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D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
13452
World Ranking
18225
National Ranking
1434

Overview

Olga Perisic is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions also noted in Medicine. Their work covers key subfields such as Molecular Biology, Cell Biology, Genetics, Cancer Research, and Immunology.

Their published research addresses diverse topics including PI3K/AKT/mTOR signaling in cancer, Chronic Lymphocytic Leukemia Research, Immunodeficiency and Autoimmune Disorders, Cellular transport and secretion, CRISPR and Genetic Engineering, Hippo pathway signaling and YAP/TAZ, and Renal and related cancers.

Frequent co-authors in their collaborative work include Roger Williams, Madhanagopal Anandapadamanaban, Yohei Ohashi, Sarah Maslen, and Mark Skehel.

Olga Perisic's recent notable papers are:

  • "Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes" (2021, Nature Communications)
  • "Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress" (2023, Science Advances)
  • "Development of selective inhibitors of phosphatidylinositol 3-kinase C2α" (2022, Nature Chemical Biology)
  • "Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace" (2021, eLife)
  • "Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis" (2024, Oncogene)

Their research has been published frequently in venues such as eLife, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Science Advances, and Nature Chemical Biology.

Best Publications

  • Structural Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

    Edward H. Walker;Michael E. Pacold;Olga Perisic;Len Stephens

  • Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

    Michael E. Pacold;Sabine Suire;Olga Perisic;Samuel Lara-Gonzalez

  • Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.

    Lars-Oliver Essen;Olga Perisic;Robert Cheung;Matilda Katan

  • Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

    Ivan Angulo;Oscar Vadas;Fabien Garçon;Edward Banham-Hall

  • Structural insights into phosphoinositide 3-kinase catalysis and signalling.

    Edward H. Walker;Olga Perisic;Christian Ried;Len Stephens

  • Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit.

    Olga Perisic;Hua Xiao;John T. Lis

  • Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit.

    Nabil Miled;Ying Yan;Wai Ching Hon;Olga Perisic

  • Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

    Dimitrios Karathanassis;Robert V. Stahelin;Jerónimo Bravo;Olga Perisic

  • Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

    Olga Perisic;Sun Fong;Denise E. Lynch;Mark Bycroft

  • Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

    Simon Miller;Brandon Tavshanjian;Arkadiusz Oleksy;Olga Perisic

  • Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit.

    Hua Xiao;Olga Perisic;John T. Lis

  • Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.

    Takayuki Obita;Suraj Saksena;Sara Ghazi-Tabatabai;David J. Gill

  • The Crystal Structure of the Px Domain from P40Phox Bound to Phosphatidylinositol 3-Phosphate

    Jerónimo Bravo;Dimitrios Karathanassis;Christine M Pacold;Michael E Pacold

  • Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)

    John E. Burke;Olga Perisic;Glenn R. Masson;Oscar Vadas

  • ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting: Crystal Structure and Interactions with ESCRT-III and Membranes

    Hsiangling Teo;Olga Perisic;Beatriz González;Roger L. Williams

  • ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

    Hsiangling Teo;David J. Gill;Ji Sun;Olga Perisic

  • Crystal structure of a diabody, a bivalent antibody fragment.

    Olga Perisic;Philip A Webb;Philipp Holliger;Greg Winter

  • PB1 Domain-Mediated Heterodimerization in NADPH Oxidase and Signaling Complexes of Atypical Protein Kinase C with Par6 and p62

    Michael I. Wilson;David J. Gill;Olga Perisic;Mark T. Quinn

  • Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

    Xuxiao Zhang;Oscar Vadas;Olga Perisic;Karen E. Anderson

  • Catalytic Domain of Phosphoinositide-specific Phospholipase C (PLC)

    Moira V. Ellis;Stephen R. James;Olga Perisic;C. Peter Downes

Frequent Co-Authors

Roger L. Williams
Roger L. Williams University of Cambridge
Len R. Stephens
Len R. Stephens Babraham Institute
Phillip T. Hawkins
Phillip T. Hawkins Babraham Institute
Scott D. Emr
Scott D. Emr Cornell University
Dmitry B. Veprintsev
Dmitry B. Veprintsev University of Nottingham
Jolinda A. Traugh
Jolinda A. Traugh University of California, Riverside
Matilda Katan
Matilda Katan University College London
Jan Löwe
Jan Löwe MRC Laboratory of Molecular Biology
Lars-Oliver Essen
Lars-Oliver Essen Philipp University of Marburg
Christopher M. Johnson
Christopher M. Johnson MRC Laboratory of Molecular Biology

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