it down to concerns involving Cytidine deaminase and, occasionally, Genome instability and Chromosome instability.
He studies Germline mutation which is a part of Mutation. David C. Wedge interconnects Cancer research and H3F3B in the investigation of issues within Cancer. As part of one scientific family, David C. Wedge deals mainly with the area of Genome, narrowing it down to issues related to the Computational biology, and often Whole genome sequencing, Germline, Massive parallel sequencing and Chromothripsis.
David C. Wedge mostly deals with Genetics, Cancer, Cancer research, Genome and Internal medicine. His study in Mutation, Germline mutation, Gene, Somatic cell and Exome sequencing falls within the category of Genetics. David C. Wedge is involved in the study of Mutation that focuses on DNA Mutational Analysis in particular.
His work on Breast cancer and Somatic evolution in cancer as part of general Cancer study is frequently linked to Context, bridging the gap between disciplines. His Genome research incorporates elements of Computational biology and Genome instability. In his research on the topic of Internal medicine, Tumour heterogeneity is strongly related with Oncology.
His primary scientific interests are in Computational biology, Genome, Cancer, Gene mutation and Internal medicine. His Computational biology research is multidisciplinary, relying on both Acquired immune system, Exome sequencing, Genotyping and DNA sequencing. His studies in Genome integrate themes in fields like Carcinogenesis, Tumor heterogeneity, Germline mutation and Evolutionary biology.
His Carcinogenesis study is focused on Genetics in general. His Cancer study incorporates themes from SCNA, Cancer research, Epigenetics and DNA methylation. His studies deal with areas such as Lineage and Oncology as well as Internal medicine.
His primary areas of study are Genome, Human genetics, Computational biology, Internal medicine and Oncology. His Genome study combines topics in areas such as Carcinogenesis, Isochromosome and Genome instability. Carcinogenesis is a subfield of Genetics that David C. Wedge explores.
His research integrates issues of Cancer, Tumor heterogeneity, Cancer evolution, Germline mutation and DNA sequencing in his study of Computational biology. David C. Wedge has included themes like Genetic heterogeneity, Cancer research, Lung cancer and Epigenetics in his Cancer study. His biological study spans a wide range of topics, including Aneuploidy and Histopathology.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio.
Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
J. Nangalia;C.E. Massie;E.J. Baxter;F.L. Nice.
The New England Journal of Medicine (2013)
The landscape of cancer genes and mutational processes in breast cancer
Philip J. Stephens;Patrick S. Tarpey;Helen Davies;Peter Van Loo;Peter Van Loo.
Mutational Processes Molding the Genomes of 21 Breast Cancers
Serena Nik-Zainal;Ludmil B. Alexandrov;David C. Wedge;Peter Van Loo;Peter Van Loo;Peter Van Loo.
Clinical and biological implications of driver mutations in myelodysplastic syndromes.
Elli Papaemmanuil;Moritz Gerstung;Luca Malcovati;Sudhir Tauro.
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Serena Nik-Zainal;Serena Nik-Zainal;Helen Davies;Johan Staaf;Manasa Ramakrishna.
Pan-cancer analysis of whole genomes
Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart.
The Life History of 21 Breast Cancers
Serena Nik-Zainal;Peter Van Loo;Peter Van Loo;Peter Van Loo;David C. Wedge;Ludmil B. Alexandrov.
High burden and pervasive positive selection of somatic mutations in normal human skin
Iñigo Martincorena;Amit Roshan;Moritz Gerstung;Peter Ellis.
The evolutionary history of lethal metastatic prostate cancer.
Gunes Gundem;Peter Van Loo;Peter Van Loo;Peter Van Loo;Barbara Kremeyer;Ludmil B. Alexandrov.
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: