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Biology and Biochemistry

D-Index
62
Citations
14380
World Ranking
10753
National Ranking
194

Overview

Kalyan Das is affiliated with the Rega Institute for Medical Research in Belgium. Their research spans several domains within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and infectious diseases. Their work frequently addresses mechanisms involved in RNA and protein synthesis, HIV/AIDS drug development and treatment, RNA modifications related to cancer, and other areas such as RNA research and splicing, cytomegalovirus and herpesvirus research, and DNA and nucleic acid chemistry.

Das has contributed significantly to research published in a variety of scientific venues. Their most frequent publication platforms include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Journal of Medicinal Chemistry, Journal of Biological Chemistry, and Viruses.

Recent notable papers authored by or involving Kalyan Das include:

  • Structure, mechanism, and regulation of mitochondrial DNA transcription initiation (2020), Journal of Biological Chemistry
  • Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies (2022), Viruses
  • Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative (2023), Science Advances
  • The dynamic landscape of transcription initiation in yeast mitochondria (2020), Nature Communications
  • Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase (2020), Molecular Cell

Das regularly collaborates with several co-authors in their research efforts. Frequent collaborators include Brent De Wijngaert, Sergio E. Martinez, Smita S. Patel, Abhimanyu K. Singh, and Jiayu Shen.

The main fields of study for Das encompass:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, the subfields of focus include:

  • Molecular Biology
  • Infectious Diseases
  • Virology
  • Epidemiology
  • Cardiology and Cardiovascular Medicine

Their work covers substantial topics such as:

  • RNA and protein synthesis mechanisms
  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Cytomegalovirus and herpesvirus research
  • DNA and Nucleic Acid Chemistry

Best Publications

  • Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

    Stefan G. Sarafianos;Bruno Marchand;Kalyan Das;Daniel M. Himmel

  • Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

    Kalyan Das;Arthur D. Clark;Paul J. Lewi;Jan Heeres

  • Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.

    Stefan G. Sarafianos;Kalyan Das;Chris Tantillo;Arthur D. Clark

  • In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

    Paul A. J. Janssen;Paul J. Lewi;Eddy Arnold;Frits Daeyaert

  • Structures of influenza A proteins and insights into antiviral drug targets

    Kalyan Das;James M. Aramini;James M. Aramini;Li Chung Ma;Li Chung Ma;Robert M. Krug

  • Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

    Jianping Ding;Kalyan Das;Henri Moereels;Luc Koymans

  • High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.

    Kalyan Das;Joseph D. Bauman;Arthur D. Clark;Yulia V. Frenkel

  • Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.

    Y. Hsiou;J. Ding;K. Das;A. D. Clark

  • Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

    Stefan G. Sarafianos;Kalyan Das;Arthur D. Clark;Jianping Ding

  • Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.

    Donald W. Ludovici;Bart L. De Corte;Michael J. Kukla;Hong Ye

  • Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.

    Jianping Ding;Kalyan Das;Yu Hsiou;Stefan G Sarafianos

  • The Hepatitis B Virus Polymerase Mutation rtV173L Is Selected during Lamivudine Therapy and Enhances Viral Replication In Vitro

    William E. Delaney;Huiling Yang;Christopher E. Westland;Kalyan Das;Kalyan Das

  • Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)

    Kalyan Das;Xiaofeng Xiong;Huiling Yang;Christopher E. Westland

  • Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.

    Kalyan Das;Jianping Ding;Yu Hsiou;Arthur D. Clark

  • Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

    Kalyan Das;Paul J. Lewi;Stephen H. Hughes;Eddy Arnold

  • Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

    J Ding;K Das;C Tantillo;W Zhang

  • The RNA Polymerase “Switch Region” Is a Target for Inhibitors

    Jayanta Mukhopadhyay;Kalyan Das;Kalyan Das;Sajida Ismail;Sajida Ismail;David Koppstein;David Koppstein

  • Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

    Stefan G. Sarafianos;Arthur D. Clark;Kalyan Das;Steve Tuske

  • Structural basis for suppression of a host antiviral response by influenza A virus.

    Kalyan Das;Li Chung Ma;Rong Xiao;Brian Radvansky

  • The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.

    Yu Hsiou;Jianping Ding;Jianping Ding;Kalyan Das;Arthur D Clark

Frequent Co-Authors

Eddy Arnold
Eddy Arnold Rutgers, The State University of New Jersey
Stephen Hughes
Stephen Hughes National Cancer Institute
Stefan G. Sarafianos
Stefan G. Sarafianos University of Missouri
Jianping Ding
Jianping Ding Chinese Academy of Sciences
Harkesh B. Singh
Harkesh B. Singh Indian Institute of Technology Bombay
Richard H. Ebright
Richard H. Ebright Rutgers, The State University of New Jersey
Gaetano T. Montelione
Gaetano T. Montelione Rensselaer Polytechnic Institute
Aaron J. Shatkin
Aaron J. Shatkin Rutgers, The State University of New Jersey
Jan Balzarini
Jan Balzarini KU Leuven

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