World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
79
Citations
57378
World Ranking
1604
National Ranking
207

Overview

David C. Wedge is affiliated with the University of Manchester in the United Kingdom. Their research spans several interconnected fields within biochemistry, genetics, molecular biology, and medicine, with a particular focus on cancer genomics and diagnostics.

The scientist's recent publications address a range of topics related to cancer genetics and tumor biology. Notable papers include:

  • Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes, 2021, Cell
  • Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition, 2020, Nature Genetics
  • Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor, 2022, Cell Genomics
  • Promises and challenges of adoptive T-cell therapies for solid tumours, 2021, British Journal of Cancer
  • Genomic and evolutionary classification of lung cancer in never smokers, 2021, Nature Genetics

Wedge frequently collaborates with other researchers in their field. Their most common co-authors include:

  • Ludmil B. Alexandrov
  • Peter Van Loo
  • Tongwu Zhang
  • Andreas Gruber
  • Stefan C. Dentro

The scientist has published extensively in several major venues relevant to genetics and cancer research. Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cancer Research
  • Nature Genetics
  • Nature

Their primary fields of study are biochemistry, genetics, and molecular biology, as well as medicine. These broad areas break down into specific subfields that frame much of their research:

  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Genetics
  • Oncology

The main topics covered across their publications focus predominantly on cancer and include:

  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • Epigenetics and DNA Methylation
  • Prostate Cancer Treatment and Research
  • RNA modifications and cancer
  • Prostate Cancer Diagnosis and Treatment
  • Lung Cancer Treatments and Mutations

Best Publications

  • Signatures of mutational processes in human cancer

    Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences

    Serena Nik-Zainal;Serena Nik-Zainal;Helen Davies;Johan Staaf;Manasa Ramakrishna

  • Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

    J. Nangalia;C.E. Massie;E.J. Baxter;F.L. Nice

  • Mutational Processes Molding the Genomes of 21 Breast Cancers

    Serena Nik-Zainal;Ludmil B. Alexandrov;David C. Wedge;Peter Van Loo;Peter Van Loo;Peter Van Loo

  • Clinical and biological implications of driver mutations in myelodysplastic syndromes.

    Elli Papaemmanuil;Moritz Gerstung;Luca Malcovati;Sudhir Tauro

  • The landscape of cancer genes and mutational processes in breast cancer

    Philip J. Stephens;Patrick S. Tarpey;Helen Davies;Peter Van Loo;Peter Van Loo

  • High burden and pervasive positive selection of somatic mutations in normal human skin

    Iñigo Martincorena;Amit Roshan;Moritz Gerstung;Peter Ellis

  • The Life History of 21 Breast Cancers

    Serena Nik-Zainal;Peter Van Loo;Peter Van Loo;Peter Van Loo;David C. Wedge;Ludmil B. Alexandrov

  • The evolutionary history of lethal metastatic prostate cancer.

    Gunes Gundem;Peter Van Loo;Peter Van Loo;Peter Van Loo;Barbara Kremeyer;Ludmil B. Alexandrov

  • Deciphering Signatures of Mutational Processes Operative in Human Cancer

    Ludmil B. Alexandrov;Serena Nik-Zainal;David C. Wedge;Peter J. Campbell;Peter J. Campbell

  • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

    Elza C. de Bruin;Nicholas McGranahan;Nicholas McGranahan;Richard Mitter;Max Salm

  • Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

    Jianjun Zhang;Junya Fujimoto;Jianhua Zhang;David C. Wedge

  • The evolutionary history of 2,658 cancers

    Moritz Gerstung;Moritz Gerstung;Clemency Jolly;Ignaty Leshchiner;Stefan C Dentro;Stefan C Dentro;Stefan C Dentro

  • Clock-like mutational processes in human somatic cells

    Ludmil B Alexandrov;Philip H Jones;Philip H Jones;David C Wedge;Julian E Sale

  • Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

    Niccolo Bolli;Hervé Avet-Loiseau;David C. Wedge;Peter Van Loo

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Subclonal diversification of primary breast cancer revealed by multiregion sequencing

    Lucy R. Yates;Moritz Gerstung;Stian Knappskog;Christine Desmedt

  • Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

    Sam Behjati;Sam Behjati;Patrick S Tarpey;Nadège Presneau;Susanne Scheipl;Susanne Scheipl

  • Genomic Evolution of Breast Cancer Metastasis and Relapse

    Lucy R. Yates;Stian Knappskog;Stian Knappskog;David Wedge;David Wedge;James H.R. Farmery

Frequent Co-Authors

Peter Van Loo
Peter Van Loo The Francis Crick Institute
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Ludmil B. Alexandrov
Ludmil B. Alexandrov University of California, San Diego
Moritz Gerstung
Moritz Gerstung German Cancer Research Center
Keiran Raine
Keiran Raine Wellcome Sanger Institute
Anne Lise Børresen-Dale
Anne Lise Børresen-Dale Oslo University Hospital
Jon W. Teague
Jon W. Teague Wellcome Sanger Institute
Inigo Martincorena
Inigo Martincorena Wellcome Sanger Institute
Adam Butler
Adam Butler Wellcome Sanger Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Genetics can open doors to a variety of healthcare and science careers. For those interested in online education, there are several flexible pathways to consider. Many professionals start in a clinical or healthcare role and then upskill with further study.

For example, registered nurses aiming to broaden their knowledge may benefit from rn to bsn online options, which build on foundational nursing skills without requiring additional clinical hours. Those who have completed a master's degree can advance quickly with a 1 year msn to dnp program to achieve a doctoral degree efficiently.

If you are looking to enter the healthcare field fast, fast medical assistant programs let you qualify for entry-level roles in just a few weeks. There are also online dnp programs without clinicals, making it easier for busy professionals to earn an advanced degree remotely.

Each of these programs can serve as a stepping stone toward specialized genetics or research positions, giving you versatile options as you plan your career path in the USA.

Best Scientists Citing David C. Wedge

Trending Scientists