What is he best known for?
The fields of study he is best known for:
His primary areas of study are Biochemistry, Protein structure, Biophysics, Kinesin and Cell biology.
His research links Scrapie with Biochemistry.
Robert J. Fletterick has included themes like PrPSc Proteins, Electronic structure, Protein engineering, Low-barrier hydrogen bond and Computational biology in his Protein structure study.
His Biophysics study integrates concerns from other disciplines, such as Clathrin and Actin.
His study in Kinesin is interdisciplinary in nature, drawing from both Motor protein and Myosin.
The Cell biology study combines topics in areas such as Genetics, Growth-hormone-releasing hormone receptor, Coactivator, Hormone response element and Thyroid hormone receptor alpha.
His most cited work include:
- Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. (1968 citations)
- Structure and specificity of nuclear receptor–coactivator interactions (848 citations)
- A structural role for hormone in the thyroid hormone receptor (815 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Biochemistry, Stereochemistry, Glycogen phosphorylase, Protein structure and Binding site.
Robert J. Fletterick combines topics linked to Biophysics with his work on Biochemistry.
His work deals with themes such as Kinesin, Microtubule and Actin, which intersect with Biophysics.
His work focuses on many connections between Stereochemistry and other disciplines, such as Trypsin, that overlap with his field of interest in Histidine.
The concepts of his Glycogen phosphorylase study are interwoven with issues in Isozyme, Allosteric regulation and Phosphorylation.
His Nuclear receptor study combines topics in areas such as Coactivator, Receptor, Ligand and Cell biology.
He most often published in these fields:
- Biochemistry (44.77%)
- Stereochemistry (18.63%)
- Glycogen phosphorylase (16.67%)
What were the highlights of his more recent work (between 2008-2019)?
- Cell biology (12.75%)
- Nuclear receptor (14.05%)
- Receptor (11.11%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Cell biology, Nuclear receptor, Receptor, Liver receptor homolog-1 and Biochemistry.
The study incorporates disciplines such as Coactivator, Endocrinology, Gene and Internal medicine in addition to Cell biology.
His Nuclear receptor research is multidisciplinary, incorporating perspectives in Signal transduction, Transcription, Binding site and Ligand.
His biological study spans a wide range of topics, including Protein structure, Regulation of gene expression, Biophysics and Orphan Nuclear Receptors.
The various areas that Robert J. Fletterick examines in his Receptor study include Lead compound, Cysteine and Prostate cancer, Androgen receptor.
Biochemistry is often connected to In vivo in his work.
Between 2008 and 2019, his most popular works were:
- Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells (98 citations)
- Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation (92 citations)
- Conformation Switching of Clathrin Light Chain Regulates Clathrin Lattice Assembly (66 citations)
In his most recent research, the most cited papers focused on:
Robert J. Fletterick spends much of his time researching Cell biology, Nuclear receptor, Liver receptor homolog-1, Receptor and Protein structure.
His work on Kinesin 13 is typically connected to Histone methylation as part of general Cell biology study, connecting several disciplines of science.
His Nuclear receptor study contributes to a more complete understanding of Biochemistry.
His Biophysics research extends to Biochemistry, which is thematically connected.
His work deals with themes such as Heat shock protein, Cancer cell, Endocrinology and Prostate cancer, which intersect with Receptor.
His research integrates issues of Clathrin, Endocytosis, Endocytic cycle, Coated vesicle and Clathrin adaptor proteins in his study of Protein structure.
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