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Biology and Biochemistry

D-Index
67
Citations
20249
World Ranking
8095
National Ranking
3665

Research.com Recognitions

  • 2019 - Fellow of the American Academy of Arts and Sciences
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Holly A. Ingraham is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on various subfields including Physiology, Immunology, Molecular Biology, Genetics, and Gastroenterology.

Their scholarly work covers key topics such as gastrointestinal motility and disorders, estrogen and related hormone effects, ion channels and receptors, regulation of appetite and obesity, RNA research and splicing, hypothalamic control of reproductive hormones, and diet and metabolism studies.

Notable recent publications by Holly A. Ingraham include:

  • Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling, 2021, Annual Review of Physiology
  • Gut enterochromaffin cells drive visceral pain and anxiety, 2023, Nature
  • Oestrogen engages brain MC4R signalling to drive physical activity in female mice, 2021, Nature
  • An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice, 2022, Science
  • A maternal brain hormone that builds bone, 2024, Nature

Frequent coauthors who have collaborated extensively with them include William C. Krause, Candice B. Herber, Stuart M. Brierley, David Julius, and Joni Nikkanen.

Their work has been published in recurring venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature, Science, the Journal of the Endocrine Society, and the Annual Review of Physiology.

Holly A. Ingraham has also contributed to book publications, including a title within the RAND Corporation eBooks collection titled "RAND Summer Institute Lecture Series 2020," published in 2021.

Ingraham has been recognized by their professional peers through fellowship awards such as the Fellow of the American Academy of Arts and Sciences (2019) and Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.

    Holly A. Ingraham;Ruoping Chen;Harry J. Mangalam;Harry P. Elsholtz

  • Anti-Müllerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary

    Alexandra L. L. Durlinger;Maria J. G. Gruijters;Piet Kramer;Bas Karels

  • Expression of a large family of POU-domain regulatory genes in mammalian brain development.

    Xi He;Maurice N. Treacy;Donna M. Simmons;Donna M. Simmons;Holly A. Ingraham;Holly A. Ingraham

  • The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products

    W Herr;R A Sturm;R G Clerc;L M Corcoran

  • Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.

    D M Simmons;J W Voss;H A Ingraham;J M Holloway

  • Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways

    Nicholas W. Bellono;James R. Bayrer;Duncan B. Leitch;Joel Castro;Joel Castro

  • Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases.

    Y. Ikeda;Wen-Hui Shen;H. A. Ingraham;K. L. Parker

  • Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: A link to the sex determination cascade

    Wen-Hui Shen;Chris C.D. Moore;Yayoi Ikeda;Keith L. Parker

  • Wilms' Tumor 1 and Dax-1 Modulate the Orphan Nuclear Receptor SF-1 in Sex-Specific Gene Expression

    Mark W Nachtigal;Yoshifumi Hirokawa;Debra L Enyeart-VanHouten;John N Flanagan

  • The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.

    Holly A. Ingraham;Deepak S. Lala;Yayoi Ikeda;Xunrong Luo

  • Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.

    R. W. Pfäffle;G. E. DiMattia;J. S. Parks;M. R. Brown

  • Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

    Irina N. Krylova;Elena P. Sablin;Jamie Moore;Robert X. Xu

  • The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

    Holly A. Ingraham;Sarah E. Flynn;Jeffrey W. Voss;Vivian R. Albert

  • Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.

    Gary D. Hammer;Irina Krylova;Yixian Zhang;Beatrice D. Darimont

  • Demasculinization and feminization of male gonads by atrazine: Consistent effects across vertebrate classes

    Tyrone B. Hayes;Lloyd L. Anderson;Val R. Beasley;Shane R. de Solla

  • A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.

    H J Mangalam;V R Albert;H A Ingraham;M Kapiloff

  • Direct G Protein Modulation of Cav2 Calcium Channels

    H. William Tedford;Gerald W. Zamponi

  • Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements.

    Ruoping Chen;Holly A. Ingraham;Maurice N. Treacy;Vivian R. Albert

  • The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian Inhibiting Substance, in vivo.

    Galicia Giuili;Wen-Hui Shen;Holly A. Ingraham

  • International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

    Gérard Benoit;Austin Cooney;Vincent Giguere;Holly Ingraham

Frequent Co-Authors

Robert J. Fletterick
Robert J. Fletterick University of California, San Francisco
Michael G. Rosenfeld
Michael G. Rosenfeld University of California, San Diego
Larry W. Swanson
Larry W. Swanson University of Southern California
David Julius
David Julius University of California, San Francisco
Gordon N. Gill
Gordon N. Gill University of California, San Diego
Daniel K. Nomura
Daniel K. Nomura University of California, Berkeley
Glen A. Evans
Glen A. Evans The University of Texas Southwestern Medical Center
Stuart M. Brierley
Stuart M. Brierley Flinders University
Herwig Baier
Herwig Baier Max Planck Society
Mary F. Dallman
Mary F. Dallman University of California, San Francisco

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