World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
20092
World Ranking
8098
National Ranking
3667

Research.com Recognitions

  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Stephen R. Sprang is affiliated with the University of Montana in the United States. Their research spans key areas within biochemistry, genetics, and molecular biology, with a focus on molecular biology and materials chemistry, as well as cellular and molecular neuroscience and cell biology. Their work encompasses both fundamental molecular mechanisms and applications related to enzymology and signaling pathways.

The primary fields of study covered by Sprang include:

  • Biochemistry, Genetics and Molecular Biology

Within these fields, they have contributed notably to subfields such as:

  • Molecular Biology
  • Materials Chemistry
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Electronic, Optical and Magnetic Materials

Sprang has extensively worked on several research topics that include:

  • Protein Kinase Regulation and GTPase Signaling
  • Enzyme Structure and Function
  • Metabolism, Diabetes, and Cancer
  • Neuroscience and Neuropharmacology Research
  • Cancer-related gene regulation
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer

Their recent publications highlight a range of experimental approaches and structural studies. Notable papers include:

  • Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1, 2020, Nature Communications
  • The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a), 2021, Journal of Structural Biology X
  • The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A, 2023, eLife
  • Application of sulfur SAD to small crystals with a large asymmetric unit and anomalous substructure, 2022, Acta Crystallographica Section D Structural Biology
  • A galactose-based auto-expression system improves T7-inducible protein production in Escherichia coli, 2025, Scientific Reports

Frequent collaborators in their research include:

  • Levi J. McClelland
  • Tung-Chung Mou
  • Cindee Yates-Hansen
  • Kaiming Zhang
  • Jake Johnston

Their work has appeared regularly in publication venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Structural Biology X
  • eLife
  • Acta Crystallographica Section D Structural Biology

Stephen R. Sprang has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since the year 2000.

Best Publications

  • The structure of the G protein heterotrimer Giα1β1γ2

    Mark A. Wall;David E. Coleman;Ethan Lee;Jorge A. Iñiguez-Lluhi

  • G PROTEIN MECHANISMS: Insights from Structural Analysis

    Stephen R. Sprang

  • Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gsα·GTPγS

    John J. G. Tesmer;Roger K. Sunahara;Alfred G. Gilman;Stephen R. Sprang

  • Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.

    David E. Coleman;Albert M. Berghuis;Ethan Lee;Maurine E. Linder

  • Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

    John J.G. Tesmer;David M. Berman;Alfred G. Gilman;Stephen R. Sprang

  • Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.

    R.Bryan Sutton;Bazbek A Davletov;Albert M Berghuis;Thomas C Sudhof

  • The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

    M J Eck;S R Sprang

  • Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP.

    Sylvie Blond-Elguindi;Steven E. Cwirla;William J. Dower;Robert J. Lipshutz

  • Crystal structure of the adenylyl cyclase activator Gsalpha

    Roger K. Sunahara;John J. G. Tesmer;Alfred G. Gilman;Stephen R. Sprang

  • Tertiary and Quaternary Structural Changes in Giα1 Induced by GTP Hydrolysis

    Mark B. Mixon;Ethan Lee;David E. Coleman;Albert M. Berghuis

  • Modularity in the TNF-receptor family

    James H. Naismith;Stephen R. Sprang

  • Two-Metal-Ion Catalysis in Adenylyl Cyclase

    John J. G. Tesmer;Roger K. Sunahara;Roger A. Johnson;Gilles Gosselin

  • Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta.

    Jiandong Zhang;Lawrence S. Cousens;Phillip J. Barr;Stephen R. Sprang

  • Structural changes in glycogen phosphorylase induced by phosphorylation.

    S. R. Sprang;K. R. Acharya;Elizabeth J Goldsmith;D. I. Stuart

  • Cytokine structural taxonomy and mechanisms of receptor engagement

    Stephen R. Sprang;J. Fernando Bazan

  • The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.

    S Sprang;T Standing;RJ Fletterick;RM Stroud

  • The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

    M J Eck;M Ultsch;E Rinderknecht;A M de Vos

  • Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases.

    Roger K. Sunahara;Annie Beuve;John J.G. Tesmer;Stephen R. Sprang

  • Structure of the protein kinase Cβ phospholipid-binding C2 domain complexed with Ca2+

    R Bryan Sutton;Stephen R Sprang

  • Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor

    James H. Naismith;Tracey Q. Devine;Barbara J. Brandhuber;Stephen R. Sprang

Frequent Co-Authors

Robert J. Fletterick
Robert J. Fletterick University of California, San Francisco
Alfred G. Gilman
Alfred G. Gilman The University of Texas Southwestern Medical Center
John J. G. Tesmer
John J. G. Tesmer Purdue University West Lafayette
Roland Seifert
Roland Seifert Hannover Medical School
Elizabeth J. Goldsmith
Elizabeth J. Goldsmith The University of Texas Southwestern Medical Center
Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
James H. Naismith
James H. Naismith Rosalind Franklin Institute
William J. Rutter
William J. Rutter University of California, San Francisco
Charles S. Craik
Charles S. Craik University of California, San Francisco
Roger K. Sunahara
Roger K. Sunahara University of California, San Diego

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