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Genetics

D-Index
85
Citations
54792
World Ranking
1277
National Ranking
607

Overview

Ken Chen is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans fields primarily in Biochemistry, Genetics and Molecular Biology, as well as Medicine. The principal subfields they work within include Molecular Biology, Immunology, Oncology, Cancer Research, and Pulmonary and Respiratory Medicine.

Their research interests focus on several key areas including:

  • Single-cell and spatial transcriptomics
  • Cancer Genomics and Diagnostics
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Immune cells in cancer
  • Acute Myeloid Leukemia Research

Recent publications by Ken Chen include:

  • Patterns of somatic structural variation in human cancer genomes (2020, Nature)
  • Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes (2021, Nature Biotechnology)
  • Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing (2020, Nature Genetics)
  • A robust benchmark for detection of germline large deletions and insertions (2020, Nature Biotechnology)
  • Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition (2020, Nature Genetics)

Ken Chen frequently collaborates with a number of co-authors, including:

  • Vakul Mohanty
  • Jinzhuang Dou
  • Katayoun Rezvani
  • Rafet Başar
  • Shaoheng Liang

Their work is published regularly in key scientific venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Blood
  • Regular and Young Investigator Award Abstracts

Best Publications

  • A global reference for human genetic variation.

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways

    Roger McLendon;Allan Friedman;Darrell Bigner;Erwin G. Van Meir

  • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

    Timothy J. Ley;Christopher Miller;Li Ding;Benjamin J. Raphael

  • The Immune Landscape of Cancer

    Vésteinn Thorsson;David L Gibbs;Scott D Brown;Denise Wolf

  • Somatic mutations affect key pathways in lung adenocarcinoma

    Li Ding;Gad Getz;David A. Wheeler;Elaine R. Mardis

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Recurring mutations found by sequencing an acute myeloid leukemia genome.

    Elaine R. Mardis;Li Ding;David J. Dooling;David E. Larson

  • Comprehensive Characterization of Cancer Driver Genes and Mutations.

    Matthew H Bailey;Collin Tokheim;Eduard Porta-Pardo;Sohini Sengupta

  • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

    Li Ding;Timothy J. Ley;David E. Larson;Christopher A. Miller

  • An integrated map of structural variation in 2,504 human genomes

    Peter H. Sudmant;Tobias Rausch;Eugene J. Gardner;Robert E. Handsaker;Robert E. Handsaker

  • The origin and evolution of mutations in acute myeloid leukemia.

    John S. Welch;Timothy J. Ley;Daniel C. Link;Christopher A. Miller

  • BreakDancer: An algorithm for high resolution mapping of genomic structural variation

    Ken Chen;John W Wallis;Michael D McLellan;David E Larson

  • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

    Timothy J. Ley;Elaine R. Mardis;Li Ding;Bob Fulton

  • VarScan: Variant detection in massively parallel sequencing of individual and pooled samples

    Daniel C. Koboldt;Ken Chen;Todd Wylie;David E. Larson

  • Mapping copy number variation by population-scale genome sequencing

    Ryan E. Mills;Klaudia Walter;Chip Stewart;Robert E. Handsaker

  • Genome remodelling in a basal-like breast cancer metastasis and xenograft

    Li Ding;Matthew J C Ellis;Shunqiang Li;David E. Larson

  • Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

    Ramaswamy Govindan;Li Ding;Malachi Griffith;Janakiraman Subramanian

  • Whole-genome analysis informs breast cancer response to aromatase inhibition

    Matthew J. Ellis;Li Ding;Dong Shen;Jingqin Luo

  • Clonal evolution in breast cancer revealed by single nucleus genome sequencing

    Yong Wang;Jill Waters;Marco L. Leung;Anna Unruh

  • A global reference for human genetic variation

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

Frequent Co-Authors

Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Li Ding
Li Ding Washington University in St. Louis
Funda Meric-Bernstam
Funda Meric-Bernstam The University of Texas MD Anderson Cancer Center
Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital
Michael D. McLellan
Michael D. McLellan Washington University in St. Louis
Nicholas Navin
Nicholas Navin The University of Texas MD Anderson Cancer Center
Daniel C. Koboldt
Daniel C. Koboldt The Ohio State University
Michael C. Wendl
Michael C. Wendl Washington University in St. Louis
Robert S. Fulton
Robert S. Fulton Washington University in St. Louis

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