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Genetics

D-Index
79
Citations
82681
World Ranking
1600
National Ranking
205

Overview

Adam Butler is affiliated with the Wellcome Sanger Institute in the United Kingdom. Their research focuses primarily on biochemistry, genetics, and molecular biology, with additional contributions to medicine. Butler's work spans multiple subfields including molecular biology, genetics, cancer research, pulmonary and respiratory medicine, and pathology and forensic medicine.

They have worked extensively on topics related to cancer genomics and diagnostics, genomics and phylogenetic studies, CRISPR and genetic engineering, prostate cancer treatment and research, chromosomal and genetic variations, evolution and genetic dynamics, and chronic lymphocytic leukemia research.

Their recent publications include:

  • Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition (2020, Nature Genetics)
  • Convergent somatic mutations in metabolism genes in chronic liver disease (2021, Nature)
  • Unified classification and risk-stratification in Acute Myeloid Leukemia (2022, Nature Communications)
  • Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture (2021, Nature Communications)
  • Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020, Nature Communications)

Butler frequently publishes in venues such as Nature Communications, Nature Biotechnology, Nature Genetics, Bioinformatics, and bioRxiv (Cold Spring Harbor Laboratory). Their collaboration network includes frequent co-authors like Peter J. Campbell, Keiran Raine, Julian M. Hess, Roland Eils, and Jonas Demeulemeester.

Best Publications

  • Signatures of mutational processes in human cancer

    Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio

  • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

    Marco Gerlinger;Andrew J. Rowan;Stuart Horswell;James Larkin

  • Genomic Classification and Prognosis in Acute Myeloid Leukemia

    Elli Papaemmanuil;Moritz Gerstung;Lars Bullinger;Verena I Gaidzik

  • Patterns of somatic mutation in human cancer genomes

    Christopher Greenman;Philip Stephens;Raffaella Smith;Gillian L. Dalgliesh

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Systematic identification of genomic markers of drug sensitivity in cancer cells

    Mathew J. Garnett;Elena J. Edelman;Sonja J. Heidorn;Christopher Greenman;Christopher Greenman

  • Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

    Philip J. Stephens;Chris D. Greenman;Beiyuan Fu;Fengtang Yang

  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences

    Serena Nik-Zainal;Serena Nik-Zainal;Helen Davies;Johan Staaf;Manasa Ramakrishna

  • Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

    J. Nangalia;C.E. Massie;E.J. Baxter;F.L. Nice

  • Mutational Processes Molding the Genomes of 21 Breast Cancers

    Serena Nik-Zainal;Ludmil B. Alexandrov;David C. Wedge;Peter Van Loo;Peter Van Loo;Peter Van Loo

  • A comprehensive catalogue of somatic mutations from a human cancer genome

    Erin D. Pleasance;R. Keira Cheetham;Philip J. Stephens;David J. Mcbride

  • Clinical and biological implications of driver mutations in myelodysplastic syndromes.

    Elli Papaemmanuil;Moritz Gerstung;Luca Malcovati;Sudhir Tauro

  • The landscape of cancer genes and mutational processes in breast cancer

    Philip J. Stephens;Patrick S. Tarpey;Helen Davies;Peter Van Loo;Peter Van Loo

  • Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma

    Ignacio Varela;Patrick Tarpey;Keiran Raine;Dachuan Huang

  • The Life History of 21 Breast Cancers

    Serena Nik-Zainal;Peter Van Loo;Peter Van Loo;Peter Van Loo;David C. Wedge;Ludmil B. Alexandrov

  • The patterns and dynamics of genomic instability in metastatic pancreatic cancer

    Peter J. Campbell;Peter J. Campbell;Shinichi Yachida;Laura J. Mudie;Philip J. Stephens

  • Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts

    E. Papaemmanuil;M. Cazzola;J. Boultwood;L. Malcovati

  • A gene map of the human genome

    G. D. Schuler;M. S. Boguski;E. A. Stewart;L. D. Stein

  • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

    Gillian L. Dalgliesh;Kyle Furge;Chris Greenman;Lina Chen

  • A small-cell lung cancer genome with complex signatures of tobacco exposure

    Erin D. Pleasance;Philip J. Stephens;Sarah O’Meara;Sarah O’Meara;David J. McBride

Frequent Co-Authors

Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Jon W. Teague
Jon W. Teague Wellcome Sanger Institute
Keiran Raine
Keiran Raine Wellcome Sanger Institute
Andrew Menzies
Andrew Menzies Wellcome Sanger Institute
Peter Van Loo
Peter Van Loo The Francis Crick Institute
Serena Nik-Zainal
Serena Nik-Zainal University of Cambridge
Graham R. Bignell
Graham R. Bignell Wellcome Sanger Institute
David T. Jones
David T. Jones University College London
Patrick S. Tarpey
Patrick S. Tarpey Wellcome Sanger Institute

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