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Genetics

D-Index
72
Citations
39438
World Ranking
2084
National Ranking
258

Overview

Patrick S. Tarpey is affiliated with the Wellcome Sanger Institute in the United Kingdom. Their research spans multiple fields, primarily focusing on Medicine, with 39 publications, and Biochemistry, Genetics and Molecular Biology, evidenced by 24 publications. Within these domains, their work notably concentrates on Molecular Biology, Cancer Research, Oncology, Pathology and Forensic Medicine, and Genetics.

Tarpey's research topics prominently include Cancer Genomics and Diagnostics, Genetic factors in colorectal cancer, Sarcoma Diagnosis and Treatment, Pancreatic and Hepatic Oncology Research, Genomics and Rare Diseases, Glioma Diagnosis and Treatment, and Renal and related cancers.

They have contributed to several publication venues with multiple works, including Pediatric Blood & Cancer, UNC Libraries, Cancer Research, British Journal of Cancer, and Neuropathology and Applied Neurobiology.

Among recent papers authored or coauthored by Tarpey are:

  • The mutational landscape of normal human endometrial epithelium (2020, Nature)
  • The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer (2022, British Journal of Cancer)
  • Benefits for children with suspected cancer from routine whole-genome sequencing (2024, Nature Medicine)
  • A rare case of paediatric astroblastoma with concomitant MN1-GTSE1 and EWSR1-PATZ1 gene fusions altering management (2021, Neuropathology and Applied Neurobiology)
  • Embryonal tumor with multilayered rosettes: Overview of diagnosis and therapy (2023, Neuro-Oncology Advances)

Frequent coauthors collaborating with Tarpey include Jamie Trotman, Matthew J. Murray, James Watkins, Sam Behjati, and John A. Tadross, reflecting ongoing partnerships within their research projects.

Best Publications

  • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

    Marco Gerlinger;Andrew J. Rowan;Stuart Horswell;James Larkin

  • Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

    J. Nangalia;C.E. Massie;E.J. Baxter;F.L. Nice

  • Mutational Processes Molding the Genomes of 21 Breast Cancers

    Serena Nik-Zainal;Ludmil B. Alexandrov;David C. Wedge;Peter Van Loo;Peter Van Loo;Peter Van Loo

  • The landscape of cancer genes and mutational processes in breast cancer

    Philip J. Stephens;Patrick S. Tarpey;Helen Davies;Peter Van Loo;Peter Van Loo

  • Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma

    Ignacio Varela;Patrick Tarpey;Keiran Raine;Dachuan Huang

  • The Life History of 21 Breast Cancers

    Serena Nik-Zainal;Peter Van Loo;Peter Van Loo;Peter Van Loo;David C. Wedge;Ludmil B. Alexandrov

  • Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts

    E. Papaemmanuil;M. Cazzola;J. Boultwood;L. Malcovati

  • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

    Gillian L. Dalgliesh;Kyle Furge;Chris Greenman;Lina Chen

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

    Gijs Van Haaften;Gillian L Dalgliesh;Helen Davies;Lina Chen

  • Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

    Sam Behjati;Sam Behjati;Patrick S Tarpey;Nadège Presneau;Susanne Scheipl;Susanne Scheipl

  • What is next generation sequencing

    Sam Behjati;Patrick S Tarpey

  • A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

    Patrick S Tarpey;Raffaella Smith;Erin Pleasance;Annabel Whibley

  • Integrative Molecular Characterization of Malignant Pleural Mesothelioma

    Julija Hmeljak;Francisco Sanchez-Vega;Katherine A. Hoadley;Juliann Shih

  • Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

    Thomas J. Mitchell;Samra Turajlic;Andrew Rowan;David Nicol

  • X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment.

    Leanne M. Dibbens;Leanne M. Dibbens;Patrick S. Tarpey;Kim Hynes;Kim Hynes;Marta A. Bayly

  • Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

    Jose M. C. Tubio;Yilong Li;Young Seok Ju;Inigo Martincorena

  • Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

    Y S Ju;L B Alexandrov;M Gerstung;I Martincorena

  • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

    Philip Stephens;Sarah Edkins;Helen Davies;Christopher Greenman

  • The mutational landscape of normal human endometrial epithelium

    Luiza Moore;Luiza Moore;Daniel Leongamornlert;Tim H. H. Coorens;Mathijs A. Sanders;Mathijs A. Sanders

Frequent Co-Authors

Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Jozef Gecz
Jozef Gecz University of Adelaide
Jon W. Teague
Jon W. Teague Wellcome Sanger Institute
Peter Van Loo
Peter Van Loo The Francis Crick Institute
Helen Davies
Helen Davies University of Cambridge
Adrienne M. Flanagan
Adrienne M. Flanagan University College London
Keiran Raine
Keiran Raine Wellcome Sanger Institute
David C. Wedge
David C. Wedge University of Manchester
Charles E. Schwartz
Charles E. Schwartz Greenwood Genetic Center

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