World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
78
Citations
24212
World Ranking
3761
National Ranking
1200

Biology and Biochemistry

D-Index
82
Citations
27825
World Ranking
3654
National Ranking
1820

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Heidi E. Hamm is affiliated with Vanderbilt University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these fields, their work explores several subfields including Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, Hematology, and Cancer Research.

The scientist's research covers a variety of main topics, emphasizing receptor mechanisms and signaling, cellular transport and secretion, neuroscience and neuropharmacology research, retinal development and disorders, photoreceptor and optogenetics research, blood coagulation and thrombosis mechanisms, and protease and inhibitor mechanisms.

Heidi E. Hamm has published significantly across recognized venues, with multiple papers in bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Frontiers in Molecular Neuroscience, Cell Reports, and the Journal of Clinical Investigation.

Recent notable papers include:

  • Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening, 2024, ACS Pharmacology & Translational Science
  • Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity, 2023, Journal of Clinical Investigation
  • Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release, 2022, Cell Reports
  • Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study, 2020, Molecular Cancer Therapeutics
  • Position of rhodopsin photoisomerization on the disk surface confers variability to the rising phase of the single photon response in vertebrate rod photoreceptors, 2020, PLoS ONE

Heidi E. Hamm collaborates frequently with a number of researchers including Zack Zurawski, Kevin Erreger, Yun Young Yim, Ali İ. Kaya, and Jens Meiler, indicating a network of ongoing research partnerships.

The scientist was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • The many faces of G protein signaling.

    Heidi E. Hamm

  • Heterotrimeric G protein activation by G-protein-coupled receptors

    William M. Oldham;Heidi E. Hamm

  • The 2.0 Å crystal structure of a heterotrimeric G protein

    David G. Lambright;John Sondek;Andrew Bohm;Nikolai P. Skiba

  • The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.

    Joseph P. Noel;Heidi E. Hamm;Heidi E. Hamm;Paul B. Sigler

  • Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

    John Sondek;Andrew Bohm;David G. Lambright;David G. Lambright;Heidi E. Hamm

  • Insights into G protein structure, function, and regulation

    Theresa M. Cabrera-Vera;Jurgen Vanhauwe;Tarita O. Thomas;Martina Medkova

  • Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.

    David G. Lambright;Joseph P. Noel;Joseph P. Noel;Heidi E. Hamm;Paul B. Sigler

  • GTPase Mechanism of Gproteins From the 1.7-A Crystal Structure of Transducin alpha-GDP-AIF-4

    John Sondek;David G. Lambright;Joseph P. Noel;Heidi E. Hamm;Heidi E. Hamm

  • D2 Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+ Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade

    Salvador Hernández-López;Tatiana Tkatch;Enrique Perez-Garci;Elvira Galarraga

  • Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit

    Heidi E. Hamm;Dusanka Deretic;Anatol Arendt;Paul A. Hargrave

  • Molecular Basis for Interactions of G Protein βγ Subunits with Effectors

    Carolyn E. Ford;Nikolai P. Skiba;Hyunsu Bae;Yehia Daaka

  • Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions

    Hyunsu Bae;Kristin Anderson;Lori A. Flood;Nikolai P. Skiba

  • Retinal rhythms in chicks: circadian variation in melantonin and serotonin N-acetyltransferase activity

    Heidi E. Hamm;Michael Menaker

  • A Novel Bifunctional Phospholipase C That Is Regulated by Gα12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway

    Isabel Lopez;Eric C. Mak;Jirong Ding;Heidi E. Hamm

  • Heterotrimeric G proteins.

    Heidi E Hamm;Annette Gilchrist

  • Structural basis of function in heterotrimeric G proteins.

    William M. Oldham;Heidi E. Hamm

  • Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway

    Richard D. Minshall;Chinnaswamy Tiruppathi;Stephen M. Vogel;Walter D. Niles

  • Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro.

    Joseph S. Takahashi;Heidi Hamm;Michael Menaker

  • How activated receptors couple to G proteins

    Heidi E. Hamm

  • G Protein βγ Subunit-Mediated Presynaptic Inhibition: Regulation of Exocytotic Fusion Downstream of Ca2+ Entry

    Trillium Blackmer;Eric C. Larsen;Michiko Takahashi;Thomas F. J. Martin

Frequent Co-Authors

Craig W. Lindsley
Craig W. Lindsley Vanderbilt University
Vsevolod V. Gurevich
Vsevolod V. Gurevich Vanderbilt University
Jens Meiler
Jens Meiler Vanderbilt University
Shaun R. Stauffer
Shaun R. Stauffer Cleveland Clinic
Wayne L. Hubbell
Wayne L. Hubbell University of California, Los Angeles
David G. Lambright
David G. Lambright University of Massachusetts Chan Medical School
Lilianna Solnica-Krezel
Lilianna Solnica-Krezel Washington University in St. Louis
Joseph P. Noel
Joseph P. Noel Salk Institute for Biological Studies
Kevin L. Schey
Kevin L. Schey Vanderbilt University
John Sondek
John Sondek University of North Carolina at Chapel Hill

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