World's Best Scientists 2026 revealed!
Hiroaki Mitsuya

Hiroaki Mitsuya

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Microbiology
Japan
2026

D-Index & Metrics

Microbiology

D-Index
103
Citations
44645
World Ranking
344
National Ranking
7

Medicine

D-Index
103
Citations
45656
World Ranking
7275
National Ranking
172

Research.com Recognitions

  • 2026 - Research.com Microbiology in Japan Leader Award
  • 2025 - Research.com Microbiology in Japan Leader Award
  • 2023 - Research.com Microbiology in Japan Leader Award
  • 2022 - Research.com Microbiology in Japan Leader Award
  • 2007 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Hiroaki Mitsuya is affiliated with Kumamoto University in Japan. Their research focuses primarily on the field of Medicine, with a specialization in Infectious Diseases, Epidemiology, Virology, Immunology, and Molecular Biology.

The scientist's work extensively covers topics related to SARS-CoV-2 and COVID-19 research, including clinical research studies on COVID-19, detection and testing methods, as well as research on HIV/AIDS drug development and treatment, Hepatitis B and C virus studies. The main topics of their research include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • Hepatitis B Virus Studies
  • SARS-CoV-2 detection and testing
  • Hepatitis C virus research

The scientist has published numerous papers, some of the recent notable publications are:

  • "Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development" (2020) in Proceedings of the National Academy of Sciences
  • "Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2" (2022) in Nature
  • "Comparison of Rapid Antigen Tests for COVID-19" (2020) in Viruses
  • "A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication" (2021) in Nature Communications
  • "Antibody titers against SARS-CoV-2 decline, but do not disappear for several months" (2021) in EClinicalMedicine

Frequent co-authors who have collaborated with the scientist include:

  • Kenji Maeda
  • Norio Ohmagari
  • Yuki Takamatsu
  • Nobuyo Higashi-Kuwata
  • Kouki Matsuda

Publications are often found in the following venues:

  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • Journal of Infection and Chemotherapy
  • Global Health & Medicine

The scientist has been recognized through awards such as the Keio Medical Science Prize from Keio University, Tokyo, Japan in 2007 and membership in the Association of American Physicians.

Best Publications

  • 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

    H Mitsuya;K J Weinhold;P A Furman;M H St Clair

  • Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

    P A Furman;J A Fyfe;M H St Clair;K Weinhold

  • Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

    Hiroaki Mitsuya;Samuel Broder

  • Molecular targets for AIDS therapy

    Hiroaki Mitsuya;Robert Yarchoan;Samuel Broder

  • Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.

    Masaki Imai;Kiyoko Iwatsuki-Horimoto;Masato Hatta;Samantha Loeber

  • ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

    Robert Yarchoan;Kent J. Weinhold;H. Kim Lyerly;Edward Gelmann

  • Designing CD4 immunoadhesins for AIDS therapy

    Daniel J. Capon;Steven M. Chamow;Joyce Mordenti;Scot A. Marsters

  • Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

    Makoto Matsukura;Kazuo Shinozuka;Gerald Zon;Hiroaki Mitsuya

  • Strategies for antiviral therapy in AIDS.

    Hiroaki Mitsuya;Samuel Broder

  • Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells

    Hiroaki Mitsuya;David J. Looney;Sachiko Kuno;Ryuji Ueno

  • PHASE I STUDIES OF 2',3'-DIDEOXYCYTIDINE IN SEVERE HUMAN IMMUNODEFICIENCY VIRUS INFECTION AS A SINGLE AGENT AND ALTERNATING WITH ZIDOVUDINE (AZT)

    Robert Yarchoan;Rose V. Thomas;Jean Pierre Allain;Nanette Mcatee

  • In vivo activity against HIV and favorable toxicity profile of 2',3'-dideoxyinosine

    Robert Yarchoan;Hiroaki Mitsuya;Rose V. Thomas;James M. Pluda

  • Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III.

    Hiroaki Mitsuya;Mikulas Popovic;Robert Yarchoan;Shuzo Matsushita

  • Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro

    Yasuhiro Koh;Hirotomo Nakata;Kenji Maeda;Hiromi Ogata

  • Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.

    Robert Yarchoan;Hiroaki Mitsuya;Charles E. Myers;Samuel Broder

  • Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity

    David A. Cooney;Maha Dalal;Hiroaki Mitsuya;James B. McMahon

  • Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology

    Richard F. Little;Stefania Pittaluga;Nicole Grant;Seth M. Steinberg

  • Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

    C.-F. Perno;R. Yarchoan;D. A. Cooney;N. R. Hartman

  • Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure.

    Sergei V. Gulnik;Leonid I. Suvorov;Beishan Liu;Betty Yu

  • Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

    Makoto Matsukura;Gerald Zon;Kazuo Shinozuka;Marjorie Robert-Guroff

Frequent Co-Authors

Arun K. Ghosh
Arun K. Ghosh Purdue University West Lafayette
Samuel Broder
Samuel Broder Precision BioSciences
Robert Yarchoan
Robert Yarchoan National Institutes of Health
Masao Matsuoka
Masao Matsuoka Kumamoto University
Irene T. Weber
Irene T. Weber Georgia State University
David G. Johns
David G. Johns National Institutes of Health
Kazuhisa Yoshimura
Kazuhisa Yoshimura National Institutes of Health
Hiroyuki Gatanaga
Hiroyuki Gatanaga Kumamoto University
Victor E. Marquez
Victor E. Marquez National Institutes of Health
Stefan G. Sarafianos
Stefan G. Sarafianos University of Missouri

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