World's Best Scientists 2026 revealed!
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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
137
Citations
55770
World Ranking
144
National Ranking
93

Melvin I. Simon publication distribution in Molecular Biology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Molecular Biology in 2026. The highlighted bar marks where Melvin I. Simon sits on this spectrum.

47–56 publications: 7 scientists 57–66 publications: 17 scientists 67–76 publications: 65 scientists 77–86 publications: 90 scientists 87–96 publications: 125 scientists 97–106 publications: 131 scientists 107–116 publications: 162 scientists 117–126 publications: 177 scientists 127–136 publications: 158 scientists 137–146 publications: 158 scientists 147–156 publications: 146 scientists 157–166 publications: 159 scientists 167–176 publications: 131 scientists 177–186 publications: 110 scientists 187–196 publications: 112 scientists 197–206 publications: 100 scientists 207–216 publications: 89 scientists 217–226 publications: 98 scientists 227–236 publications: 74 scientists 237–246 publications: 72 scientists 247–256 publications: 63 scientists 257–266 publications: 53 scientists 267–276 publications: 54 scientists 277–286 publications: 49 scientists 287–296 publications: 52 scientists 297–306 publications: 43 scientists 307–316 publications: 46 scientists 317–326 publications: 41 scientists 327–336 publications: 42 scientists 337–346 publications: 31 scientists 347–356 publications: 28 scientists 357–366 publications: 29 scientists 367–376 publications: 26 scientists 377–386 publications: 24 scientists 387–396 publications: 24 scientists 397–406 publications: 14 scientists 407–416 publications: 13 scientists 417–426 publications: 20 scientists 427–436 publications: 12 scientists 437–446 publications: 20 scientists 447–456 publications: 11 scientists 457–466 publications: 10 scientists 467–476 publications: 14 scientists 477–486 publications: 14 scientists 487–496 publications: 10 scientists 497–506 publications: 13 scientists 507–516 publications: 13 scientists 517–526 publications: 2 scientists 527–536 publications: 4 scientists 537–546 publications: 6 scientists 547–556 publications: 8 scientists 557–563 publications: 6 scientists 564+ publications: 100 scientists
47 publications 564+

This scientist: 344 publications — 86th percentile

86% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 564 publications or more.

Melvin I. Simon D-index placement in Molecular Biology in 2026

The chart shows the D-index (discipline H-index) distribution of Molecular Biology scientists ranked by Research.com in 2026. The highlighted bar marks where Melvin I. Simon sits on this spectrum.

40–41 D-Index: 36 scientists 42–43 D-Index: 101 scientists 44–45 D-Index: 115 scientists 46–47 D-Index: 121 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 130 scientists 52–53 D-Index: 106 scientists 54–55 D-Index: 116 scientists 56–57 D-Index: 113 scientists 58–59 D-Index: 129 scientists 60–61 D-Index: 120 scientists 62–63 D-Index: 105 scientists 64–65 D-Index: 131 scientists 66–67 D-Index: 95 scientists 68–69 D-Index: 97 scientists 70–71 D-Index: 106 scientists 72–73 D-Index: 83 scientists 74–75 D-Index: 89 scientists 76–77 D-Index: 77 scientists 78–79 D-Index: 70 scientists 80–81 D-Index: 73 scientists 82–83 D-Index: 60 scientists 84–85 D-Index: 48 scientists 86–87 D-Index: 45 scientists 88–89 D-Index: 50 scientists 90–91 D-Index: 31 scientists 92–93 D-Index: 51 scientists 94–95 D-Index: 43 scientists 96–97 D-Index: 38 scientists 98–99 D-Index: 39 scientists 100–101 D-Index: 41 scientists 102–103 D-Index: 29 scientists 104–105 D-Index: 33 scientists 106–107 D-Index: 35 scientists 108–109 D-Index: 20 scientists 110–111 D-Index: 38 scientists 112–113 D-Index: 19 scientists 114–115 D-Index: 28 scientists 116–117 D-Index: 13 scientists 118–119 D-Index: 23 scientists 120–121 D-Index: 16 scientists 122–123 D-Index: 15 scientists 124–125 D-Index: 11 scientists 126–127 D-Index: 21 scientists 128–129 D-Index: 7 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 14 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 9 scientists 138–139 D-Index: 8 scientists 140–141 D-Index: 16 scientists 142–143 D-Index: 7 scientists 144 D-Index: 7 scientists 145+ D-Index: 100 scientists
40 D-Index 145+

This scientist: 137 D-Index — 96th percentile

96% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 145 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 1987 - Fellow of the American Academy of Arts and Sciences
  • 1985 - Member of the National Academy of Sciences
  • 1978 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His primary areas of investigation include Biochemistry, G protein, Heterotrimeric G protein, G alpha subunit and Phosphorylation. The G protein study combines topics in areas such as Molecular biology, Phospholipase C and Alpha. He works mostly in the field of Molecular biology, limiting it down to topics relating to Cholera toxin and, in certain cases, Amino acid.

Genetics and Cell biology are the focus of his Heterotrimeric G protein studies. His G alpha subunit study deals with Peptide sequence intersecting with Nucleic acid sequence. His biological study spans a wide range of topics, including Histidine kinase, Biophysics and Chemotaxis.

His most cited work include:

  • Diversity of G proteins in signal transduction. (1738 citations)
  • Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. (1532 citations)
  • The DNA sequence of human chromosome 22 (1150 citations)

What are the main themes of his work throughout his whole career to date?

Melvin I. Simon mostly deals with Biochemistry, G protein, Molecular biology, Cell biology and Genetics. His work focuses on many connections between Biochemistry and other disciplines, such as Biophysics, that overlap with his field of interest in Rhodopsin. His study connects G alpha subunit and G protein.

His study looks at the relationship between Molecular biology and fields such as Gene expression, as well as how they intersect with chemical problems. His Cell biology research focuses on Signal transduction in particular. His Phosphorylation research is multidisciplinary, incorporating perspectives in Histidine kinase, Mutant and Chemotaxis.

He most often published in these fields:

  • Biochemistry (33.59%)
  • G protein (27.73%)
  • Molecular biology (25.78%)

What were the highlights of his more recent work (between 2001-2016)?

  • Cell biology (25.00%)
  • Signal transduction (18.75%)
  • Biochemistry (33.59%)

In recent papers he was focusing on the following fields of study:

Melvin I. Simon mainly focuses on Cell biology, Signal transduction, Biochemistry, G protein and Receptor. His Cell biology research integrates issues from Retinal degeneration, Rhodopsin, Visual phototransduction and Ectopic expression. His work carried out in the field of Signal transduction brings together such families of science as Molecular biology and Computational biology.

Melvin I. Simon has included themes like Cell culture and G alpha subunit in his G protein study. Melvin I. Simon usually deals with Receptor and limits it to topics linked to Neuroscience and Transduction. His study on G beta-gamma complex is often connected to Physiological responses as part of broader study in Heterotrimeric G protein.

Between 2001 and 2016, his most popular works were:

  • A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression (273 citations)
  • RGS9 Modulates Dopamine Signaling in the Basal Ganglia (238 citations)
  • Evidence for two apoptotic pathways in light-induced retinal degeneration (211 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Cell biology, Biochemistry, Receptor, Visual phototransduction and Rhodopsin are his primary areas of study. His Cell biology course of study focuses on Transcription factor and p38 mitogen-activated protein kinases, Ectopic expression, MAPK/ERK pathway and Muscarinic acetylcholine receptor. His Biophysics research extends to the thematically linked field of Biochemistry.

His work on Gq alpha subunit, HEK 293 cells and Calcium signaling as part of general Receptor research is frequently linked to CpG site, thereby connecting diverse disciplines of science. His work deals with themes such as Knockout mouse and Transducin, which intersect with Visual phototransduction. His studies in Rhodopsin integrate themes in fields like Arrestin, Phosphodiesterase activity, Transient receptor potential channel and Mechanism of action.

Best Publications

  • Diversity of G proteins in signal transduction.

    Melvin I. Simon;Michael P. Strathmann;Narasimhan Gautam

  • Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.

    Hiroaki Shizuya;Bruce Birren;Ung-Jin Kim;Valeria Mancino

  • The DNA sequence of human chromosome 22

    I. Dunham;N. Shimizu;B. A. Roe;S. Chissoe

  • A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons

    Xinzhong Dong;Sang kyou Han;Mark J. Zylka;Melvin I. Simon

  • Defective platelet activation in G alpha q deficient mice

    Stefan Offermanns;Christopher F. Toombs;Yi-Hui Hu;Melvin I. Simon

  • Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C

    Stefan Offermanns;Melvin I. Simon

  • Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis.

    J F Hess;K Oosawa;N Kaplan;M I Simon

  • Signal Transduction Pathways Involving Protein Phosphorylation in Prokaryotes

    Rorbert B. Bourret;Katherine A. Borkovich;Melvin I. Simon

  • Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

    Arieh Katz;Dianqing Wu;Melvin I. Simon

  • Construction and characterization of a human bacterial artificial chromosome library

    Ung Jin Kim;Bruce W. Birren;Tatiana Slepak;Valeria Mancino

  • Structure of CheA, a Signal-Transducing Histidine Kinase

    Alexandrine M. Bilwes;Lisa A. Alex;Brian R. Crane;Melvin I. Simon

  • G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

    Michael Strathmann;Melvin I. Simon

  • The genome of Nanoarchaeum equitans: Insights into early archaeal evolution and derived parasitism

    Elizabeth Waters;Michael J. Hohn;Ivan Ahel;David E. Graham

  • Homologies between signal transducing G proteins and ras gene products

    James B. Hurley;Melvin I. Simon;David B. Teplow;Janet D. Robishaw

  • Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency

    Stefan Offermanns;Valeria Mancino;Jean-Paul Revel;Melvin I. Simon

  • Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1

    Ching Kang Chen;Marie E Burns;Wel He;Theodorø G. Wensel

  • A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression

    Kum Joo Shin;Estelle A. Wall;Joelle R. Zavzavadjian;Leah A. Santat

  • Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.

    Dianqing Wu;Chang Ho Lee;Sue Goo Rhee;Melvin I. Simon

  • Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis.

    J. Fred Hess;Robert B. Bourret;Melvin I. Simon

  • Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

    Stephen Gutowski;Alan Smrcka;Lisa Nowak;Dianging Wu

Frequent Co-Authors

Stefan Offermanns
Stefan Offermanns Max Planck Society
Brian R. Crane
Brian R. Crane Cornell University
Iain D. C. Fraser
Iain D. C. Fraser National Institutes of Health
Henry A. Lester
Henry A. Lester California Institute of Technology
Julie R. Korenberg
Julie R. Korenberg University of Utah
Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
Leroy Hood
Leroy Hood University of Washington
Xinzhong Dong
Xinzhong Dong Johns Hopkins University School of Medicine
Paul W. Sternberg
Paul W. Sternberg California Institute of Technology
Thomas J. Hudson
Thomas J. Hudson Ontario Institute for Cancer Research

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