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D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
21830
World Ranking
4104
National Ranking
2017

Overview

Eddy Arnold is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Subfields of particular focus include Infectious Diseases, Molecular Biology, Virology, Epidemiology, and Materials Chemistry.

The researcher's work addresses multiple topics within these domains, notably:

  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • SARS-CoV-2 and COVID-19 Research
  • Enzyme Structure and Function
  • Vaccines and immunoinformatics approaches
  • HIV/AIDS Research and Interventions
  • Viral gastroenteritis research and epidemiology

Eddy Arnold has contributed to several recent publications, including the following notable papers:

  • Structures, functions and adaptations of the human LINE-1 ORF2 protein, 2023, published in Nature
  • Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance, 2020, published in Current Opinion in Structural Biology
  • Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model, 2024, published in Science
  • 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies, 2021, published in Journal of Medicinal Chemistry
  • Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first 6 months of the COVID-19 pandemic, 2021, published in Proteins Structure Function and Bioinformatics

Frequent coauthors collaborating with Eddy Arnold include:

  • Francesc X. Ruiz
  • Joseph D. Bauman
  • Ashima Chopra
  • Patrick R. Griffin
  • Kalyan Das

Key publication venues for Eddy Arnold reflect a diverse range of journals and repositories, such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Zenodo (CERN European Organization for Nuclear Research)
  • Proceedings of the National Academy of Sciences
  • Science Advances

The concentration of Eddy Arnold's work in disciplines related to infectious diseases and molecular biology, combined with their focus on viral pathogens such as HIV and SARS-CoV-2, aligns with ongoing research efforts in antiviral drug development, structural biology, and epidemiological studies.

Best Publications

  • Structure of a human common cold virus and functional relationship to other picornaviruses

    Michael G. Rossmann;Edward Arnold;John W. Erickson;Elizabeth A. Frankenberger

  • Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

    Stefan G. Sarafianos;Bruno Marchand;Kalyan Das;Daniel M. Himmel

  • Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

    Kalyan Das;Arthur D. Clark;Paul J. Lewi;Jan Heeres

  • Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.

    Stefan G. Sarafianos;Kalyan Das;Chris Tantillo;Arthur D. Clark

  • In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

    Paul A. J. Janssen;Paul J. Lewi;Eddy Arnold;Frits Daeyaert

  • Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

    T Shirasaka;M F Kavlick;T Ueno;W Y Gao

  • Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

    Xiang Xu;Jingyue Zhao;Zhen Xu;Baozhen Peng

  • Structures of influenza A proteins and insights into antiviral drug targets

    Kalyan Das;James M. Aramini;James M. Aramini;Li Chung Ma;Li Chung Ma;Robert M. Krug

  • Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

    Jianping Ding;Kalyan Das;Henri Moereels;Luc Koymans

  • High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.

    Kalyan Das;Joseph D. Bauman;Arthur D. Clark;Yulia V. Frenkel

  • Structural basis of transcription initiation.

    Yu Zhang;Yu Feng;Sujoy Chatterjee;Steve Tuske

  • Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.

    Jianping Ding;Kalyan Das;Yu Hsiou;Stefan G Sarafianos

  • The Hepatitis B Virus Polymerase Mutation rtV173L Is Selected during Lamivudine Therapy and Enhances Viral Replication In Vitro

    William E. Delaney;Huiling Yang;Christopher E. Westland;Kalyan Das;Kalyan Das

  • Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

    Kalyan Das;Paul J. Lewi;Stephen H. Hughes;Eddy Arnold

  • Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

    J Ding;K Das;C Tantillo;W Zhang

  • The RNA Polymerase “Switch Region” Is a Target for Inhibitors

    Jayanta Mukhopadhyay;Kalyan Das;Kalyan Das;Sajida Ismail;Sajida Ismail;David Koppstein;David Koppstein

  • Implications of the picornavirus capsid structure for polyprotein processing.

    Edward Arnold;Ming Luo;Gerrit Vriend;Michael G. Rossmann

  • Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation

    Steven Tuske;Steven Tuske;Stefan G. Sarafianos;Stefan G. Sarafianos;Xinyue Wang;Xinyue Wang;Brian Hudson;Brian Hudson

  • Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

    Stefan G. Sarafianos;Arthur D. Clark;Kalyan Das;Steve Tuske

  • Structural basis for suppression of a host antiviral response by influenza A virus.

    Kalyan Das;Li Chung Ma;Rong Xiao;Brian Radvansky

Frequent Co-Authors

Kalyan Das
Kalyan Das Rega Institute for Medical Research
Stefan G. Sarafianos
Stefan G. Sarafianos University of Missouri
Stephen Hughes
Stephen Hughes National Cancer Institute
Jianping Ding
Jianping Ding Chinese Academy of Sciences
Ronald M. Levy
Ronald M. Levy Temple University
Richard H. Ebright
Richard H. Ebright Rutgers, The State University of New Jersey
Edmond J. LaVoie
Edmond J. LaVoie Rutgers, The State University of New Jersey
Emilio Gallicchio
Emilio Gallicchio City University of New York
Aaron J. Shatkin
Aaron J. Shatkin Rutgers, The State University of New Jersey

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