Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.
Stefan G. Sarafianos;Bruno Marchand;Kalyan Das;Daniel M. Himmel.
Journal of Molecular Biology (2009)
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
Stefan G. Sarafianos;Kalyan Das;Chris Tantillo;Arthur D. Clark.
The EMBO Journal (2001)
Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants
Kalyan Das;Arthur D. Clark;Paul J. Lewi;Jan Heeres.
Journal of Medicinal Chemistry (2004)
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
Paul A. J. Janssen;Paul J. Lewi;Eddy Arnold;Frits Daeyaert.
Journal of Medicinal Chemistry (2005)
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
Jianping Ding;Kalyan Das;Henri Moereels;Luc Koymans.
Nature Structural & Molecular Biology (1995)
Structures of influenza A proteins and insights into antiviral drug targets
Kalyan Das;James M. Aramini;James M. Aramini;Li Chung Ma;Li Chung Ma;Robert M. Krug.
Nature Structural & Molecular Biology (2010)
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.
Y. Hsiou;J. Ding;K. Das;A. D. Clark.
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids
Stefan G. Sarafianos;Kalyan Das;Arthur D. Clark;Jianping Ding.
Proceedings of the National Academy of Sciences of the United States of America (1999)
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.
Kalyan Das;Joseph D. Bauman;Arthur D. Clark;Yulia V. Frenkel.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Donald W. Ludovici;Bart L. De Corte;Michael J. Kukla;Hong Ye.
Bioorganic & Medicinal Chemistry Letters (2001)
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