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Ken-ichirou Morohashi

Ken-ichirou Morohashi

D-Index & Metrics

Genetics

D-Index
68
Citations
13818
World Ranking
2453
National Ranking
95

Overview

Ken-ichirou Morohashi is affiliated with Kyushu University in Japan and is recognized for contributions primarily in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research covers several key subfields including Molecular Biology, Genetics, Reproductive Medicine, Physiology, and Cell Biology.

Morohashi's scholarly output includes numerous publications in peer-reviewed journals, addressing topics such as genetic and clinical aspects of sex determination, chromosomal abnormalities, and sexual differentiation. Other research topics connected to their work are renal and related cancers, muscle physiology and disorders, adipose tissue and metabolism, muscle metabolism and nutrition, and sperm and testicular function.

Frequent coauthors of Morohashi include Takashi Baba with nine joint publications, Miki Inoue and Shogo Yanai each with six, Fumiya Takahashi with five, and Yuichi Shima with three. Collaboration with these researchers spans various aspects of molecular biology and metabolism, reflecting a multidisciplinary approach in their scientific inquiries.

Morohashi's recent papers demonstrate a focus on developmental biology and metabolism with notable publications including:

  • "Generation of ovarian follicles from mouse pluripotent stem cells" (2021) published in Science
  • "Coordination of Multiple Cellular Processes by NR5A1/Nr5a1" (2020) published in Endocrinology and Metabolism
  • "Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle" (2021) published in Communications Biology
  • "Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression" (2024) published in Cell Reports
  • "Eicosapentaenoic acid changes muscle transcriptome and intervenes in aging-related fiber type transition in male mice" (2020) published in American Journal of Physiology-Endocrinology and Metabolism

The scientist frequently publishes in journals such as Communications Biology, Scientific Reports, Science, Endocrinology and Metabolism, and Cell Reports, showing a consistent engagement with multidisciplinary research communities focused on biology and medicine.

Best Publications

  • A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s

    Ken-Ichirou Morohashi;Shin Ichiro Honda;Yukio Inomata;Hiroshi Handa

  • Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.

    Kunio Kitamura;Masako Yanazawa;Noriyuki Sugiyama;Hirohito Miura

  • Foxl2 Up-Regulates Aromatase Gene Transcription in a Female-Specific Manner by Binding to the Promoter as Well as Interacting with Ad4 Binding Protein/Steroidogenic Factor 1

    De Shou Wang;Tohru Kobayashi;Lin Yan Zhou;Lin Yan Zhou;Bindhu Paul-Prasanth

  • Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz‐F1 disrupted mice

    Koh Shinoda;Hong Lei;Hironori Yoshii;Masatoshi Nomura

  • Mutations of ARX are associated with striking pleiotropy and consistent genotype–phenotype correlation

    Mitsuhiro Kato;Soma Das;Kristin Petras;Kunio Kitamura

  • Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction

    Takashi Baba;Junsei Mimura;Naohito Nakamura;Nobuhiro Harada

  • Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary

    M. D. Michael;M. W. Kilgore;K.-I. Morohashi;E. R. Simpson

  • Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans.

    Wu Qiang Fan;Toshihiko Yanase;Hidetaka Morinaga;Shigeki Gondo

  • Gene Structure of Human Cytochrome P-450(SCC), Cholesterol Desmolase

    Ken ichirou Morohashi;Kazuhiro Sogawa;Tsuneo Omura;Yoshiaki Fujii-kuriyama

  • Synergistic Activation of the Human Type II 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Promoter by the Transcription Factor Steroidogenic Factor-1/Adrenal 4-binding Protein and Phorbol Ester

    Susan Leers-Sucheta;Ken Ichirou Morohashi;J. Ian Mason;Michael H. Melner

  • Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes

    Yuichi Shima;Kanako Miyabayashi;Shogo Haraguchi;Tatsuhiko Arakawa

  • A critical time window of Sry action in gonadal sex determination in mice.

    Ryuji Hiramatsu;Shogo Matoba;Masami Kanai-Azuma;Naoki Tsunekawa

  • Gene regulation of steroidogenesis

    Tsuneo Omura;Ken ichirou Morohashi

  • LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1.

    Taiga Suzuki;Megumi Kasahara;Hidefumi Yoshioka;Ken ichirou Morohashi

  • Comparative localization of Dax‐1 and Ad4BP/SF‐1 during development of the hypothalamic‐pituitary‐gonadal axis suggests their closely related and distinct functions

    Yayoi Ikeda;Yoshie Takeda;Tatsuji Shikayama;Tokuo Mukai;Tokuo Mukai

  • Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.

    Hirofumi Mizusaki;Ken Kawabe;Tokuo Mukai;Etsuko Ariyoshi

  • Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues.

    K Morohashi;H Iida;M Nomura;O Hatano

  • Dax-1 as One of the Target Genes of Ad4BP/SF-1

    Ken Kawabe;Tatsuji Shikayama;Hisae Tsuboi;Sanae Oka

  • CXorf6 is a causative gene for hypospadias.

    Maki Fukami;Yuka Wada;Kanako Miyabayashi;Ichizo Nishino

  • Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.

    Tomoko Komatsu;Tomoko Komatsu;Hirofumi Mizusaki;Tokuo Mukai;Hidesato Ogawa

Frequent Co-Authors

Tsuneo Omura
Tsuneo Omura Kyushu University
Yasuyuki Ohkawa
Yasuyuki Ohkawa Kyushu University
Tsutomu Ogata
Tsutomu Ogata Hamamatsu University
Masatoshi Nomura
Masatoshi Nomura Kurume University
Yasushi Hiraoka
Yasushi Hiraoka Osaka University
Mitsuhiro Okamoto
Mitsuhiro Okamoto Osaka University
Hajime Nawata
Hajime Nawata Kyushu University
Haruhiko Akiyama
Haruhiko Akiyama Gifu University
Osamu Gotoh
Osamu Gotoh Japanese Foundation For Cancer Research
Yoichi Matsubara
Yoichi Matsubara Tohoku University

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