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Biology and Biochemistry

D-Index
64
Citations
65341
World Ranking
9423
National Ranking
717

Overview

Helen Davies is affiliated with the University of Cambridge in the United Kingdom. Their research largely focuses on the fields of Biochemistry, Genetics and Molecular Biology, with significant overlap in Medicine. Their work spans several subfields, notably Cancer Research, Molecular Biology, Oncology, Genetics, and Pulmonary and Respiratory Medicine.

The principal topics Helen Davies has contributed to include:

  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Genetic factors in colorectal cancer
  • PARP inhibition in cancer therapy
  • BRCA gene mutations in cancer
  • Breast Cancer Treatment Studies
  • Molecular Biology Techniques and Applications

Recent publications highlight a focus on mutational signatures, homologous recombination deficiency, and breast cancer genomics. Key recent papers include:

  • "A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies" (2020, Nature Cancer)
  • "Substitution mutational signatures in whole-genome-sequenced cancers in the UK population" (2022, Science)
  • "Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer" (2020, Nature Communications)
  • "Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer" (2022, Nature Genetics)
  • "Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests" (2022, Oncogene)

Helen Davies frequently collaborates with several researchers, including:

  • Serena Nik-Zainal
  • Yasin Memari
  • Andrea Degasperi
  • Esther H. Lips
  • Lodewyk F.A. Wessels

Their publications have appeared most often in the following venues:

  • Cancer Research
  • Nature Communications
  • Annals of Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cancer

Best Publications

  • Mutations of the BRAF gene in human cancer

    Helen Davies;Graham R. Bignell;Charles Cox;Philip Stephens

  • Signatures of mutational processes in human cancer

    Ludmil B. Alexandrov;Serena Nik-Zainal;Serena Nik-Zainal;David C. Wedge;Samuel A. J. R. Aparicio

  • Patterns of somatic mutation in human cancer genomes

    Christopher Greenman;Philip Stephens;Raffaella Smith;Gillian L. Dalgliesh

  • Systematic identification of genomic markers of drug sensitivity in cancer cells

    Mathew J. Garnett;Elena J. Edelman;Sonja J. Heidorn;Christopher Greenman;Christopher Greenman

  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences

    Serena Nik-Zainal;Serena Nik-Zainal;Helen Davies;Johan Staaf;Manasa Ramakrishna

  • Mutational Processes Molding the Genomes of 21 Breast Cancers

    Serena Nik-Zainal;Ludmil B. Alexandrov;David C. Wedge;Peter Van Loo;Peter Van Loo;Peter Van Loo

  • The landscape of cancer genes and mutational processes in breast cancer

    Philip J. Stephens;Patrick S. Tarpey;Helen Davies;Peter Van Loo;Peter Van Loo

  • Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma

    Ignacio Varela;Patrick Tarpey;Keiran Raine;Dachuan Huang

  • The Life History of 21 Breast Cancers

    Serena Nik-Zainal;Peter Van Loo;Peter Van Loo;Peter Van Loo;David C. Wedge;Ludmil B. Alexandrov

  • Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts

    E. Papaemmanuil;M. Cazzola;J. Boultwood;L. Malcovati

  • BRAF and RAS mutations in human lung cancer and melanoma

    Marcia S. Brose;Patricia Volpe;Michael Feldman;Madhu Kumar

  • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

    Gillian L. Dalgliesh;Kyle Furge;Chris Greenman;Lina Chen

  • Universal Patterns of Selection in Cancer and Somatic Tissues

    Iñigo Martincorena;Keiran M. Raine;Moritz Gerstung;Kevin J. Dawson

  • A small-cell lung cancer genome with complex signatures of tobacco exposure

    Erin D. Pleasance;Philip J. Stephens;Sarah O’Meara;Sarah O’Meara;David J. McBride

  • HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

    Helen Davies;Dominik D. Glodzik;Sandro S. Morganella;Lucy R. Yates

  • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

    Gijs Van Haaften;Gillian L Dalgliesh;Helen Davies;Lina Chen

  • Signatures of mutation and selection in the cancer genome

    Graham R. Bignell;Chris D. Greenman;Helen Davies;Adam P. Butler

  • Subclonal diversification of primary breast cancer revealed by multiregion sequencing

    Lucy R. Yates;Moritz Gerstung;Stian Knappskog;Christine Desmedt

  • Lung cancer: intragenic ERBB2 kinase mutations in tumours.

    Philip Stephens;Chris Hunter;Graham Bignell;Sarah Edkins

  • Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

    Sam Behjati;Sam Behjati;Patrick S Tarpey;Nadège Presneau;Susanne Scheipl;Susanne Scheipl

Frequent Co-Authors

Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Serena Nik-Zainal
Serena Nik-Zainal University of Cambridge
Adam Butler
Adam Butler Wellcome Sanger Institute
P. Andrew Futreal
P. Andrew Futreal The University of Texas MD Anderson Cancer Center
Jon W. Teague
Jon W. Teague Wellcome Sanger Institute
Keiran Raine
Keiran Raine Wellcome Sanger Institute
Patrick S. Tarpey
Patrick S. Tarpey Wellcome Sanger Institute
Graham R. Bignell
Graham R. Bignell Wellcome Sanger Institute
Anne Lise Børresen-Dale
Anne Lise Børresen-Dale Oslo University Hospital

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