2000 - Fellow of the American Association for the Advancement of Science (AAAS)
His primary areas of study are Biochemistry, Stereochemistry, Protein structure, Binding site and Adenylyl cyclase. In the field of Biochemistry, his study on G protein, G alpha subunit and Heat shock protein overlaps with subjects such as Structural unit. His research in G protein is mostly concerned with GTPase-activating protein.
His research in Stereochemistry intersects with topics in Heterotrimeric G protein and Active site. His Protein structure study incorporates themes from Crystallography, Receptor and Extracellular. The Binding site study combines topics in areas such as Antiparallel, Recombinant DNA, Dimer, Trimer and Trypsin.
Stephen R. Sprang mainly investigates Biochemistry, G protein, Stereochemistry, Heterotrimeric G protein and Cell biology. His study in Biochemistry focuses on Adenylyl cyclase, G beta-gamma complex, Glycogen phosphorylase, Enzyme and Gs alpha subunit. Stephen R. Sprang interconnects Guanine nucleotide exchange factor, GTPase, G protein-coupled receptor, Biophysics and GTP' in the investigation of issues within G protein.
In his study, which falls under the umbrella issue of Biophysics, Extracellular is strongly linked to Receptor. His Stereochemistry study integrates concerns from other disciplines, such as Crystallography, Nucleotide, Active site, Protein structure and Binding site. His Heterotrimeric G protein research integrates issues from Chaperone and G alpha subunit.
His main research concerns G protein, Biochemistry, Heterotrimeric G protein, Biophysics and Guanine nucleotide exchange factor. His G protein research includes elements of Cell signaling, G protein-coupled receptor and Chaperone. His multidisciplinary approach integrates Biochemistry and Nucleotide exchange factor in his work.
His research integrates issues of Gs alpha subunit, GTPase-activating protein and Gq alpha subunit in his study of Heterotrimeric G protein. Stephen R. Sprang combines subjects such as Nucleotide and Stereochemistry with his study of Guanine nucleotide exchange factor. Stephen R. Sprang has researched Stereochemistry in several fields, including Peroxidase, Adenylyl cyclase, Protein structure and Heme.
Stephen R. Sprang spends much of his time researching Biochemistry, Stereochemistry, G protein, GTP-Binding Protein alpha Subunits and Heterotrimeric G protein. His work on Allosteric regulation, Binding site and Signal peptide as part of general Biochemistry research is frequently linked to Junin virus and Glycoprotein complex, bridging the gap between disciplines. His biological study spans a wide range of topics, including Peroxidase, Electron transport chain, Guanine and Heme.
His G protein research incorporates elements of Guanine nucleotide exchange factor and G protein-coupled receptor. His GTP-Binding Protein alpha Subunits study combines topics from a wide range of disciplines, such as GTPase-activating protein, Biophysics, Protein subunit, Chaperone and Gs alpha subunit. GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, GTPase and GTP-binding protein regulators is closely connected to GTP' in his research, which is encompassed under the umbrella topic of Heterotrimeric G protein.
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The structure of the G protein heterotrimer Giα1β1γ2
Mark A. Wall;David E. Coleman;Ethan Lee;Jorge A. Iñiguez-Lluhi.
G PROTEIN MECHANISMS: Insights from Structural Analysis
Stephen R. Sprang.
Annual Review of Biochemistry (1997)
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
David E. Coleman;Albert M. Berghuis;Ethan Lee;Maurine E. Linder.
Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gsα·GTPγS
John J. G. Tesmer;Roger K. Sunahara;Alfred G. Gilman;Stephen R. Sprang.
Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis
John J.G. Tesmer;David M. Berman;Alfred G. Gilman;Stephen R. Sprang.
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.
R.Bryan Sutton;Bazbek A Davletov;Albert M Berghuis;Thomas C Sudhof.
Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP.
Sylvie Blond-Elguindi;Steven E. Cwirla;William J. Dower;Robert J. Lipshutz.
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
M J Eck;S R Sprang.
Journal of Biological Chemistry (1990)
Cytokine structural taxonomy and mechanisms of receptor engagement
Stephen R. Sprang;J. Fernando Bazan.
Current Opinion in Structural Biology (1993)
Modularity in the TNF-receptor family
James H. Naismith;Stephen R. Sprang.
Trends in Biochemical Sciences (1998)
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