World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
68
Citations
15394
World Ranking
6578
National Ranking
1991

Biology and Biochemistry

D-Index
69
Citations
15587
World Ranking
7463
National Ranking
3402

Overview

Joseph J. Falke is affiliated with the University of Colorado Boulder in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with notable subfields including Molecular Biology, Cell Biology, Radiology, Nuclear Medicine and Imaging, Immunology and Allergy, and Oncology.

The main topics addressed in Falke's work encompass Protein Kinase Regulation and GTPase Signaling, Cellular transport and secretion, Lipid Membrane Structure and Behavior, PI3K/AKT/mTOR signaling in cancer, Receptor Mechanisms and Signaling, Monoclonal and Polyclonal Antibodies Research, and Cell death mechanisms and regulation.

Falke has contributed to numerous publications, frequently collaborating with coauthors such as Moshe T. Gordon, Brian P. Ziemba, G. Hayden Swisher, Nicholas J. Cordaro, and Annette H. Erbse. Their research has appeared predominantly in the Biophysical Journal and Analytical Biochemistry, with additional works published in bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, and arXiv (Cornell University).

Some of their recent papers include:

  • The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism (2020, Biophysical Journal)
  • Single-molecule studies reveal regulatory interactions between master kinases PDK1, AKT1, and PKC (2021, Biophysical Journal)
  • HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase (2021, Analytical Biochemistry)
  • PDK1:PKCα heterodimer association-dissociation dynamics in single-molecule diffusion tracks on a target membrane (2023, Biophysical Journal)
  • Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements (2022, Analytical Biochemistry)

Best Publications

  • THE C2 DOMAIN CALCIUM-BINDING MOTIF : STRUCTURAL AND FUNCTIONAL DIVERSITY

    Eric A. Nalefski;Joseph J. Falke

  • [16] Purification of proteins using polyhistidine affinity tags

    Joshua A. Bornhorst;Joseph J. Falke

  • Bacterial chemoreceptors: high-performance signaling in networked arrays.

    Gerald L. Hazelbauer;Joseph J. Falke;John S. Parkinson

  • THE TWO-COMPONENT SIGNALING PATHWAY OF BACTERIAL CHEMOTAXIS: A Molecular View of Signal Transduction by Receptors, Kinases, and Adaptation Enzymes

    Joseph J. Falke;Randal B. Bass;Scott L. Butler;Stephen A. Chervitz

  • Evidence that opioids may have toll-like receptor 4 and MD-2 effects

    Mark R. Hutchinson;Yingning Zhang;Mitesh Shridhar;John H. Evans

  • Transmembrane signaling in bacterial chemoreceptors

    Joseph J. Falke;Gerald L. Hazelbauer

  • Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update

    John S. Parkinson;Gerald L. Hazelbauer;Joseph J. Falke

  • Molecular Tuning of Ion Binding to Calcium Signaling Proteins

    Joseph J. Falke;Steven K. Drake;Andrea L. Hazard;Olve B. Peersen

  • Use of 19F NMR to Probe Protein Structure and Conformational Changes

    Mark A. Danielson;Joseph J. Falke

  • Global Flexibility in a Sensory Receptor: a Site-Directed Cross-Linking Approach

    Joseph J. Falke;Daniel E. Koshland

  • Molecular mechanism of transmembrane signaling by the aspartate receptor: a model.

    Stephen A. Chervitz;Joseph J. Falke

  • Thermal Motions of Surface α-Helices in the D-Galactose Chemosensory Receptor: Detection by Disulfide Trapping

    Claire L. Careaga;Joseph J. Falke

  • Intermolecular tuning of calmodulin by target peptides and proteins: Differential effects on Ca2+ binding and implications for kinase activation

    Olve B. Peersen;Travis S. Madsen;Joseph J. Falke

  • Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics.

    Jefferson D. Knight;Michael G. Lerner;Joan G. Marcano-Velázquez;Richard W. Pastor

  • Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages.

    John H. Evans;Joseph J. Falke

  • Structure of a bacterial sensory receptor. A site-directed sulfhydryl study.

    J J Falke;A F Dernburg;D A Sternberg;N Zalkin

  • Lock On/Off Disulfides Identify the Transmembrane Signaling Helix of the Aspartate Receptor

    Stephen A. Chervitz;Joseph J. Falke

  • Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2.

    Eric A. Nalefski;Thomas McDonagh;William Somers;Jasbir Seehra

  • Cysteine and Disulfide Scanning Reveals Two Amphiphilic Helices in the Linker Region of the Aspartate Chemoreceptor

    Scott L. Butler;Joseph J. Falke

  • Specific Translocation of Protein Kinase Cα to the Plasma Membrane Requires Both Ca2+ and PIP2 Recognition by Its C2 Domain

    John H. Evans;Diana Murray;Christina C. Leslie;Joseph J. Falke

Frequent Co-Authors

Roger L. Williams
Roger L. Williams University of Cambridge
Gregory A. Voth
Gregory A. Voth University of Chicago
Daniel E. Koshland
Daniel E. Koshland University of California, Berkeley
Gerald L. Hazelbauer
Gerald L. Hazelbauer University of Missouri
Steven F. Maier
Steven F. Maier University of Colorado Boulder
Mark R. Hutchinson
Mark R. Hutchinson University of Adelaide
Hang Yin
Hang Yin Tsinghua University
Grant J. Jensen
Grant J. Jensen California Institute of Technology
Melvin I. Simon
Melvin I. Simon California Institute of Technology
Linda R. Watkins
Linda R. Watkins University of Colorado Boulder

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