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Biology and Biochemistry

D-Index
74
Citations
25912
World Ranking
5488
National Ranking
2607

Research.com Recognitions

  • 2020 - Fellow of the American Academy of Arts and Sciences
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Blanche Capel is affiliated with Duke University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant work in molecular biology, genetics, reproductive medicine, public health, environmental and occupational health, and immunology.

The scientist's main research topics include genetic and clinical aspects of sex determination and chromosomal abnormalities, reproductive biology and fertility, sperm and testicular function, sexual differentiation and disorders, animal genetics and reproduction, epigenetics and DNA methylation, and applications of CRISPR and genetic engineering.

Blanche Capel has contributed to several recent publications, including:

  • Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b, 2020, Science
  • Intravital imaging of mouse embryos, 2020, Science
  • Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad, 2022, Science Advances
  • Sertoli cell ablation and replacement of the spermatogonial niche in mouse, 2020, Nature Communications
  • A brief review of vertebrate sex evolution with a pledge for integrative research: towards ' sexomics ', 2021, Philosophical Transactions of the Royal Society B Biological Sciences

Their frequent co-authors include Jennifer McKey, Corey Bunce, Dilara N. Anbarci, Shannon Dupont, and Ceri Weber. Capel has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biology of Reproduction, Development, eLife, and Science.

Among professional recognitions, Blanche Capel was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 and a Fellow of the American Academy of Arts and Sciences in 2020.

Best Publications

  • A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

    John Gubbay;Jérôme Collignon;Peter Koopman;Blanche Capel

  • Circular transcripts of the testis-determining gene Sry in adult mouse testis

    Blanche Capel;Amanda Swain;Silvia Nicolis;Adam Hacker

  • Retinoic acid regulates sex-specific timing of meiotic initiation in mice.

    Jana Koubova;Douglas B. Menke;Qing Zhou;Blanche Capel

  • Expression of a candidate sex-determining gene during mouse testis differentiation

    Peter Koopman;Andrea Münsterberg;Blanche Capel;Nigel Vivian

  • One tissue, two fates: molecular genetic events that underlie testis versus ovary development.

    Jennifer Brennan;Blanche Capel

  • Expression of Sry, the mouse sex determining gene

    Adam Hacker;Blanche Capel;Peter Goodfellow;Robin Lovell-Badge

  • Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9

    Jennifer S. Colvin;Rebecca P. Green;Jennifer Schmahl;Blanche Capel

  • Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination

    Yuna Kim;Akio Kobayashi;Ryohei Sekido;Leo DiNapoli

  • Sertoli Cells of the Mouse Testis Originate from the Coelomic Epithelium

    Jeannie Karl;Blanche Capel

  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis

    Humphrey Hung-Chang Yao;Wendy Whoriskey;Blanche Capel

  • Pdgfr-α mediates testis cord organization and fetal Leydig cell development in the XY gonad

    Jennifer Brennan;Christopher Tilmann;Blanche Capel

  • Male-specific cell migration into the developing gonad.

    Janet Martineau;Katarina Nordqvist;Christopher Tilmann;Robin Lovell-Badge

  • Vertebrate sex determination: evolutionary plasticity of a fundamental switch.

    Blanche Capel

  • Sry induces cell proliferation in the mouse gonad

    Jennifer Schmahl;Eva M. Eicher;Linda L. Washburn;Blanche Capel

  • Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad

    Katherine Jeays-Ward;Christine Hoyle;Jennifer Brennan;Mathieu Dandonneau

  • Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

    Danielle M. Maatouk;Leo DiNapoli;Ashley Alvers;Keith L. Parker

  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours

    Kirsten K. Youngren;Douglas Coveney;Xiaoning Peng;Chitralekha Bhattacharya

  • Follistatin Operates Downstream of Wnt4 in Mammalian Ovary Organogenesis

    Humphrey H.C. Yao;Martin M. Matzuk;Carolina J. Jorgez;Douglas B. Menke

  • The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage

    H. Bradley Shaffer;Patrick Minx;Daniel E. Warren;Andrew M. Shedlock;Andrew M. Shedlock

  • The battle of the sexes.

    Blanche Capel

Frequent Co-Authors

Robin Lovell-Badge
Robin Lovell-Badge The Francis Crick Institute
Peter Koopman
Peter Koopman University of Queensland
Loren L. Looger
Loren L. Looger Howard Hughes Medical Institute
Joseph H. Nadeau
Joseph H. Nadeau Pacific Northwest Diabetes Research Institute
Keith L. Parker
Keith L. Parker The University of Texas Southwestern Medical Center
Eva M. Eicher
Eva M. Eicher The Jackson Laboratory
David M. Ornitz
David M. Ornitz Washington University in St. Louis
Uwe Ohler
Uwe Ohler Max Delbrück Center for Molecular Medicine
Andrew P. McMahon
Andrew P. McMahon University of Southern California

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