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Genetics

D-Index
57
Citations
79853
World Ranking
3345
National Ranking
1449

Overview

David E. Larson is affiliated with Washington University in St. Louis in the United States. Their research predominantly falls within the field of Biochemistry, Genetics, and Molecular Biology, with a focus on several specialized subfields such as Molecular Biology, Genetics, Cancer Research, Artificial Intelligence, and Pathology and Forensic Medicine.

Larson's recent scholarly contributions encompass a variety of topics central to genomics and molecular biology. Their main topics of work include:

  • Cancer Genomics and Diagnostics
  • Genomics and Phylogenetic Studies
  • Genomic Variations and Chromosomal Abnormalities
  • Genetic Associations and Epidemiology
  • Genomics and Rare Diseases
  • RNA Modifications and Cancer
  • Mitochondrial Function and Pathology

Their research has been published in several notable venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nature
  • The Journal of Open Source Software
  • Science Advances

Frequent collaboration is a feature of Larson's work, with regular coauthors being Haley Abel, Allison Regier, Indraniel Das, Krishna Kanchi, and Nathan O. Stitziel.

Among notable recent papers authored or coauthored by Larson are:

  • Mapping and characterization of structural variation in 17,795 human genomes (2020, Nature)
  • Bam-readcount - rapid generation of basepair-resolution sequence metrics (2022, The Journal of Open Source Software)
  • The clonal evolution of metastatic colorectal cancer (2020, Science Advances)
  • Association of structural variation with cardiometabolic traits in Finns (2021, The American Journal of Human Genetics)
  • Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences (2021, Human Genomics)

Best Publications

  • A global reference for human genetic variation.

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

  • The cancer genome atlas pan-cancer analysis project

    John N Weinstein;John N Weinstein;Eric A. Collisson;Gordon B Mills;Kenna R Mills Shaw;Kenna R Mills Shaw

  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways

    Roger McLendon;Allan Friedman;Darrell Bigner;Erwin G. Van Meir

  • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

    Timothy J. Ley;Christopher Miller;Li Ding;Benjamin J. Raphael

  • VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

    Daniel C. Koboldt;Qunyuan Zhang;David E. Larson;Dong Shen

  • Somatic mutations affect key pathways in lung adenocarcinoma

    Li Ding;Gad Getz;David A. Wheeler;Elaine R. Mardis

  • Recurring mutations found by sequencing an acute myeloid leukemia genome.

    Elaine R. Mardis;Li Ding;David J. Dooling;David E. Larson

  • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

    Li Ding;Timothy J. Ley;David E. Larson;Christopher A. Miller

  • DNMT3A Mutations in Acute Myeloid Leukemia

    Timothy J. Ley;Li Ding;Matthew J. Walter;Michael D. McLellan

  • The origin and evolution of mutations in acute myeloid leukemia.

    John S. Welch;Timothy J. Ley;Daniel C. Link;Christopher A. Miller

  • BreakDancer: An algorithm for high resolution mapping of genomic structural variation

    Ken Chen;John W Wallis;Michael D McLellan;David E Larson

  • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

    Timothy J. Ley;Elaine R. Mardis;Li Ding;Bob Fulton

  • VarScan: Variant detection in massively parallel sequencing of individual and pooled samples

    Daniel C. Koboldt;Ken Chen;Todd Wylie;David E. Larson

  • Genome remodelling in a basal-like breast cancer metastasis and xenograft

    Li Ding;Matthew J C Ellis;Shunqiang Li;David E. Larson

  • The Next-Generation Sequencing Revolution and Its Impact on Genomics

    Daniel C. Koboldt;Karyn Meltz Steinberg;David E. Larson;Richard K. Wilson

  • A global reference for human genetic variation

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

  • Clonal Architecture of Secondary Acute Myeloid Leukemia

    Matthew J. Walter;Dong Shen;Li Ding;Jin Shao

  • SomaticSniper: identification of somatic point mutations in whole genome sequencing data

    David E. Larson;Christopher C. Harris;Ken Chen;Daniel C. Koboldt

  • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

    Timothy A Graubert;Dong Shen;Li Ding;Theresa Okeyo-Owuor

  • The Cancer Genome Atlas Pan-Cancer analysis project

    Kyle Chang;Chad J Creighton;Caleb Davis;Lawrence Donehower

Frequent Co-Authors

Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital
Robert S. Fulton
Robert S. Fulton Washington University in St. Louis
Daniel C. Koboldt
Daniel C. Koboldt The Ohio State University
Li Ding
Li Ding Washington University in St. Louis
Timothy J. Ley
Timothy J. Ley Washington University in St. Louis
Michael D. McLellan
Michael D. McLellan Washington University in St. Louis
Vincent Magrini
Vincent Magrini The Ohio State University
Malachi Griffith
Malachi Griffith Washington University in St. Louis
Ken Chen
Ken Chen The University of Texas MD Anderson Cancer Center

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