Melvin I. Simon

What is he best known for?

The fields of study he is best known for:

• Gene
• Enzyme
• DNA

His primary areas of investigation include Biochemistry, G protein, Heterotrimeric G protein, G alpha subunit and Phosphorylation. The G protein study combines topics in areas such as Molecular biology, Phospholipase C and Alpha. He works mostly in the field of Molecular biology, limiting it down to topics relating to Cholera toxin and, in certain cases, Amino acid.

Genetics and Cell biology are the focus of his Heterotrimeric G protein studies. His G alpha subunit study deals with Peptide sequence intersecting with Nucleic acid sequence. His biological study spans a wide range of topics, including Histidine kinase, Biophysics and Chemotaxis.

His most cited work include:

• Diversity of G proteins in signal transduction. (1738 citations)
• Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. (1532 citations)
• The DNA sequence of human chromosome 22 (1150 citations)

What are the main themes of his work throughout his whole career to date?

Melvin I. Simon mostly deals with Biochemistry, G protein, Molecular biology, Cell biology and Genetics. His work focuses on many connections between Biochemistry and other disciplines, such as Biophysics, that overlap with his field of interest in Rhodopsin. His study connects G alpha subunit and G protein.

His study looks at the relationship between Molecular biology and fields such as Gene expression, as well as how they intersect with chemical problems. His Cell biology research focuses on Signal transduction in particular. His Phosphorylation research is multidisciplinary, incorporating perspectives in Histidine kinase, Mutant and Chemotaxis.

He most often published in these fields:

• Biochemistry (33.59%)
• G protein (27.73%)
• Molecular biology (25.78%)

What were the highlights of his more recent work (between 2001-2016)?

• Cell biology (25.00%)
• Signal transduction (18.75%)
• Biochemistry (33.59%)

In recent papers he was focusing on the following fields of study:

Melvin I. Simon mainly focuses on Cell biology, Signal transduction, Biochemistry, G protein and Receptor. His Cell biology research integrates issues from Retinal degeneration, Rhodopsin, Visual phototransduction and Ectopic expression. His work carried out in the field of Signal transduction brings together such families of science as Molecular biology and Computational biology.

Melvin I. Simon has included themes like Cell culture and G alpha subunit in his G protein study. Melvin I. Simon usually deals with Receptor and limits it to topics linked to Neuroscience and Transduction. His study on G beta-gamma complex is often connected to Physiological responses as part of broader study in Heterotrimeric G protein.

Between 2001 and 2016, his most popular works were:

• A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression (273 citations)
• RGS9 Modulates Dopamine Signaling in the Basal Ganglia (238 citations)
• Evidence for two apoptotic pathways in light-induced retinal degeneration (211 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Enzyme
• DNA

Cell biology, Biochemistry, Receptor, Visual phototransduction and Rhodopsin are his primary areas of study. His Cell biology course of study focuses on Transcription factor and p38 mitogen-activated protein kinases, Ectopic expression, MAPK/ERK pathway and Muscarinic acetylcholine receptor. His Biophysics research extends to the thematically linked field of Biochemistry.

His work on Gq alpha subunit, HEK 293 cells and Calcium signaling as part of general Receptor research is frequently linked to CpG site, thereby connecting diverse disciplines of science. His work deals with themes such as Knockout mouse and Transducin, which intersect with Visual phototransduction. His studies in Rhodopsin integrate themes in fields like Arrestin, Phosphodiesterase activity, Transient receptor potential channel and Mechanism of action.